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Agnieszka Kosowska Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Enrique Gallego-Colon Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Wojciech Garczorz Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Agnieszka Kłych-Ratuszny Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Mohammad Reza F Aghdam Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Michał Woz´niak Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Andrzej Witek Department of Gynaecology and Obstetrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Agnieszka Wróblewska-Czech Department of Gynaecology and Obstetrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Anna Cygal Department of Gynaecology and Obstetrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Jerzy Wojnar Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Tomasz Francuz Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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changes were observed in inflammatory cytokines such as IL-6 and IL-8 (Supplementary data 1, see section on supplementary data given at the end of this article). Interestingly, endothelial cells from aorta, coronary artery and iliac artery showed

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Sarantis Livadas Endocrine Unit, Athens Medical Centre, Athens, Greece

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Christina Bothou Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital of Zurich, Zurich, Switzerland

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Justyna Kuliczkowska-Płaksej Department of Endocrinology, Diabetology and Isotope Therapy, University of Medicine, Wrocław, Poland

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Ralitsa Robeva Ushate ‘acad. IV. Penchev’, Department of Endocrinology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria

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Andromahi Vryonidou Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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Jelica Bjekic Macut Department of Endocrinology, UMC Bežanijska Kosa, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Ioannis Androulakis Endocrine Unit, Athens Medical Centre, Athens, Greece

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Milica Opalic Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Zadalla Mouslech 1st Medical Propedeutic, Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Andrej Milewicz Department of Endocrinology, Diabetology and Isotope Therapy, University of Medicine, Wrocław, Poland

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Alessandra Gambineri Department of Medical and Surgical Science-DIMEC Endocrinology Unit, University of Bologna – S. Orsola-Mapighi Hospital, Italy

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Dimitrios Panidis Gynaecological Endocrinology Infirmary of the Second Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Djuro Macut Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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volume in women with PCOS and controls. PCOS ( n   = 1614) Controls ( n   = 362) P Age (years) 25.14 ± 5.56 30.36 ± 5.96 0.027 BMI (kg/m 2 ) 27.34 ± 7.09 25.49 ± 5.97 <0.001 WHR 0.79 ± 0.08 0.78 ± 0

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Mieke Van Hemelrijck
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Thurkaa Shanmugalingam
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Cecilia Bosco
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Wahyu Wulaningsih
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Sabine Rohrmann Cancer Epidemiology Group, Division of Chronic Disease Epidemiology, Division of Cancer Studies, King's College London, London, UK

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.38) 91.21 (1.06) BMI (kg/m 2 )  Mean ( s.e.m .) 26.7 (0.66) 26.77 (0.17) 26.32 (0.41) Cigarette smoking (%)  Never 41.52 46.91 40.55  Former 30.21 25.88 34.05  Current 28.26 27.21 25.40 Alcohol intake (%)  Up to once a week 67.48 63.96 66.89  Two to

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Filomena Cetani Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Chiara Banti Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Elena Pardi Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Simona Borsari Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Paolo Viacava Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Paolo Miccoli Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Liborio Torregrossa Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Fulvio Basolo Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Maria Rosa Pelizzo Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Massimo Rugge Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Gianmaria Pennelli Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Guido Gasparri Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Mauro Papotti Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Marco Volante Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Edda Vignali Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Federica Saponaro Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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Claudio Marcocci Department of Clinical and Experimental Medicine, Section of Pathology, Department of Surgical, Surgery Unit, Medicine, General Surgery 3 and Esophageal Surgery, Clinical and Biological Sciences, Department of Oncology

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>A exon 2 L61X <5 Dead of disease 2  23 M 60 NA NA + Yes WT WT <5 Dead of disease 2  27 F 56 14.5 554 + No c.343G>T exon 4 (G) b E115X 10 Dead of disease 11 c.64G>T exon 1 G22X  28 M 40 14.0 96 − No WT WT <5 Dead of disease 4  34 M 57 NA 2243 NA No WT WT

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Sara Storvall Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Helena Leijon Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Eeva Ryhänen Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Louhimo Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Caj Haglund Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Camilla Schalin-Jäntti Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Arola Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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tumors Negative tumors P value Ki-67 (%) 5.8 (0–30) 3.1 (0–40) 0.069 Tumor size (cm) 2.48 (1.0–4.0) 2.0 (1.0–5.0) 0.142 S-Ca-ion (mmol/L) 1.69 (1.38–2.42) 1.56 (1.28–2.58) 0.098 S-PTH (ng/l) 727 (34

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Iulia Soare University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania

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Anca Sirbu University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Endocrinology, Diabetes and Metabolic diseases, Elias Hospital, Bucharest, Romania

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Mihai Mircea Diculescu University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Gastroenterology, Fundeni Clinical Institute, Bucharest, Romania

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Bogdan Radu Mateescu University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Gastroenterology, Colentina Hospital, Bucharest, Romania

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Cristian Tieranu University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Gastroenterology, Elias Hospital, Bucharest, Romania

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Sorina Martin University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Endocrinology, Diabetes and Metabolic diseases, Elias Hospital, Bucharest, Romania

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Carmen Gabriela Barbu University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Endocrinology, Diabetes and Metabolic diseases, Elias Hospital, Bucharest, Romania

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Mirela Ionescu University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Gastroenterology, Elias Hospital, Bucharest, Romania

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Simona Fica University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Bucharest, Romania
Department of Endocrinology, Diabetes and Metabolic diseases, Elias Hospital, Bucharest, Romania

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) 42 (23) 44 (27) NS Age at diagnosis, years 32 ± 14.5 34.1 ± 14.9 33.8 ± 14 NS Disease duration, years 7 (10) 8 (6) 10.3 (13) NS 25-hydroxy vitamin D, ng/mL 20.7 ± 7.6 19.9 ± 7.6 21.4 ± 7.04 NS Lumbar

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V Guarnotta Dipartimento di Promozione della Salute, Materno – Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy

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C Di Stefano Dipartimento di Promozione della Salute, Materno – Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy

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A Santoro Dipartimento di Promozione della Salute, Materno – Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy

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A Ciresi Dipartimento di Promozione della Salute, Materno – Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy

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A Coppola Dipartimento di Promozione della Salute, Materno – Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy

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C Giordano Dipartimento di Promozione della Salute, Materno – Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy

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.91 0.062  Fasting glycaemia (mmol/L) 5.46 ± 3.13 5.40 ± 3.2 5.51 ± 3.12 0.886  HbA1c (mmol/mol) 41.3 ± 20.2 34.9 ± 21.6 47.4 ± 17 0.002 a P value between patients in group A and B at baseline. At

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Maria Luisa Brandi Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
Fondazione Italiana Ricerca sulle Malattie dell’Osso (FIRMO Onlus), Florence, Italy

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Stefania Bandinelli Geriatric Unit, Azienda Sanitaria Toscana Centro, Florence, Italy

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Teresa Iantomasi Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Francesca Giusti Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Eleonora Talluri Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Giovanna Sini Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Fabrizio Nannipieri Clinical Research, Abiogen Pharma, Pisa, Italy

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Santina Battaglia Clinical Research, Abiogen Pharma, Pisa, Italy

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Riccardo Giusti Clinical Research, Abiogen Pharma, Pisa, Italy

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Colin Gerard Egan CE Medical Writing SRLS, Pisa, Italy

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Luigi Ferrucci Longitudinal Study Section, Translation Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA

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.1 5.5 ± 2.8 5.6 ± 3.4 0.83  VDBP (mg/L) 698.2 ± 200.9 736.3 ± 223.3 647.8 ± 150.4 0.0001  Creatinine (mg/dL) 0.89 ± 0.53 0.75 ± 0.49 1.06 ± 0.53 <0.0001  BPA (ng/dL) 351.2 ± 511.6 337.5 ± 507.7 368.2 ± 517

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Sriharsha Gunna Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Mahaveer Singh Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Rakesh Pandey Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Rungmei S K Marak Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Amita Aggarwal Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Bibhuti Mohanta Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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Liping Yu Barbara Davis Centre for Diabetes, School of Medicine University of Colorado, Aurora, Colorado, USA

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Eesh Bhatia Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

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.3–13.9) 0.7 (0.3–7.5) 0.55 Pyrexia 44 (49%) 29 (73%) b 8 (62%) d 2 (9%) 5 (36%) <0.001 Weight loss 86 (98%) 39 (97.5%) 13 (100%) 20 (95%) 14 (100%) 0.46 Mucocutaneous hyperpigmentation 79 (89%) 34 (85%) 13

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Nannan Bian Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Xiaomeng Sun Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Biao Zhou Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

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Lin Zhang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Qiu Wang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Yu An Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Xiaohui Li Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Yinhui Li Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Jia Liu Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Hua Meng Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

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Guang Wang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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.9%) 37 (57.8%) a 91 (61.9%) a 0.003 BMI (kg/m 2 ) 22.4 (21.3–23.4) 27.7 (26.2–29.0) a 38.2 (34.1–43.0) a,b 0.000 Dyslipidemia 25 (32.9%) 21 (32.8%) 64 (43.5%) 0.187 Triglyceride (mmol/L) 1.09 (0.82–1.52) 1.54 (1

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