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Rongpeng Gong Medical College of Qinghai University, Xining, People’s Republic of China

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Yuanyuan Liu Medical College of Qinghai University, Xining, People’s Republic of China

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Gang Luo Medical College of Qinghai University, Xining, People’s Republic of China

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Jiahui Yin College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China

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Zuomiao Xiao Department of Clinical Laboratory, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, China

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Tianyang Hu Precision Medicine Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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imputation method was used to impute missing variables in order to maximize statistical power and minimize bias. In addition, to determine whether the generated complete data differed significantly from the original data, a sensitivity analysis was performed

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0066
Volume/Issue:
Volume 11: Issue 7
Open access
Simon Chang Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Internal Medicine, Lillebaelt Hospital, Kolding, Denmark

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Arkadiusz J Goszczak NanoSYD, The Mads Clausen Institute, University of Southern Denmark, Sønderborg, Denmark

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Anne Skakkebæk Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark

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Jens Fedder Centre of Andrology and Fertility Clinic, Odense University Hospital, Odense, Denmark

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Anders Bojesen Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark

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M Vakur Bor Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark

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Moniek P M de Maat Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark
Department of Haematology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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Claus H Gravholt Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Anna-Marie B Münster Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark

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positive association between fibrin clot lysis and testosterone levels. Subgroup analysis in KS or controls alone fell short of being statistically significant, potentially due to power issues. We have previously published epidemiological data supporting

Article Type:
Research Article
Collections:
Cardiovascular
DOI:
https://doi.org/10.1530/EC-21-0490
Volume/Issue:
Volume 11: Issue 5
Open access
Orwa Dandash Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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James Allebone Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Adam Mirabelli Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Nicholas Russell Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Mathis Grossmann Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Andrea Gogos Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia

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Richard A Kanaan Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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showed that 28 days of treatment with 1mg of transdermal E2 patches in testosterone deplete men with prostate cancer was sufficient to restore serum E2 concentrations into the reference range reported for healthy men ( 33 ). Power analysis Based

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-23-0409
Volume/Issue:
Volume 13: Issue 3
Open access
Régis Coutant Department of Pediatric Endocrinology and Diabetology, Reference Center for Rare Pituiatry Diseases, University Hospital of Angers, Angers, France

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Maithé Tauber Reference Center for the Prader-Willi syndrome and other rare obesities with feeding disorders (PRADORT), Children Hospital, CHU Toulouse, Toulouse, France
Pediatric team of the Clinical Investigation Center 9302/INSERM, Hospital of Children, Toulouse, France
Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), INSERM UMR1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France

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Béatrice Demaret GRANDIR - French Growth Disorders Association, Asnières-sur-Seine, France

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Robin Henocque Pfizer France, Paris France

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Yves Brault Pfizer France, Paris France

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François Montestruc eXYSTAT, Malakoff, France

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Olivier Chassany Health Economics Clinical Trial Unit (URC-ECO), Hospital of Hotel-Dieu, AP-HP, Paris, France
Patient-Reported Outcomes Unit (PROQOL), UMR 1123, University Paris Cité, INSERM, Paris, France

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Michel Polak Hôpital Universitaire Necker Enfants Malades, Pediatric Endocrinology, Gynecology and Diabetology, Imagine Institute, INSERM U1163, Cochin Institute, INSERM U1016, Centre de référence des pathologies endocriniennes rares de la croissance et du développement, Université de Paris Cité, Paris, France

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the QOLITHOR Study Group
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the QOLITHOR Study Group

ρ = 0 ( α  = 0.05 two-sided) for the level of the overall life interference total score according to the GH treatment duration (analyzed as a continuous variable) had 90% power to detect a correlation coefficient ρ of at least 0.25. The

Article Type:
Research Article
Collections:
Paediatric Endocrinology
DOI:
https://doi.org/10.1530/EC-22-0464
Volume/Issue:
Volume 12: Issue 4
Open access
Suvanjaa Sivalingam Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Marianne Thvilum Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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Thomas Heiberg Brix Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
Department of Clinical Research, University of Southern Denmark, Odense M, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark
Department of Regional Health Research, University of Southern Denmark, Odense M, Denmark

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impact of month of birth for the development of GD has only received little attention ( 18 , 19 ). Due to low power, the findings have been inconclusive. In contrast to GD, it has never been investigated whether TNG is influenced by seasonality in month

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0185
Volume/Issue:
Volume 7: Issue 10
Open access
Myrtille Fouché Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Yves Bouffard Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Mary-Charlotte Le Goff Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Johanne Prothet Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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François Malavieille Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Pierre Sagnard Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Françoise Christin Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Davy Hayi-Slayman Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Arnaud Pasquer Department of Visceral Surgery, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Gilles Poncet Department of Visceral Surgery, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Thomas Walter Department of Hepatogastroenterology and Oncology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Thomas Rimmelé Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France
EA 7426 Hospices Civils de Lyon-University Claude Bernard Lyon 1-Biomérieux ‘Pathophysiology of Injury-Induced Immunosuppression’ Pi3, Lyon, France

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postoperative complications. Thus, the impact of ioCS on outcomes, as Condron and Massimino et al. reported was not feasible ( 19 , 21 ). In addition, a lack of power due to the relatively small sample size did not facilitate the identification of ioCS risk

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0324
Volume/Issue:
Volume 7: Issue 12
Open access
Nassim Ghaffari-Tabrizi-Wizsy Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Christina Angelika Passegger Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Laura Nebel Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Fabian Krismer Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Gudrun Herzer-Schneidhofer Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Gert Schwach Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Roswitha Pfragner Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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least prior to work with mouse system ( Fig. 5 ). Therefore, CAM assay could serve as a preclinical tool for seeking drugs against MTC and might help to increase the power and speed of the development of new drugs. Figure 5 Chick before the mouse

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0431
Volume/Issue:
Volume 8: Issue 5
Open access
B C M Hermans Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands

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J L Derks Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands

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H J M Groen Department of Pulmonary Diseases, University of Groningen and University Medical Centre, Groningen, The Netherlands

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J A Stigt Department of Pulmonary Diseases, Isala Hospital, Zwolle, The Netherlands

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R J van Suylen Pathology-DNA, Jeroen Bosch Hospital, ‘s Hertogenbosch, The Netherlands

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L M Hillen Department of Pathology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands

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E C van den Broek PALGA Foundation, Utrecht, The Netherlands

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E J M Speel Department of Pathology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands

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A-M C Dingemans Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands

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tumors with a low Ki-67 PI of 15% were diagnosed as LCNEC because of the presence of necrosis and a mitotic index of 14 and >30 per 10 high power fields, respectively (patients F and H). The patients had a median OS of 12 months (95% confidence Interval

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0372
Volume/Issue:
Volume 8: Issue 12
Open access
Keina Nishio Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Akiko Tanabe Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Risa Maruoka Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Kiyoko Nakamura Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Masaaki Takai Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Tatsuharu Sekijima Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Satoshi Tunetoh Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Yoshito Terai Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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Masahide Ohmichi Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-city, Osaka 569-8686, Japan

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patients. The average serum BAP was not significantly elevated in the OC and EC groups; however, the power of this study to detect a significant difference was limited. These differences may be significant if a larger number of subjects were analyzed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0043
Volume/Issue:
Volume 2: Issue 1
Open access
Mabel E Bohórquez Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia

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Ana P Estrada Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia

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Jacob Stultz Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Ruta Sahasrabudhe Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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John Williamson Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Paul Lott Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Carlos S Duque Hospital Pablo Tobón Uribe, Medellín, Colombia

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Jorge Donado Hospital Pablo Tobón Uribe, Medellín, Colombia

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Gilbert Mateus Hospital Federico Lleras Acosta, Ibagué, Colombia

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Fernando Bolaños Hospital Hernando Moncaleano Perdomo, Neiva, Colombia

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Alejandro Vélez Hospital Pablo Tobón Uribe, Medellín, Colombia

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Magdalena Echeverry Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia

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Luis G Carvajal-Carmona Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Fundación de Genética y Genómica, Medellín, Colombia

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and Chinese populations, we failed to replicate association between HABP2 G534E and TC risk in Hispanic population as well. We, however, acknowledge that our study may have limited power to detect the low-penetrance effect of a variant that is

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0017
Volume/Issue:
Volume 5: Issue 3
Open access