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Lian Hollander-Cohen Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, Hebrew University of Jerusalem, Rehovot, Israel

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Benjamin Böhm Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, Hebrew University of Jerusalem, Rehovot, Israel

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Krist Hausken Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, Hebrew University of Jerusalem, Rehovot, Israel

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Berta Levavi-Sivan Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, Hebrew University of Jerusalem, Rehovot, Israel

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when injected to mature female carps in vivo ( 23 ). Isolation of carp ovarian follicles and steroid ELISA Ovaries were collected immediately upon killing the fish and incubated as described previously ( 19 ). After rinsing, the medium was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0389
Volume/Issue:
Volume 8: Issue 11
Open access
Fernando Aprile-Garcia Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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María Antunica-Noguerol Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Maia Ludmila Budziñski Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Ana C Liberman Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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Eduardo Arzt Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina

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adaptive responses to stressful circumstances. GCs belong to the steroid hormone family, a group of small lipophilic compounds derived from cholesterol, its common precursor. Steroid hormones are generally grouped according to the receptors they bind and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-13-0079
Volume/Issue:
Volume 3: Issue 1
Open access
Alessandro Ciresi Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Stefano Radellini Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Valentina Guarnotta Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Maria Grazia Mineo Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Carla Giordano Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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estrogen receptors are expressed in the pituitary, regulating GH gene expression and reducing somatostatin receptor expression, leading to enhanced GH secretion ( 6 ). Lastly, the role of gender and sex steroids in modulating the clearance of GH must be

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0135
Volume/Issue:
Volume 7: Issue 7
Open access
Yael Sofer Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Nava Nevo Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

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Michal Vechoropoulos Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Gabi Shefer Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Etty Osher Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Nathan Landis Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Karen Tordjman
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Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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Naftali Stern Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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steroids, and it has been traditionally postulated that the role of SHBG is limited to the transport of sex steroids into the target cells ( 2 , 3 ). However, it has also been reported that SHBG interacts with a trans-membrane receptor that activates

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0240
Volume/Issue:
Volume 7: Issue 1
Open access
Martin Wiegand MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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David J Halsall Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Sarah L Cowan Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Kevin Taylor Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Robert J B Goudie MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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Jacobus Preller Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Mark Gurnell Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Wellcome–MRC Institute of Metabolic Science, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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sample was reconstituted in 350 μL of steroid-free serum (DRG Instruments GmbH, Marburg, Germany). Extraction efficiency was calculated using a cohort of 15 anonymised COVID-19 negative control subjects (data not shown). Extraction efficiency was shown to

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-22-0190
Volume/Issue:
Volume 11: Issue 11
Open access
Emma Jernberg Department of Medical biosciences, Umeå University, Umeå, Sweden

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Anders Bergh Department of Medical biosciences, Umeå University, Umeå, Sweden

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Pernilla Wikström Department of Medical biosciences, Umeå University, Umeå, Sweden

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point mutations generally affect the c-terminal LBD, while about one-third occur in the transactivating NTD ( 29 , 30 ) resulting in broaden ligand specificity and AR activation by weak adrenal androgens and other steroid hormones, including DHEA

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0118
Volume/Issue:
Volume 6: Issue 8
Open access
Barbara J Boucher Blizard Institute, Barts & The London school of Medicine & Dentistry, Queen Mary University of London, London, UK

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O & Hocher B . Impact of vitamin D on pregnancy-related disorders and on offspring outcome . Journal of Steroid Biochemistry and Molecular Biology 2018 180 51 – 64 . ( https://doi.org/10.1016/j.jsbmb.2017.11.008 ) 8 Spaight C , Gross

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0274
Volume/Issue:
Volume 9: Issue 9
Open access
Ruth Percik Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel

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Sherwin Criseno Department of Endocrinology, University Hospital Birmingham, Birmingham, UK

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Safwaan Adam Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK

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Kate Young Royal Marsden Hospital, London, UK

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Daniel L Morganstein Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK

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steroids have been used, then standard approaches to weaning should be followed, but if after a prolonged period there has been no recovery of endogenous cortisol production, then the possibility of co-existent ACTH deficiency should be considered. Hence

Article Type:
Review Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0513
Volume/Issue:
Volume 12: Issue 5
Open access
Mirjana Kocova Department of Endocrinology and Genetics, Medical Faculty, University Pediatric Clinic, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

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Vesna Janevska Institute of Pathology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

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Violeta Anastasovska Genetic Laboratory, Medical Faculty, University Pediatric Clinic, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

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of patients with a homozygous p.I172N mutation causing the SV form of the disease with enzyme activity up to 2% ( 6 , 20 , 14 , 17 ). However, isolated cases with 11-hydroxylase and 3b-hydroxyl steroid dehydrogenase gene mutations as well as rare

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0097
Volume/Issue:
Volume 7: Issue 4
Open access
Siphiwe N Dlamini SAMRC/Wits Developmental Pathways for Health Research Unit (DPHRU), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Non-communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa

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Zané Lombard Division of Human Genetics, National Health Laboratory Service, and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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Lisa K Micklesfield SAMRC/Wits Developmental Pathways for Health Research Unit (DPHRU), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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Nigel Crowther Department of Chemical Pathology, National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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Shane A Norris SAMRC/Wits Developmental Pathways for Health Research Unit (DPHRU), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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Tracy Snyman Department of Chemical Pathology, National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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Andrew A Crawford Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK

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Brian R Walker BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
Institute of Genetic Medicine to Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK

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Julia H Goedecke SAMRC/Wits Developmental Pathways for Health Research Unit (DPHRU), School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Non-communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa

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medications for elevated blood pressure and diabetes were also considered as relevant indicators of the presence of elevated blood pressure and fasting blood glucose concentrations, respectively. Steroid extraction and glucocorticoid measurements

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0195
Volume/Issue:
Volume 10: Issue 8
Open access