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.ghir.2008.08.001 ) 18 Marshall WA Tanner JM . Variations in pattern of pubertal changes in girls . Archives of Disease in Childhood 1969 44 291 – 303 . ( https://doi.org/10.1136/adc.44.235.291 ) 19 Marshall WA Tanner JM . Variations in
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Utriainen P Jääskeläinen J Romppanen J Voutilainen R Childhood metabolic syndrome and its components in premature adrenarche . Journal of Clinical Endocrinology and Metabolism 2007 92 4282 – 4285 . ( https://doi.org/10.1210/jc.2006-2412 ) 9
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.1159/000281323 6 Kappoor R Burke S Sparrow S Hughes I Dunger D Ong K Acerini C. Monitoring of concordance in growth hormone therapy . Archives of Disease in Childhood 2008 93 147 – 148 . ( https://doi.org/10.1136/adc.2006.114249 ) 10.1136/adc
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Introduction Type 1 diabetes is one of the most common chronic diseases in childhood. The incidence rate has been rising throughout the Western world ( 1 ). The incidence is highest in Finland, in 2006 as high as 64.3 per 100,000 children
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adrenal rest tumors (TARTs) which may be present already in childhood and adolescence ( 4 ). The presence of TART constitutes a diagnostic and management challenge. Usually, TARTs are bilaterally localized, benign tumors that have been assumed to derive
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. Figure 1 Hand X-rays of patients A-1 in childhood and adulthood and B-1 in adulthood. Unlike in B-1, there is severe shortening of metacarpal and phalangeal bones and cone-shaped epiphyses in case A-1, in which a PDE4D pathogenic variant was
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‘Are you on testosterone therapy at present? SC Yes No Age at diagnosis ‘At what age was your condition diagnosed?’ SC Before birth At birth (0–1 month) Infancy (1 month–3 years) Childhood (4
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-Mayer DE . Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood . Pediatrics 2007 120 e179 – e188 . ( https://doi.org/10.1542/peds.2006-3324 ) 3 Bougneres P Pantalone L Linglart A
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. Further studies are necessary to clarify whether sex hormone production in childhood is associated with sexual maturation during puberty or reproductive function in adulthood. In conclusion, the results show that sexual dimorphism in sex hormone
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during foetal development. Common clinical presentations include inguinal or labial hernia in childhood or primary amenorrhoea in adolescence ( 1 ). CAIS may also present through screening after a family member is affected or discordance between prenatal