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Katherine U Gaynor Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Irina V Grigorieva Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Samantha M Mirczuk Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Sian E Piret Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Kreepa G Kooblall Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Mark Stevenson Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Karine Rizzoti The Francis Crick Institute, London, UK

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Michael R Bowl Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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M Andrew Nesbit Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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Paul T Christie Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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William D Fraser Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK

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Tertius Hough MRC Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, Oxfordshire, UK

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Michael P Whyte Washington University in St Louis School of Medicine, Center for Metabolic Bone Disease and Molecular Research, St Louis, Missouri, USA

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Robin Lovell-Badge The Francis Crick Institute, London, UK

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Rajesh V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK

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from Illinois (IL), USA ( 11 ). Both families from MO and the family from IL had interstitial deletion-insertions involving deletion of a non-coding region on chromosome Xq27.1 between sex-determining region Y (SRY)-box 3 ( SOX3 ) and adenosine

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Kusum Lata Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Pinaki Dutta Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Subbiah Sridhar Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Minakshi Rohilla Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Anand Srinivasan Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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G R V Prashad Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Viral N Shah Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Anil Bhansali Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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.0–2.5%, intra-assay CV 1.0–2.5%); and anti-TPO, RR: <34 IU/ml. All patients with TPOAb + were treated with 25 μg l -T 4 and titrated according to TSH at the time of recruitment into the study. The patients who had subclinical hypothyroidism were treated as

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Zeming Liu Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Di Hu Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Yihui Huang Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Sichao Chen Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Wen Zeng Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China

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Ling Zhou Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Wei Zhou Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Min Wang Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Haifeng Feng Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Wei Wei Department of Pediatrics, St John Hospital and Medical Center, Detroit, Michigan, USA

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Chao Zhang Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Danyang Chen Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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Liang Guo Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

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from population-based cancer registries covering approximately 34.6% of the US population. This study was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University. We examined the data from 1376 cases of pediatric thyroid cancer

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Stavroula A Paschou Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Nektaria Papadopoulou-Marketou Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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George P Chrousos Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Christina Kanaka-Gantenbein Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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-DR3, DQB1*0201 (also referred as DR3-DQ2) or HLA-DR4, DQB1*0302 (also referred as DR4-DQ8) haplotypes compared to 40% of the healthy individuals. In addition, about 30% of the patients have both haplotypes (DR3/4 heterozygotes) ( 9 , 10 ). On the

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Kate E Lines Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Mahsa Javid Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Anita A C Reed Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Gerard V Walls Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Mark Stevenson Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Michelle Simon MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK

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Kreepa G Kooblall Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Sian E Piret Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Paul T Christie Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Paul J Newey Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Ann-Marie Mallon MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK

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Rajesh V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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oncogene homologue ( Kras )); wnt signalling (wingless-type MMTV integration site family member 2B ( Wnt2b )); interleukin signalling (Interleukin-3 receptor subunit alpha ( Il3ra )) and apoptosis signalling (TNF receptor superfamily member 10a ( Tnfrsf10a

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Darling M Rojas-Canales The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Michaela Waibel Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
The University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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Aurelien Forget Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia

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Daniella Penko The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Jodie Nitschke The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Fran J Harding Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia

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Bahman Delalat Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia

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Anton Blencowe Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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Thomas Loudovaris Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia

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Shane T Grey The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Helen E Thomas Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
The University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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Thomas W H Kay Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
The University of Melbourne, Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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Chris J Drogemuller The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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Nicolas H Voelcker Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

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Patrick T Coates The Centre for Clinical and Experimental Transplantation (CCET) The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia, Australia
Department of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, South Australia, Australia

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isolating centers worldwide and an accepted reference shipping method ( 22 , 33 , 34 ). The PDMS devices were prepared for transport by inserting a permeable filter mesh to cover the islet-containing microwell surface, then filling the device with complete

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Tatsuya Kondo Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan

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Nobukazu Miyakawa Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Sayaka Kitano Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan

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Takuro Watanabe Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Rieko Goto Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Mary Ann Suico Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Miki Sato Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Yuki Takaki Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Masaji Sakaguchi Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Motoyuki Igata Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Chuo-Ward, Kumamoto, Japan

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Junji Kawashima Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Hiroyuki Motoshima Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Takeshi Matsumura Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Hirofumi Kai Department of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Eiichi Araki Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Chuo-Ward, Kumamoto, Japan

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Metabolic syndrome Type 2 diabetes P -value Number of participants 10 40 100 Age (years) 34.0 ± 4.7 52.7 ± 6.8 ‡ 62.7 ± 11.6 ||,** 0.002 Male (%) 100 100 82 Diabetes history (years) N.A. N.A. 8

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Lisa Arnetz Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Neda Rajamand Ekberg Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Kerstin Brismar Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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Michael Alvarsson Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes
Departments of Endocrinology, Molecular Medicine and Surgery, Metabolism and Diabetes

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<0.001 for ACTH, P =0.012 for NaCl in healthy subjects). Serum cortisol levels decreased after NaCl injection (for T2D patients from 409±34 nmol/l (basal) to 260±37 nmol/l after 90 min; P =0.008 for basal vs 90 min). For healthy subjects, cortisol

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Kristin Ottarsdottir Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Anna G Nilsson Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden

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Margareta Hellgren Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Ulf Lindblad Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Bledar Daka Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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hypogonadism ( 11 ). Furthermore, there is evidence that testosterone could increase insulin sensitivity by decreasing the levels of cytokines (TNFa and IL6), which are believed to increase insulin resistance ( 12 , 13 ). Therefore, it has been suggested that

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Stefano Mangiola Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Ryan Stuchbery Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia

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Patrick McCoy Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Ken Chow Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Natalie Kurganovs Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Ontario Institute for Cancer Research, Toronto, Canada
Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

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Michael Kerger Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Anthony Papenfuss Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia
Department of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia

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Christopher M Hovens Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Niall M Corcoran Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia

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analysis is performed integrating such inference with the treatment status. The first approach applied the algorithm Cibersort ( 33 ), for the inference of tissue composition, in combination with DirichletReg ( 34 ), for the regression of the proportional

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