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Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff and Michael Beckert

with insulin-like growth factor 1 (IGF1), leads to abnormal body composition and metabolism as well as psychological impairment ( 1 , 2 ). Left untreated, AGHD is associated with decreased bone mineral density, increased risk of cardiovascular

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Elizaveta Mamedova, Natalya Mokrysheva, Evgeny Vasilyev, Vasily Petrov, Ekaterina Pigarova, Sergey Kuznetsov, Nikolay Kuznetsov, Liudmila Rozhinskaya, Galina Melnichenko, Ivan Dedov and Anatoly Tiulpakov

). The majority of studies on special features of PHPT in young patients demonstrate that in comparison with elderly patients the former have greater morbidity (i.e. symptomatic hypercalcemia, nephrolithiasis, severe bone involvement and nonspecific

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Hanbaro Kim, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Shadi Alshammary and Song Cheol Kim

common organ associated with recurrence was the liver. Of 62 patients with liver metastasis, 5 also experienced simultaneous recurrence in the peritoneum, 1 in the remaining pancreas, 1 in the lung and supraclavicular lymph node and 1 in bone. Of the 12

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Aaron Lerner, Patricia Jeremias and Torsten Matthias

’s thyroiditis Graves’ disease Weight Loss Gain Loss Bowel movement Diarrhea/constipation Constipation Diarrhea Joint/bone pain +/+ +/−, hypotonia Muscle weakness Fatigue/tiredness + + + Psychology

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Louise Færch, Anders Juul, Ulrik Pedersen-Bjergaard and Birger Thorsteinsson

muscle and bone turnover as well as lipid metabolism and growth (23, 24, 25) , and our study supports that a low IGF1 level in patients with type 1 diabetes may increase by lowering HbA1c and thereby diminish the negative influence of a low IGF1 on the

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Sandrine Visentin, Gérard Michel, Claire Oudin, Béatrice Cousin, Bénédicte Gaborit, Inès Abdesselam, Marie Maraninchi, Marion Nowicki, René Valéro, Maxime Guye, Monique Bernard, Pascal Auquier, Hervé Chambost, Marie-Christine Alessi and Sophie Béliard

, Health status and quality of life in long-term survivors of childhood leukaemia: the impact of haematopoietic stem cell transplantation . Bone Marrow Transplantation 2007 40 897 – 904 . ( https://doi.org/10.1038/sj.bmt.1705821 ) 10.1038/sj

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Anna Malczewska, Magdalena Witkowska, Karolina Makulik, Agnes Bocian, Agata Walter, Joanna Pilch-Kowalczyk, Wojciech Zajęcki, Lisa Bodei, Kjell Oberg and Beata Kos-Kudła

extent evaluation Overall, IPD (any modality) was present in 75: PNETs ( n  = 42) – primary in situ /local recurrence ( n  = 26), lymph node metastases ( n  = 21), distant metastases (liver and/or bone, other: n  = 23), SINETs ( n  = 33): primary in

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Anne H van der Spek, Olga V Surovtseva, Saskia Aan, Anton T J Tool, Annemarie van de Geer, Korcan Demir, Anja L M van Gucht, A S Paul van Trotsenburg, Timo K van den Berg, Eric Fliers and Anita Boelen

, bone and inflammatory cells ( 3 , 4 , 5 , 6 , 7 , 8 , 9 ). There are two ligand-binding TRβ isoforms: TRβ1, which is mainly present in the brain, liver and kidney, and TRβ2, which is expressed in the hypothalamus and pituitary ( 1 , 2

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J Brossaud, V Pallet and J-B Corcuff

apparently opposite effect has been shown in tumoural cells as RA reduces growth and secretion of AtT20 cells ( 61 ) possibly through bone morphogenic protein 4 action ( 61 , 62 , 63 , 64 ). This explains recent papers about the possible use of retinoids

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Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch and Elisabeth Lerchbaum

important public health problem ( 2 ). Vitamin D has been well known for its role in maintaining calcium homeostasis and promoting bone mineralization ( 2 ). Beyond the established relationship between vitamin D deficiency and musculoskeletal diseases