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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Laboratório Central de Análises Clínicas, Hospital de Clínicas, Universidade Federal do Paraná, Centro, Curitiba, Paraná, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Departamento de Saúde Coletiva, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
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Utriainen P Jääskeläinen J Romppanen J Voutilainen R Childhood metabolic syndrome and its components in premature adrenarche . Journal of Clinical Endocrinology and Metabolism 2007 92 4282 – 4285 . ( https://doi.org/10.1210/jc.2006-2412 ) 9
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.1159/000281323 6 Kappoor R Burke S Sparrow S Hughes I Dunger D Ong K Acerini C. Monitoring of concordance in growth hormone therapy . Archives of Disease in Childhood 2008 93 147 – 148 . ( https://doi.org/10.1136/adc.2006.114249 ) 10.1136/adc
Surgery Research Unit, Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
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Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
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Pediatric Research Center, New Children’s Hospital, Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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Introduction Type 1 diabetes is one of the most common chronic diseases in childhood. The incidence rate has been rising throughout the Western world ( 1 ). The incidence is highest in Finland, in 2006 as high as 64.3 per 100,000 children
International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Pediatric Endocrinology Clinic, Department of Pediatrics, Aretaeio Hospital, Nicosia, Cyprus
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Denmark
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adrenal rest tumors (TARTs) which may be present already in childhood and adolescence ( 4 ). The presence of TART constitutes a diagnostic and management challenge. Usually, TARTs are bilaterally localized, benign tumors that have been assumed to derive
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. Figure 1 Hand X-rays of patients A-1 in childhood and adulthood and B-1 in adulthood. Unlike in B-1, there is severe shortening of metacarpal and phalangeal bones and cone-shaped epiphyses in case A-1, in which a PDE4D pathogenic variant was
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‘Are you on testosterone therapy at present? SC Yes No Age at diagnosis ‘At what age was your condition diagnosed?’ SC Before birth At birth (0–1 month) Infancy (1 month–3 years) Childhood (4
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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-Mayer DE . Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood . Pediatrics 2007 120 e179 – e188 . ( https://doi.org/10.1542/peds.2006-3324 ) 3 Bougneres P Pantalone L Linglart A
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
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Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
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Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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. Further studies are necessary to clarify whether sex hormone production in childhood is associated with sexual maturation during puberty or reproductive function in adulthood. In conclusion, the results show that sexual dimorphism in sex hormone
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during foetal development. Common clinical presentations include inguinal or labial hernia in childhood or primary amenorrhoea in adolescence ( 1 ). CAIS may also present through screening after a family member is affected or discordance between prenatal
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Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
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childhood and even into adulthood, with potentially clinically relevant endpoints. We summarized potential points of interference and endpoints in Fig. 2 . The current review will focus mainly on brain development as most follow-up studies have focused on