Arno Téblick
Arno Téblick
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Lies Langouche
Lies Langouche
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Greet Van den Berghe
Greet Van den Berghe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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reduction in cellular oxygen and/or energy delivery, and insufficiently activated defense mechanisms induce mitochondrial dysfunction and consequently, a downregulation of cellular metabolism ( 7 , 8 ). Although survival from previously lethal conditions is
Marie Oertel
Marie Oertel
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
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Christian G Ziegler
Christian G Ziegler
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
Department of Internal Medicine III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
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Department of Internal Medicine III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
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Michael Kohlhaas
Michael Kohlhaas
Comprehensive Heart Failure Center, Würzburg, Germany
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Alexander Nickel
Alexander Nickel
Comprehensive Heart Failure Center, Würzburg, Germany
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Simon Kloock
Simon Kloock
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
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Christoph Maack
Christoph Maack
Comprehensive Heart Failure Center, Würzburg, Germany
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Vasco Sequeira
Vasco Sequeira
Comprehensive Heart Failure Center, Würzburg, Germany
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
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Ulrich Dischinger
Ulrich Dischinger
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, Würzburg, Germany
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Comprehensive Heart Failure Center, Würzburg, Germany
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are limited. In contrast, bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is associated with a pronounced reduction in body weight, due to a reduction of energy intake of up to 50% ( 8 , 9 , 10 , 11 , 12 , 13 , 14 ). Most likely
Stavroula A Paschou
Stavroula A Paschou
Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece
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Eleni Palioura
Eleni Palioura
Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece
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Dimitrios Ioannidis
Dimitrios Ioannidis
Department of Endocrinology and Diabetes, Sismanoglio-Amalia Fleming Hospital, Athens, Greece
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Panagiotis Anagnostis
Panagiotis Anagnostis
Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Argyro Panagiotakou
Argyro Panagiotakou
Department of Endocrinology and Diabetes, Sismanoglio-Amalia Fleming Hospital, Athens, Greece
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Vasiliki Loi
Vasiliki Loi
Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece
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Georgios Karageorgos
Georgios Karageorgos
Department of Endocrinology and Diabetes, Sismanoglio-Amalia Fleming Hospital, Athens, Greece
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Dimitrios G Goulis
Dimitrios G Goulis
Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Andromachi Vryonidou
Andromachi Vryonidou
Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece
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SA Mantzoros CS. Leptin and hormones: energy homeostasis . Endocrinology Metabolism Clinics of North America 2016 45 633 – 645 . ( doi:10.1016/j.ecl.2016.04.012 ) 10.1016/j.ecl.2016.04.012 29 Sulcová J Hill M Hampl R Stárka
Zheng Chen
Zheng Chen
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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Haixia Zeng
Haixia Zeng
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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Qiulan Huang
Qiulan Huang
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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Cuiping Lin
Cuiping Lin
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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Xuan Li
Xuan Li
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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Shaohua Sun
Shaohua Sun
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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Jian-ping Liu
Jian-ping Liu
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China
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currently believed that the mechanism of action of serum CLU in metabolic diseases may be through several pathways. First, CLU may be an anorexia-inducing factor, and the key factor through which the hypothalamus controls energy metabolism. Animal studies
Meihua Jin
Meihua Jin
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Woo Kyung Lee
Woo Kyung Lee
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Mi-Hyeon You
Mi-Hyeon You
Asan Institute of Life Science, Asan Medical Center, Seoul, Korea
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Ahreum Jang
Ahreum Jang
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Sheue-yann Cheng
Sheue-yann Cheng
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
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Won Gu Kim
Won Gu Kim
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Min Ji Jeon
Min Ji Jeon
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Yu-Mi Lee
Yu-Mi Lee
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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A , Shmt2: a Stat3 signaling new player in prostate cancer energy metabolism . Cells 2019 8 1048. ( https://doi.org/10.3390/cells8091048 ) 16 Sung TY Kim M Kim TY Kim WG Park Y Song DE Park SY Kwon H Choi YM Jang EK
Monika Karczewska-Kupczewska
Monika Karczewska-Kupczewska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Agnieszka Nikołajuk
Agnieszka Nikołajuk
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Radosław Majewski
Radosław Majewski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Remigiusz Filarski
Remigiusz Filarski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Magdalena Stefanowicz
Magdalena Stefanowicz
Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Natalia Matulewicz
Natalia Matulewicz
Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Marek Strączkowski
Marek Strączkowski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland
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Karim Gariani
Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Wiebke Arlt
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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the Society for Endocrinology Clinical Committee
the Society for Endocrinology Clinical Committee
The Society for Endocrinology, 22 Apex Court, Woodlands, Bradley Stoke, Bristol, UK
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higher risk of adrenal crisis. Clinical presentation Clinical signs and symptoms : Fatigue, lack of energy, weight loss Low blood pressure, postural dizziness and hypotension (≥20 mmHg drop in BP from supine to standing position), dizziness
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Isala, Diabetes Centre, Zwolle, The Netherlands
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Isala, Diabetes Centre, Zwolle, The Netherlands
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Diakonessenhuis, Department of Internal Medicine, Utrecht, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
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K H Groenier
Isala, Diabetes Centre, Zwolle, The Netherlands
Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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B H R Wolffenbuttel
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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R O B Gans
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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N Kleefstra
Isala, Diabetes Centre, Zwolle, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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H J G Bilo
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Jia Li
Jia Li
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
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Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
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Yan Zhao
Yan Zhao
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Caoxin Huang
Caoxin Huang
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Zheng Chen
Zheng Chen
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Xiulin Shi
Xiulin Shi
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Long Li
Long Li
Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
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Zhong Chen
Zhong Chen
Department of Electronic Science, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
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Xuejun Li
Xuejun Li
Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China
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.7 (8.5) Total energy intake (kcal/day) 2140.7 (458.0) 2124.8 (454.4) Fat intake (%) 33.3 (6.9) 31.9 (7.3) Waist circumference (cm) 96.1 (6.9) 95.2 (7.4) Weight (kg) 72.1 (8.5) 71.7 (10.1) BMI 28.0 (2
