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, develops through a complex interaction of genetic and environmental risk factors which result in autoimmune destruction of the specific organs involving humoral and cellular immune responses ( 1 , 2 , 4 , 8 , 9 ). Many studies have showed the prevalence
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development of CRC involves alterations not only in tumor tissues but also other organ systems, including the immune system ( 13 , 14 ). Leukocytes serve as a major component of immunology and have the advantages of easy access and detection. Analyses have
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Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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, the role of the MRP14 homodimer is not clear in Hashimoto’s thyroiditis (HT). HT is characterised by infiltration of thyroid-specific T lymphocytes and other immune cells, thyroid enlargement and fibrosis and progressive destruction of thyrocytes
Department of Research and Development, Region Kronoberg, Växjö, Sweden
Region Kronoberg, Primary Care, Växjö, Sweden
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Department of Research and Development, Region Kronoberg, Växjö, Sweden
Department of Internal Medicine, Endocrinology and Diabetes, Central Hospital, Växjö, Sweden
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activation of the innate immune system causing systemic inflammation ( 2 , 3 , 5 , 6 , 7 ). We have previously shown in these patients with T1D that depression was associated with inadequate glycaemic control ( 8 ), and with high midnight salivary
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effect was enhanced when MAOI was used in combination with immune checkpoint anti-PD-1 treatment ( 24 ). Also, MAO-A promotes tumor-associated macrophages’ immunosuppressive functions via upregulation of oxidative stress which could be regulated by the
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monocytes, have been reported as prognostic factors in various cancers ( 28 , 29 ). Lymphocytes play an important role in host tumor immunity, for example, by inhibiting cytotoxic cell death and tumor cell proliferation and migration ( 30 , 31 , 32 ). A
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Center for Healthy Aging, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany
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- and gender-dependent diseases and health protection. Multiple interconnections with vitamin D have been revealed for auto-immune diseases. Some of these topics are expected to be the subject of further articles in this special series. Vitamin D
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as a signaling molecule in immunity and inflammation, activated by various stress signals, including viral infections. Upon cytoplasmic DNA binding, cyclic GMP-AMP synthase (cGAS) facilitates the generation of cyclic guanosine monophosphate
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the aim of the study. The mechanism of GD in patients with neutropenia is not completely clear. The current data cannot determine the relationship between the RAIU and the functional status of immune cells. Granulocyte colony-stimulating factor (G
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( 15 ). For autoimmune hepatitis, the primary therapeutic approach is immunosuppressive therapy with glucocorticoids to quell the immune response causing liver inflammation. Monitoring of liver function, viral load, and disease progression is key to