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medicine reports were mainly taken into consideration. All patients underwent total-body PET/CT imaging with 68 Ga-SSA, MRI and fluorodeoxyglucose-PET/CT focused on bone lesions. Patients who presented reports of ambiguous interpretation were discarded due
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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with a median of 4 samples per patient (range: 2–12) in an average of 46 months of follow-up (6–71 months). CT was the most common imaging modality used ( n = 533), followed by DOTA-PET/CT ( n = 118) and MRI ( n = 71). During follow-up, 70 patients
Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, UK
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Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, UK
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confirmed by MRI post-HTS in-hospital or within 12 months follow-up. We also conducted further analyses to determine if there was a relationship between admission demographic (age and sex), anthropometric, and clinical variables with the risk of sodium
University of Alcalá, Madrid, Spain
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/mL) ( n = 83) 15.0 ± 10.97 20.2 ± 10.55 0.03 DHEAS (µg/dL) ( n = 48) 147.9 ± 294.23 126.4 ± 211.89 0.771 Maximum tumor size (mm) 24.4 ± 14.01 17.3 ± 6.84 <0.001 Unilateral lesion >2 cm in CT/MRI 37.3% ( n = 19) 17
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. Diabetes insipidus (DI) was seen in 46.6% of patients. MRI showed pituitary enlargement and thickened stalk in 81.8 and 90.6% of patients, respectively. The most common histopathological subtypes were lymphocytic ( n = 35) followed by IgG4 ( n = 9
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
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Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
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syndrome ( 82 ). Similarly, neurocognitive changes are described among males with 47,XYY syndrome ( 83 ). But while boys with Klinefelter syndrome have significantly smaller whole-brain volumes on MRI, males with 47,XYY seem to have normal brain volume ( 84
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MEN1 mutation, gastrointestinal echoendoscopy of the proband revealed multiple pancreatic neuroendocrine tumors (PNETs), <1 cm in diameter, while pituitary MRI was negative. In the brother (II-6), a right lesion close to the pharynx was identified
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spectroscopy (MRS) assesses PDFF directly through differences in water and lipid peaks on resonance frequency domains, whereas MRI indirectly estimates water and fat content through time-dependent oscillations in MR signals ( 41 ). Due to its direct nature of
Department of Endocrinology, St James’s Hospital, Dublin, Ireland
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Department of Endocrinology, University of Manchester, Manchester, UK
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Department of Paediatric Endocrinology & Diabetes, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
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Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK
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presumed CHD7 deletion Negative 14- gene screen Hem. ANOS1 c1756C>T [Q586X] Het. CHD7 c.8950C>T [p.L2984F] MRI Pituitary Normal Normal Normal Not tolerated Not tolerated Normal Normal Olfact. bulbs Absent
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reported elsewhere ( 28 ). One recent study with more advanced imaging (high-resolution magnetic resonance imaging (micro-MRI)) investigated the bone structure of ten young adults with hypogonadism and/or CO-GHD and reported that the ratio of apparent bone