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Marek Niedziela Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland

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on Doppler examination (colour Doppler (CD) and power Doppler (PD); Fig. 1 ) in addition to hypoechogenicity of the gland. Vascular flow can be a valuable tool in the subsequent follow-up of hyperthyroid patients. Figure 1 (A, B, and C

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-21-0191
Volume/Issue:
Volume 10: Issue 11
Open access
Sandeep Kumar Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Anurag Ranjan Lila Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Saba Samad Memon Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Vijaya Sarathi Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India

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Virendra A Patil Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Santosh Menon Department of Pathology, Tata Memorial Hospital, Mumbai, India

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Neha Mittal Department of Pathology, Tata Memorial Hospital, Mumbai, India

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Gagan Prakash Department of Uro-oncology, Tata Memorial Hospital, Mumbai, India

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Gaurav Malhotra Department of Nuclear Medicine, Bhabha Atomic Research Centre, Mumbai, India

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Nalini S Shah Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Tushar R Bandgar Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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arrow). (D) Low-power photomicrograph of liver biopsy showing liver parenchyma (right side) being infiltrated by a cellular tumor (left side) (×40, hematoxylin & eosin (H and E)). (E) High-power microphotograph to show sheets of tumor cells with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0455
Volume/Issue:
Volume 10: Issue 11
Open access
Sakina H Bharmal School of Medicine, University of Auckland, Auckland, New Zealand

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Wandia Kimita School of Medicine, University of Auckland, Auckland, New Zealand

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Juyeon Ko School of Medicine, University of Auckland, Auckland, New Zealand

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Maxim S Petrov School of Medicine, University of Auckland, Auckland, New Zealand

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NOPAP with NAP. The area under the curve (AUC) was calculated to quantify the discriminatory power of pancreatic and gut hormones in predicting NOPAP ( 21 ). Cut-off thresholds, predictive values, and likelihood ratios were derived for each hormone ( 22

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0229
Volume/Issue:
Volume 10: Issue 7
Open access
Klaudia Zajkowska Endocrinology, Holycross Cancer Centre, Kielce, Poland

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Janusz Kopczyński Surgical Pathology, Holycross Cancer Centre, Kielce, Poland

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Stanisław Góźdź Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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Aldona Kowalska Endocrinology, Holycross Cancer Centre, Kielce, Poland
Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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, tumour necrosis, high mitotic activity (defined as three or more mitoses per ten high-power fields (×40)), papillae >1%, psammoma bodies or morphologic characteristics of other variants of PTC, such as tall cell, cribriform-morular and solid

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0566
Volume/Issue:
Volume 9: Issue 3
Open access
Petar Milovanovic Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Björn Busse Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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osteoarthritic human trabecular bone: implications for bone remodeling . Bone 2012 50 688 – 694 . ( https://doi.org/10.1016/j.bone.2011.11.021 ) 78 Power J Noble BS Loveridge N Bell KL Rushton N Reeve J . Osteocyte lacunar occupancy in the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0531
Volume/Issue:
Volume 9: Issue 4
Open access
Xue-Jiao Yang School of Public Health, Medical College of Soochow University, Suzhou, China

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Le-Yang Zhang Medical College of Soochow University, Suzhou, China

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Qing-Hua Ma The 3rd People’s Hospital of Xiangcheng District, Suzhou, China

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Hong-Peng Sun School of Public Health, Medical College of Soochow University, Suzhou, China

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Yong Xu School of Public Health, Medical College of Soochow University, Suzhou, China

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Xing Chen Department of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China

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Chen-Wei Pan School of Public Health, Medical College of Soochow University, Suzhou, China

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reduced risk of MetS in men and an elevated risk in women ( 36 ). Thus, one may hypothesize that gender-specific sex hormones may explain some of this phenomenon. Our study had a relatively large sample size so that the study power was sufficient to detect

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0209
Volume/Issue:
Volume 9: Issue 7
Open access
Jessica S Jarmasz Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

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Yan Jin Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

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Hana Vakili Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Peter A Cattini Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

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and reverse primers ((0.5 pM); 1 μL each) manufactured by Integrated DNA Technologies ( Table 1 ) and with Power SYBR® Green PCR Master Mix (10 μL; #4367659, Thermo Fisher Scientific). cDNA was denatured at 95ºC (5 min), followed by 40 cycles of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0354
Volume/Issue:
Volume 9: Issue 12
Open access
Maria Mizamtsidi Department of Endocrinology, Diabetes and Metabolism, Hellenic Red Cross Hospital, Athens, Greece

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Constantinos Nastos Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

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George Mastorakos Unit of Endocrinology, Diabetes and Metabolism, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Roberto Dina Department of Pathology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK

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Ioannis Vassiliou Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece

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Maria Gazouli Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Fausto Palazzo Department of Thyroid and Endocrine Surgery, Imperial College London, London, UK

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trabecular growth, remarkable mitotic activity (>1 mitosis per 10 high-power fields), tumor necrosis and incomplete invasion of the capsule. The significance of the remarkable mitotic activity is unclear. Their detection should prompt careful assessment

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0283
Volume/Issue:
Volume 7: Issue 2
Open access
J A Tamblyn Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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C Jenkinson Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK

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D P Larner Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK

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M Hewison Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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M D Kilby Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Birmingham Women’s Foundation Hospital, Edgbaston, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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resulted in statistical power of 0.588 at α  = 0.05. To reach power of >0.8 would have required n  = 41 per sample group. Nevertheless, our preliminary data indicate dysregulation of vitamin D metabolism may precede clinical onset of PET. This was evident

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0308
Volume/Issue:
Volume 7: Issue 1
Open access
Nathalia G B P Ferreira Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Joao L O Madeira Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Peter Gergics Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

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Renata Kertsz Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Juliana M Marques Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Nicholas S S Trigueiro Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Anna Flavia Figueredo Benedetti University of Michigan Medical School, Department of Human Genetics, Ann Arbor, Michigan, United States

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Bruna V Azevedo Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Bianca H V Fernandes Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
Universidade de São Paulo, Zebrafish Facility, São Paulo, São Paulo, Brazil

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Debora D Bissegatto Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Isabela P Biscotto Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Qing Fang Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

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Qianyi Ma Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

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Asye B Ozel Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

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Jun Li Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

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Sally A Camper Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

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Alexander A L Jorge Unidade de Endocrinologia Genética, Laboratório de Endocrinologia Celular e Molecular LIM25, Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

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Berenice B Mendonça Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Ivo J P Arnhold Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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Luciani R Carvalho Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil

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acid change from Val to Ile, a subtle alteration between two hydrophobic residues, which differ from each other by only one methyl group, completely changed the ligand selectivity of a protein. This discovery showcased the beauty and power of structural

Article Type:
Research Article
Collections:
Paediatric Endocrinology
DOI:
https://doi.org/10.1530/EC-22-0473
Volume/Issue:
Volume 12: Issue 8
Open access