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from Illinois (IL), USA ( 11 ). Both families from MO and the family from IL had interstitial deletion-insertions involving deletion of a non-coding region on chromosome Xq27.1 between sex-determining region Y (SRY)-box 3 ( SOX3 ) and adenosine
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.0–2.5%, intra-assay CV 1.0–2.5%); and anti-TPO, RR: <34 IU/ml. All patients with TPOAb + were treated with 25 μg l -T 4 and titrated according to TSH at the time of recruitment into the study. The patients who had subclinical hypothyroidism were treated as
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from population-based cancer registries covering approximately 34.6% of the US population. This study was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University. We examined the data from 1376 cases of pediatric thyroid cancer
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-DR3, DQB1*0201 (also referred as DR3-DQ2) or HLA-DR4, DQB1*0302 (also referred as DR4-DQ8) haplotypes compared to 40% of the healthy individuals. In addition, about 30% of the patients have both haplotypes (DR3/4 heterozygotes) ( 9 , 10 ). On the
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oncogene homologue ( Kras )); wnt signalling (wingless-type MMTV integration site family member 2B ( Wnt2b )); interleukin signalling (Interleukin-3 receptor subunit alpha ( Il3ra )) and apoptosis signalling (TNF receptor superfamily member 10a ( Tnfrsf10a
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St Vincent’s Institute of Medical Research, Fitzroy, Victoria, Australia
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isolating centers worldwide and an accepted reference shipping method ( 22 , 33 , 34 ). The PDMS devices were prepared for transport by inserting a permeable filter mesh to cover the islet-containing microwell surface, then filling the device with complete
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Metabolic syndrome Type 2 diabetes P -value Number of participants 10 40 100 Age (years) 34.0 ± 4.7 52.7 ± 6.8 ‡ 62.7 ± 11.6 ||,** 0.002 Male (%) 100 100 82 Diabetes history (years) N.A. N.A. 8
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<0.001 for ACTH, P =0.012 for NaCl in healthy subjects). Serum cortisol levels decreased after NaCl injection (for T2D patients from 409±34 nmol/l (basal) to 260±37 nmol/l after 90 min; P =0.008 for basal vs 90 min). For healthy subjects, cortisol
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hypogonadism ( 11 ). Furthermore, there is evidence that testosterone could increase insulin sensitivity by decreasing the levels of cytokines (TNFa and IL6), which are believed to increase insulin resistance ( 12 , 13 ). Therefore, it has been suggested that
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analysis is performed integrating such inference with the treatment status. The first approach applied the algorithm Cibersort ( 33 ), for the inference of tissue composition, in combination with DirichletReg ( 34 ), for the regression of the proportional