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.001). Evidence of an MI effect was also identified for the HOMA index which decreased with treatment in the MI group compared to controls (SMD = −0.585, 95% CI: −1.145 to −0.025, P = 0.041) ( Fig. 3 ). Again, high heterogeneity across studies was found ( Q
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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% CI: 0.90–0.99, Fig. 2A ) and without evidence of heterogeneity (I 2 of 0%, P -value = 0.49). Figure 2 Forest plots of serum testosterone and all-cause mortality. (A) Association of continuous serum testosterone with all-cause mortality. (B
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women has been reported in some populations ( 18 , 19 , 20 ); however, more recent meta-analyses showed that there is no overall effect on FBC risk ( 21 , 22 , 23 ). In line with these meta-analysis studies, our study provides no evidence that CYP1B
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Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
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services. This is another area of unmet needs, and clinicians need resources and services to signpost patients to evidence-based information to standardise advice and information dissemination. Although we did not find a significant difference across
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channels, which opens calcium stores (26, 27) . All this evidence indicates a complex interplay between IGF1 and calcium homeostasis as well as its regulators. However, no study to date has investigated the association between circulating levels of markers
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accumulating evidence suggests that sex hormones are relevant to its development ( 3 ). There is an observational phenomenon and clinical evidence suggesting that men tend to have a much higher risk of CRC than women of the same age ( 4 ). As one of the most
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
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Department of Pathology, University of California, San Francisco, California, USA
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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pelvic sidewall, with direct invasion into the fundus of the uterus and fistulization into the endometrial canal ( Fig. 2 ). A staging PET/CT demonstrated no evidence of metastatic disease; however, peritoneal carcinomatosis was discovered during a
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
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–4 times less than testosterone) ( 2 , 13 , 15 , 16 ). Recently, evidence is found for differential binding of androgens and estrogens to SHBG ( 16 ) and dynamic regulation of the homodimeric SHBG-binding sites ( 2 , 17 , 18 ). In their review Goldman
Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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University of Chicago, Chicago, Illinois, USA
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metabolic parameters, including weight gain, adiposity and glucose tolerance. Evidence that diet composition modulates the metabolic consequences of pesticide residues suggests that Environmental Protection Agency tolerance limits may need modification based
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-line therapies worldwide ( 24 , 67 ). A study ( 70 ) ( n = 29 patients with T2DM) with gliclazide reported no change in SUA levels. Similar results have been reported in another study ( 71 ). At present, the mechanism is unclear, and there is no evidence