Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
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Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
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UMR8638 CNRS, Pharmacy UFR, University of Paris Descartes, PRES sorbonne Paris Cité, Paris, France
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sample size, which limits the statistical power and the generalization of the results. Especially, data on etoposide clearance after mitotane discontinuation derived from a single patient. Further studies with larger cohorts are needed to confirm these
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limited. Controlled studies with sufficient statistical power to outline exercise programmes or physical activity guidelines tailored to NAFLD patients are lacking ( 64 ). Mechanisms underlying proposed benefits of exercise in NAFLD pertain to improvements
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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://doi.org/10.1016/0014-5793(84)80583-9 ) 18 Power DM Bunnett N Turner AJ Dimaline R . Degradation of endogenous heptadecapeptide gastrin by endopeptidase 24.11 in the pig . American Journal of Physiology 1987 253 G33 – G39 . ( https
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PCOS ( 11 , 26 ). For 90% power, significance level of 5% and adjusting for a possible 20% dropout rate, 20 subjects were enrolled in each group. Comparisons between both the groups from baseline were carried out using the paired t test for
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is that the number of patients included is relatively small, and the event rate is accordingly low, thereby limiting the power and reliability of the statistical analysis. It is difficult to draw a statistically significant conclusion if a subgroup
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Pharmacology, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
Copenhagen Center for Translational Research, Copenhagen University Hospital – Bispebjerg and Frederiksberg, University of Copenhagen, Copenhagen, Denmark
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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; thus, the multiple comparisons combined with the post hoc nature of the analyses limit the power of our statistical comparisons between groups. Furthermore, the correction for multiple testing increases the risk of type 2 errors. Data should be
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Parelsnoer Institute, Utrecht, The Netherlands
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can be regarded as a ‘large’ rare disease population. However large, this study population lacked power to detect meaningful differences. In addition, we considered the population as a possible source of selection bias, since our center is a national
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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catalyzed by enzymes, the methyl group of cytosine can be eliminated by passive processes, such as lack of function of DNMT1, allowing for the loss of methylation through cell divisions ( 28 , 29 ). Given the power of epigenetics to explain metabolic
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Morbid Obesity Centre, Department of Nutrition, Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Gynecology, Institute of Clinical Medicine, Department of Endocrinology, Vestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, Norway
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Morbid Obesity Centre, Department of Nutrition, Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Gynecology, Institute of Clinical Medicine, Department of Endocrinology, Vestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, Norway
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Morbid Obesity Centre, Department of Nutrition, Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Gynecology, Institute of Clinical Medicine, Department of Endocrinology, Vestfold Hospital Trust, PO Box 2168, 3103 Tønsberg, Norway
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attain a power of more than 80% ( α =0.05) to reveal this possible difference. Randomization, allocation and implementation Participants were randomized in blocks of six (three participants to each group). Sealed pre-numbered containers were opened by the
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actual participant numbers, the retrospective power estimate for detecting a difference in the A-V glucose uptake into muscle was 84%, based on a treatment s.d . of 58 and a measured treatment effect of 111 mmol/l per 100 ml tissue. For the MRI measures