Jingya Zhou
Jingya Zhou
Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Collaborating Center for the WHO Family of International Classifications in China, Beijing, China
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Collaborating Center for the WHO Family of International Classifications in China, Beijing, China
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Meng Zhang
Meng Zhang
Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Collaborating Center for the WHO Family of International Classifications in China, Beijing, China
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Collaborating Center for the WHO Family of International Classifications in China, Beijing, China
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Lin Lu
Lin Lu
Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Key Laboratory of Endocrinology of National Health Commission of People’s Republic of China, Beijing, China
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Key Laboratory of Endocrinology of National Health Commission of People’s Republic of China, Beijing, China
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Xiaopeng Guo
Xiaopeng Guo
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Lu Gao
Lu Gao
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Weigang Yan
Weigang Yan
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Haiyu Pang
Haiyu Pang
Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Clinical Epidemiology Unit, International Epidemiology Network, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Yi Wang
Yi Wang
Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Collaborating Center for the WHO Family of International Classifications in China, Beijing, China
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Collaborating Center for the WHO Family of International Classifications in China, Beijing, China
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Bing Xing
Bing Xing
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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on the presence of clinical characteristics combined with at least one altered biochemical test, such as 24-h urinary free cortisol level, serum cortisol diurnal variation and the 1 mg overnight low-dose dexamethasone suppression test (LDDST). The
Natacha Driessens
Natacha Driessens
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Madhu Prasai
Madhu Prasai
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Orsalia Alexopoulou
Orsalia Alexopoulou
Department of Endocrinology, Cliniques Universitaires Saint Luc, Brussels, Belgium
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Christophe De Block
Christophe De Block
Department of Endocrinology-Diabetology-Metabolism, Universitair Ziekenhuis Antwerpen & University of Antwerp, Drie Eikenstraat, Edegem, Belgium
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Eva Van Caenegem
Eva Van Caenegem
Department of Endocrinology, Academisch Ziekenhuis Sint-Jan Brugge – Oostende AV, Ruddershove, Brugge, Belgium
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Guy T’Sjoen
Guy T’Sjoen
Department of Endocrinology, Ghent Universitary Hospital, C. Heymanslaan, Gent, Belgium
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Frank Nobels
Frank Nobels
Department of Endocrinology, Onze-Lieve Vrouw Ziekenhuis, Moorselbaan, Aalst, Belgium
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Christophe Ghys
Christophe Ghys
Department of Endocrinology, Universitair Ziekenhuis Brussel, Laarbeeklaan, Brussels, Belgium
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Laurent Vroonen
Laurent Vroonen
Department of Endocrinology, Cliniques Universitaires de Liège, Avenue de l’hôpital, Liège, Belgium
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Corinne Jonas
Corinne Jonas
Department of Endocrinology, CHU UCL Namur - Godinne, Avenue Docteur Gaston Thérasse, Yvoir, Belgium
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Bernard Corvilain
Bernard Corvilain
Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Department of Endocrinology, Route de Lennik, Brussels, Belgium
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Dominique Maiter
Dominique Maiter
Department of Endocrinology, Cliniques Universitaires Saint Luc, Brussels, Belgium
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criteria: (i) a simultaneous serum level cortisol below and a plasma ACTH 2-fold above reference ranges; (ii) a high plasma ACTH concentration with a failed cortisol response (<400 nmol/L) to 250 µg intravenous ACTH injection and/or (iii) chronic treatment
Dan Liang
Dan Liang
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Han Chen
Han Chen
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Li-Yong Zhong
Li-Yong Zhong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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–pituitary–adrenal axis (HPA): basal cortisol level <3 μg/dL indicated impaired HPA function while the basal cortisol level >15 μg/dL excluded it. If basal cortisol levels ranged from 3 to 15 μg/dL, the circadian rhythm of adrenocorticotropic hormone and cortisol (08
Sofia Maria Lider Burciulescu
Sofia Maria Lider Burciulescu
University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania
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National Institute of Endocrinology CI Parhon, Bucharest, Romania
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Monica Livia Gheorghiu
Monica Livia Gheorghiu
University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania
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National Institute of Endocrinology CI Parhon, Bucharest, Romania
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Andrei Muresan
Andrei Muresan
National Institute of Endocrinology CI Parhon, Bucharest, Romania
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Iuliana Gherlan
Iuliana Gherlan
University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania
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National Institute of Endocrinology CI Parhon, Bucharest, Romania
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Attila Patocs
Attila Patocs
Department of Laboratory Medicine and Molecular Genetics, Clinical Genetics and Endocrinology Laboratory, Semmelweis University National Institute of Oncology, Budapest, Hungary
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Corin Badiu
Corin Badiu
University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania
National Institute of Endocrinology CI Parhon, Bucharest, Romania
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National Institute of Endocrinology CI Parhon, Bucharest, Romania
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metastatic disease were CT scans and MRIs. The presence of AI was defined as low morning (08:00–09.00 h) cortisol level (<3 µg/dL) and insufficient cortisol response to a stimulation (Synachten) test at a maximum 1 month post surgery and the need of gluco
A Daniel Bird
A Daniel Bird
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
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Spencer Greatorex
Spencer Greatorex
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
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David Reser
David Reser
Department of Physiology, Monash University, Melbourne, Victoria, Australia
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Gareth G Lavery
Gareth G Lavery
Institute of Metabolism and Systems Research, 2nd Floor IBR Tower, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Timothy J Cole
Timothy J Cole
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
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and located on chromosome 1q32–41 in humans, is a bidirectional enzyme but normally acts as an oxidoreductase in vivo to drive formation of the active glucocorticoid cortisol. Located in the endoplasmic reticulum (ER) membrane, it requires NADPH
Aleksandra Gilis-Januszewska
Aleksandra Gilis-Januszewska
Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Łukasz Kluczyński
Łukasz Kluczyński
Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Alicja Hubalewska-Dydejczyk
Alicja Hubalewska-Dydejczyk
Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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hospitalized patients within 10 days of moderate and severe TBI (based on cortisol level lower than 11 µg/dL) ( 92 ). In another study, Bensalah et al. evaluated 200 patients during the first week after they sustained a TBI. He concluded that 2.8%, 21%, and
Karim Gariani
Karim Gariani
Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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causes of NAFLD. Hormone Gland of origin Example of disease Cortisol - Pituitary gland (ACTH) - Adrenal gland (cortisol) - Cushing’s disease - Cushing’s syndrome - Exogenous corticoid administration Thyroxine (T4
Kamran Iqbal
Kamran Iqbal
Shire, London, UK
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Kate Halsby
Kate Halsby
pH Associates, Marlow, UK
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Robert D Murray
Robert D Murray
Leeds Centre for Diabetes & Endocrinology, St James’s University Hospital, Leeds, UK
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Paul V Carroll
Paul V Carroll
Department of Endocrinology, Guy’s & St. Thomas’ NHS Foundation Trust, London, UK
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Robert Petermann
Robert Petermann
Shire, Vienna, Austria
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primary AI, a mineralocorticoid analogue (fludrocortisone), with the aim to replace the missing cortisol and aldosterone, respectively. Conventional immediate-release (IR) HC does not replicate the physiological circadian rhythm of endogenous cortisol
M Langeveld
M Langeveld
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
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C Y Tan
C Y Tan
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
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M R Soeters
M R Soeters
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
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S Virtue
S Virtue
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
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G K Ambler
G K Ambler
Cambridge Vascular Unit, Addenbrookes Hospital, Hills Road, Cambridge, UK
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L P E Watson
L P E Watson
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
NIHR/Wellcome Trust Clinical Research Facility, Addenbrookes Hospital, Cambridge, UK
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NIHR/Wellcome Trust Clinical Research Facility, Addenbrookes Hospital, Cambridge, UK
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P R Murgatroyd
P R Murgatroyd
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
NIHR/Wellcome Trust Clinical Research Facility, Addenbrookes Hospital, Cambridge, UK
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NIHR/Wellcome Trust Clinical Research Facility, Addenbrookes Hospital, Cambridge, UK
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V K Chatterjee
V K Chatterjee
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
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A Vidal-Puig
A Vidal-Puig
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, UK
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) were measured by time-resolved fluorescence immunoassay on an AutoDELFIA analyser (Perkin Elmer) using kits from Perkin Elmer. Cortisol level was measured by fluorescence immunoassay on the Siemens Centaur Autoanalyser. A minimum of two quality control
Manjunath Goroshi
Manjunath Goroshi
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
Jawaharlal Nehru Medical College, Belagavi, India
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Jawaharlal Nehru Medical College, Belagavi, India
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Swati S Jadhav
Swati S Jadhav
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Vijaya Sarathi
Vijaya Sarathi
Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India
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Anurag R Lila
Anurag R Lila
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Virendra A Patil
Virendra A Patil
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Ravikumar Shah
Ravikumar Shah
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Priya Hira
Priya Hira
Department of Radiology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Rajaram Sharma
Rajaram Sharma
Department of Radiology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Shettepppa Goroshi
Shettepppa Goroshi
Department of Radiology, Sri Nijalingappa Medical College Bagalkot, Navanagar, Karnataka, India
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Gwendolyn Fernandes
Gwendolyn Fernandes
Department of Pathology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Amey Rojekar
Amey Rojekar
Department of Pathology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Abhay Dalvi
Abhay Dalvi
Departments of General Surgery, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Ganesh Bakshi
Ganesh Bakshi
Department of Uro-Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
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Gagan Prakash
Gagan Prakash
Department of Uro-Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Tushar R Bandgar
Tushar R Bandgar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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considered as cortisol secreting, if overnight dexamethasone supressed serum cortisol was ≥1.8 µg/dL. Diagnosis of patients with AM was based on primary tumour histopathology and/or adrenal biopsy. CT protocol Imaging of the abdomen was performed on a
