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, 24 ). About 40% of mitotane is absorbed through the intestine, and then binds to lipophilic proteins and is metabolized in the liver. It accumulates in adipose tissue from where it can be released for weeks to months ( 24 , 25 ), making it difficult
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was updated in 2017 ( 8 ). This later guidance noted that subjects’ ethnicity, location and adiposity, in particular, affected the upper limits of ‘normal’ thyroid function, as expressed by the reference range. As a result, the US guidelines advocate
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in adipose tissue development or function (lipodystrophy (LD)) or primary disorders of insulin signaling ( 1 , 2 , 3 ). LDs are rare heterogeneous disorders characterized by selective loss of body fat and can be divided into congenital and
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distribution of adipose tissue. In obese males, the pattern differs as leptin levels increase and may be responsible in part for the suppression of the HPG axis. An alternative explanation suggests that it is perhaps the increased aromatase activity of the
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