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patient regarding the long-term effects of the diagnosis and management • Is able to assess the effectiveness of treatment • Has awareness and knowledge of local GH and IGF1 reference ranges • Initiates medical therapies including self
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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region around the insulin gene may have possible autocrine stimulatory growth effects in phaeochromocytomas. They overexpress IGF-2 and its receptor ( 20 ) and the IGF-1 receptor ( 36 ), and the overexpression is most pronounced in malignant tumours ( 37
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Clinical features, biochemical evaluation, treatment and follow-up of patients. Case No. Age at initial presentation (years)/sex Presenting feature FT4 (ng/dL) (0.8–1.8)/TSH (µIU/mL) (0.4–4.0) IGF1 (ng/mL) (age specific normal range) 8
Department of Endocrinology, The People’s Hospital of Daxing District, Beijing, China
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fat is a rather late phenomenon . European Journal of Endocrinology 2015 173 149 – 153 . ( https://doi.org/10.1530/EJE-14-1140 ) 26142100 10.1530/EJE-14-1140 12 Smith TJ Hegedus L Douglas RS . Role of insulin-like growth factor-1 (IGF-1
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metabolism. This hormone is secreted by the pituitary gland and acts directly on target cells by signaling through its membrane-associated receptor. GH also promotes insulin-like growth factor type 1 (IGF1) synthesis, principally in the liver, which then
Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
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Division of Auxology and Metabolic Diseases, IRCSS Istituto Auxologico Italiano, Piancavallo (VB), Italy
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Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
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Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
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-like growth factor 1 (IGF1) = 201 ng/mL, n.v. 141–669; thyroid-stimulating hormone (TSH) = 1.85 mU/L, n.v. 0.27–4.5; free T4 = 15.9 pmol/L, n.v. 11.5–24.5; prolactin (PRLb) = 6.1 ng/mL; n.v. 2.5–17) with prepubertal response of LH and FSH to GnRH test, low
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of typical clinical features, an elevated age- and gender-matched serum insulin-like growth factor-1 (IGF-1) and inability to suppress GH to <0.4 µg/L following a 75 g oral glucose load. ACTH adenomas were diagnosed based on clinical and biochemical
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IGF1 intervention could upregulate G protein-coupled estrogen receptor (GPER) expression through epigenetic modulation to increase the sensitivity of endometrial cells to estrogen ( 12 , 13 ). Collectively, insulin resistance, chronic inflammation and
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute of Medical Research, University of Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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insulin tolerance test (ITT) or the glucagon stimulation test, where the ITT was contraindicated, was used to assess the integrity of the growth hormone (GH) and hypothalamic–pituitary–adrenal axes. Insulin-like growth factor 1 (IGF1) and thyroid function
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109119 . ( https://doi.org/10.1016/j.diabres.2021.109119 ) 2 Dong R Yu JL Yu FX Yang S Qian Q & Zha Y . IGF-1/IGF-1R blockade ameliorates diabetic kidney disease through normalizing Snail 1 expression in a mouse model . American Journal