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B Shahida Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden

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P Sahlstrand Johnson Department of Oto-Rhino-Laryngology, Skåne University Hospital, Malmö, Sweden
Department of Clinical Sciences, Lund University, Malmö, Sweden

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R Jain Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden

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H Brorson Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Plastic Surgery, Skåne University Hospital, Malmö, Sweden

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P Åsman Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden

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M Lantz Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden

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T Planck Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden

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in parallel with expression of early adipogenic and inflammatory genes CYR61 and COX2 and cytokines IL6 and IL-1β. In late adipogenesis, upregulation of SCD and PPAR-γ was demonstrated. Simvastatin decreased the expression of all these genes after

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0319
Volume/Issue:
Volume 8: Issue 9
Open access
Julia Modesto Vicente Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Junia Carolina Santos-Silva Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Caio Jordão Teixeira Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Dailson Nogueira de Souza Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Jean Franciesco Vettorazzi Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Fabiola Sales Furtuoso Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Isabel Gouveia Adabo Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Fabio Takeo Sato Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Marco Aurélio Ramirez Vinolo Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Everardo Magalhães Carneiro Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil

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Silvana Bordin Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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Gabriel Forato Anhê Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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) that induce insulin resistance in peripheral insulin-sensitive tissues ( 17 ). Importantly, accumulated evidence also indicates that these cytokines chronically impair pancreatic β-cell function ( 18 , 19 , 20 ). Aiming to elucidate if the increased

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0020
Volume/Issue:
Volume 9: Issue 4
Open access
Kristin Ottarsdottir Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Anna G Nilsson Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden

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Margareta Hellgren Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Ulf Lindblad Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Bledar Daka Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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cytokines, leptin, estradiol and insulin. These substances may inhibit the activity of the hypothalamic–pituitary gonadal axis at multiple levels, thus lowering the concentrations of testosterone ( 7 ). There is also evidence that obesity increases aromatase

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0480
Volume/Issue:
Volume 7: Issue 12
Open access
Yessica Agudelo-Zapata Division of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Luis Miguel Maldonado-Acosta Division of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Héctor Fabio Sandoval-Alzate Department of Human Nutrition, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Natalia Elvira Poveda Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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María Fernanda Garcés Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Jonathan Alexander Cortés-Vásquez Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Andrés Felipe Linares-Vaca Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Carlos Alejandro Mancera-Rodríguez Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Shahar Alexandra Perea-Ariza Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Karen Yuliana Ramírez-Iriarte Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Camilo Andrés Castro-Saldarriaga Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Juan Manuel Arteaga-Diaz Division of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Roberto Franco-Vega Division of Endocrinology, Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Edith Ángel-Müller Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Arturo José Parada-Baños Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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Jorge E Caminos Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia

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increase in pro-inflammatory cytokines and a decrease in the calcium absorption ( 3 ). Additionally, leptin has been shown to be a hormone that rises significantly during preeclampsia, and several authors in observational studies have described a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0055
Volume/Issue:
Volume 7: Issue 5
Open access
Yukari Maki Department of Pediatric Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Kiyomi Horiuchi Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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Takahiro Okamoto Department of Endocrine Surgery, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

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. proposed the following hypotheses: anaemia, ATP dysregulation, vagal afferent nerve activation, and interaction of the hypothalamic–pituitary–adrenal axis/cytokines with serotonin dysregulation ( 32 , 33 ). Of these, Bower focused on the cytokine

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0506
Volume/Issue:
Volume 11: Issue 2
Open access
Ru-Xuan Zhao Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Ting-Ting Shi Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Sha Luo Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Yun-Fu Liu Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Zhong Xin Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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Jin-Kui Yang Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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activity. Lacrimal acinar cells express TSHR ( 12 ), and the expression of ICAM-1 in lacrimal gland epithelial cells and lymphocytes in GO patients is significantly elevated in relation to the normal control group ( 13 ). A study of cytokines and chemokines

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0590
Volume/Issue:
Volume 11: Issue 2
Open access
Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Tao Tong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Zheng Li Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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cell membrane. The growth hormone receptor belongs to the cytokine receptor superfamily and is abundantly expressed in B lymphocytes and less frequently in T lymphocytes ( 25 , 26 ). Evidence from previous studies suggests that GH enhances T cell

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0439
Volume/Issue:
Volume 13: Issue 4
Open access
Yunyi Ding Department of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Siyao Lv Department of Gastroenterology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Ruijie Xie Division of Clinical Epidemiology and Aging Research, University of Heidelberg, Heidelberg, Germany

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Wei Ye Department of Gastroenterology, Hangzhou TCM Hospital, Hangzhou, China

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Yichen Luo School of Mechanical Engineering, Zhejiang University, Hangzhou, China

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Yayu Li Department of Nephrology, Hangzhou TCM Hospital, Hangzhou, China

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lower than that of nonobese patients, and DKD is more likely to occur. Another example of an inflammatory factor is tumor necrosis factor (TNF), which is a multifunctional proinflammatory cytokine and plays a role in lipid metabolism, lipid accumulation

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0491
Volume/Issue:
Volume 13: Issue 4
Open access
Stefano Mangiola Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Ryan Stuchbery Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia

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Patrick McCoy Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Ken Chow Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Natalie Kurganovs Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia
Ontario Institute for Cancer Research, Toronto, Canada
Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

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Michael Kerger Australian Prostate Cancer Research Centre Epworth, Richmond, Victoria, Australia

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Anthony Papenfuss Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia
Department of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia

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Christopher M Hovens Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia

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Niall M Corcoran Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia
Department of Urology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Urology, Frankston Hospital, Frankston, Victoria, Australia

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boundaries ( 50 ). Periprostatic adipose tissue has been shown to elaborate a number of cytokines including IL6, osteopontin, and TNF-alpha, that promote prostate tumour cell migration and invasion ( 51 , 52 ), and at least for IL6 correlates with downstream

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0029
Volume/Issue:
Volume 8: Issue 5
Open access
Caio Jordão Teixeira Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Junia Carolina Santos-Silva Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Dailson Nogueira de Souza Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Alex Rafacho Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil

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Gabriel Forato Anhe Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Silvana Bordin Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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polarization, which is characterized by low levels of inflammatory cytokines such as IL-1, TNF-α and IL-6, has been previously demonstrated to be induced by glucocorticoids ( 37 ). In the context of pancreatic islets, M2 infiltration promotes cell proliferation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0505
Volume/Issue:
Volume 8: Issue 2
Open access