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changes were observed in inflammatory cytokines such as IL-6 and IL-8 (Supplementary data 1, see section on supplementary data given at the end of this article). Interestingly, endothelial cells from aorta, coronary artery and iliac artery showed
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volume in women with PCOS and controls. PCOS ( n = 1614) Controls ( n = 362) P Age (years) 25.14 ± 5.56 30.36 ± 5.96 0.027 BMI (kg/m 2 ) 27.34 ± 7.09 25.49 ± 5.97 <0.001 WHR 0.79 ± 0.08 0.78 ± 0
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.38) 91.21 (1.06) BMI (kg/m 2 ) Mean ( s.e.m .) 26.7 (0.66) 26.77 (0.17) 26.32 (0.41) Cigarette smoking (%) Never 41.52 46.91 40.55 Former 30.21 25.88 34.05 Current 28.26 27.21 25.40 Alcohol intake (%) Up to once a week 67.48 63.96 66.89 Two to
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>A exon 2 L61X <5 Dead of disease 2 23 M 60 NA NA + Yes WT WT <5 Dead of disease 2 27 F 56 14.5 554 + No c.343G>T exon 4 (G) b E115X 10 Dead of disease 11 c.64G>T exon 1 G22X 28 M 40 14.0 96 − No WT WT <5 Dead of disease 4 34 M 57 NA 2243 NA No WT WT
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tumors Negative tumors P value Ki-67 (%) 5.8 (0–30) 3.1 (0–40) 0.069 Tumor size (cm) 2.48 (1.0–4.0) 2.0 (1.0–5.0) 0.142 S-Ca-ion (mmol/L) 1.69 (1.38–2.42) 1.56 (1.28–2.58) 0.098 S-PTH (ng/l) 727 (34
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Department of Endocrinology, Diabetes and Metabolic diseases, Elias Hospital, Bucharest, Romania
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) 42 (23) 44 (27) NS Age at diagnosis, years 32 ± 14.5 34.1 ± 14.9 33.8 ± 14 NS Disease duration, years 7 (10) 8 (6) 10.3 (13) NS 25-hydroxy vitamin D, ng/mL 20.7 ± 7.6 19.9 ± 7.6 21.4 ± 7.04 NS Lumbar
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.91 0.062 Fasting glycaemia (mmol/L) 5.46 ± 3.13 5.40 ± 3.2 5.51 ± 3.12 0.886 HbA1c (mmol/mol) 41.3 ± 20.2 34.9 ± 21.6 47.4 ± 17 0.002 a P value between patients in group A and B at baseline. At
Fondazione Italiana Ricerca sulle Malattie dell’Osso (FIRMO Onlus), Florence, Italy
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.1 5.5 ± 2.8 5.6 ± 3.4 0.83 VDBP (mg/L) 698.2 ± 200.9 736.3 ± 223.3 647.8 ± 150.4 0.0001 Creatinine (mg/dL) 0.89 ± 0.53 0.75 ± 0.49 1.06 ± 0.53 <0.0001 BPA (ng/dL) 351.2 ± 511.6 337.5 ± 507.7 368.2 ± 517
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.3–13.9) 0.7 (0.3–7.5) 0.55 Pyrexia 44 (49%) 29 (73%) b 8 (62%) d 2 (9%) 5 (36%) <0.001 Weight loss 86 (98%) 39 (97.5%) 13 (100%) 20 (95%) 14 (100%) 0.46 Mucocutaneous hyperpigmentation 79 (89%) 34 (85%) 13
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.9%) 37 (57.8%) a 91 (61.9%) a 0.003 BMI (kg/m 2 ) 22.4 (21.3–23.4) 27.7 (26.2–29.0) a 38.2 (34.1–43.0) a,b 0.000 Dyslipidemia 25 (32.9%) 21 (32.8%) 64 (43.5%) 0.187 Triglyceride (mmol/L) 1.09 (0.82–1.52) 1.54 (1