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E -hexadecanal and phosphoethanolamine are also implicated in important cellular processes including cytoskeletal reorganization, apoptosis and oxidative phosphorylation ( 11 , 13 , 14 , 15 ). S1P lyase thus plays a critical role in the dynamicity
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of vesicles due to macrophage and VSMC apoptosis; these vesicles contain calcium and phosphate that could initiate nucleation centres for the formation of hydroxyapatite-based intimal AC ( 19 ). A further mechanism leading to calcification could
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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’s thyroiditis and that simvastatin treatment in vitro decreased the number of lymphocyte subtypes through apoptosis ( 32 ). In our study, we showed that simvastatin downregulates the proliferation of B and T lymphocytes in PBMCs activated by PHA and CD-40. CD
Tanaka Medical Clinic, Yoichi, Japan
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Institute for Clinical Research, NHO Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan
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Department of Cellular Physiology and Signal Transduction, Sapporo Medical University School of Medicine, Sapporo, Japan
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biomarker of glomerular damage ( 17 , 42 ). It has also been reported that exposure of kidney organ culture to TNFR1 or TNFR2 increases apoptosis mainly in tubules ( 43 ) and that individual knockout mouse models of TNFR1 or TNFR2 have a delay in the
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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GLP-1 exhibits cardio- and neuro-protection, together with inhibition of inflammation and apoptosis ( 6 ). An excessive inflammatory response can cause severe organ dysfunction ( 7 ). Increased blood glucose levels are frequently observed in septic
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Reference Center for Rare Disorders of Calcium and Phosphate Metabolism, Le Kremlin Bicêtre, France
Plateforme d’Expertise Paris Sud Maladies Rares and Filière OSCAR, Bicêtre Paris Sud, Le Kremlin Bicêtre, France
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Reference Center for Rare Disorders of Calcium and Phosphate Metabolism, Le Kremlin Bicêtre, France
Plateforme d’Expertise Paris Sud Maladies Rares and Filière OSCAR, Bicêtre Paris Sud, Le Kremlin Bicêtre, France
INSERM U1169, Hôpital Bicêtre, Le Kremlin Bicêtre, et Université Paris-Saclay, Le Kremlin Bicêtre, France
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APHP, Department of Pediatric Orthopedic Surgery, Necker Hospital, Paris, France
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because of the decreased apoptosis of the chondrocytes. Therefore, following surgery, open physes are prone to rickets, and hence bone deformities if the medical therapy is not sufficient. The findings of our study might have been limited by i- the
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malignancy in adrenal pheochromocytomas: clinical, histopathologic, and cell cycle/apoptosis gene expression analysis . Surgery 2008 6 759 – 768 . ( doi:10.1016/j.surg.2008.02.007 ) 15 Amar L Baudin E Burnichon N Peyrard S Silvera
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antitumor activities of 1,25D include the inhibition of cancer cell proliferation and angiogenesis, promotion of cell differentiation and apoptosis ( 4 , 5 , 6 , 7 , 8 ). The VDR is a receptor expressed by epithelial cells in both normal and
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress . American Journal of Physiology: Endocrinology and Metabolism 2010 299 . ( doi:10.1152/ajpendo.00238
Tulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USA
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Tulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USA
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biological aging. Telomeres are the protective caps at the ends of chromosomes that shorten with every cell division and serve as a molecular clock, with shorter TL reflecting older cellular age. TL is critical for cellular senescence and apoptosis and may