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Zhenzhen Wang Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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Xiangying Zhu Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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Xiaohui Yu Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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Haixia Guan Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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Lei Zhao Department of Ultrasonography, The First Affiliated Hospital of China Medical University, Shenyang, China

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Yixia Zhang Department of Ultrasonography, The First Affiliated Hospital of China Medical University, Shenyang, China

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Yuge Li Department of Ultrasonography, The First Affiliated Hospital of China Medical University, Shenyang, China

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Liang Sang Department of Ultrasonography, The First Affiliated Hospital of China Medical University, Shenyang, China

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Yuchen Han Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

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Yushu Li Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China

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factors for thyroid nodule malignancy in China. In this study, we analyzed 274 nodules of 196 patients with ultrasound-guided FNA results, compared ATA classification with histopathology results, and discussed the diagnostic efficiency of the ATA

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Rong Xu Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Difei Lian Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yan Xie Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Lin Mu Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yali Wu Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Zhilei Chen Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Baoyu Zhang Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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cross-sectional study in Iranian adolescents (221 girls and 192 boys) aged 9–19 years showed that sUA was associated with BMD and bone mineral content at all sites, with higher BMD in adolescents with higher UA levels ( 25 ). In Chinese adolescents aged

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Lianghui You Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China

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Yan Wang Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China

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Yao Gao Department of Endocrinology, Children’s Hospital of Nanjing Medical University, Nanjing, China

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Xingyun Wang Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Xianwei Cui Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Yanyan Zhang Beijing Chaoyang Distirct Maternal and Child Health Care Hospital, Beijing, China

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Lingxia Pang Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Chenbo Ji Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China

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Xirong Guo Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xia Chi Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China

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was carried out by RIBOBIO Co. Ltd (Guangzhou, China) in accordance with the manufacturer’s instructions. Briefly, small RNAs ranging from 18 nt to 30 nt in size were purified with gel and ligated to the 3′ adaptor and 5′adaptor. Subsequently, ligation

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Jingci Chen Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Yan Wu Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Pengyan Wang Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Huanwen Wu Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Anli Tong Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People’s Republic of China, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Xiaoyan Chang Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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in our cohort. Materials and methods Clinicopathological information Eighteen CP cases were diagnosed between February 2005 and June 2020 in Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences. The

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Ling Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Endocrinology and Metabolism, People's Hospital of Liaoning Province, Shenyang, People’s Republic of China

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Yingying Zhou Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Shiqiao Peng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Xinyi Wang Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China
Department of Laboratory Medical, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People’s Republic of China

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–7 weeks old), were maintained on a 12:12-h light/darkness cycle and fed normal rat chow ad libitum . All animals and experimental procedures were approved by the Animal Care and Use Committee at China Medical University, which complied with the National

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Feifei Shao Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China
Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Xinxin Hu Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Jiayu Li Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Bona Bai Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China
Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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65–79 years; furthermore, in 2017, there were 122 million adults aged ≥65 years with diabetes mellitus worldwide, and this number is projected to reach 253 million in 2045 ( 1 ). China has the largest number of elderly people diagnosed with diabetes

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Xingrong Tan Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

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Wenjing Hu Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing, China

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Shan Yang Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Han Dai Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Shangcheng Xu Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing, China

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Gangyi Yang Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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Ling Li Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

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Shiguo Tang Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

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Yi Wang Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

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Research population This study was performed between March 2018 and July 2019 in The Second Affiliated Hospital, Chongqing Medical University, China. A total of 196 young women (aged 20–35 years) from the community, university, and normal physical

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Anru Wang Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Xueqin Yan Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China

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Cai Zhang Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caiqi Du Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Wenjun Long Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Di Zhan Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiaoping Luo Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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were 45 boys and 43 girls. Obesity was defined as age- and sex-specific BMI of greater than or equal to 95th percentile in accordance with the growth charts for children in China ( 9 ). BMI values were converted to standard deviation score (SDS) values

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Yun Hu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
Department of Immunology, Nanjing Medical University, Jiangsu, China

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Na Li Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Peng Jiang Department of Thyroid and Breast Surgery, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Liang Cheng Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Bo Ding Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Xiao-Mei Liu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Ke He Department of Endocrinology, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu, China

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Yun-Qing Zhu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Bing-li Liu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Xin Cao Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Hong Zhou Department of Immunology, Nanjing Medical University, Jiangsu, China

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Xiao-Ming Mao Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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were also collected at Nanjing First Hospital; these were confirmed by pathology. The indications for operation are according to the Chinese Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer (2012) ( 27 ). Besides

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Xuan Luo Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Tingting Zheng Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Chaoming Mao Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Xin Dong Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Xiao Mou Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Chengcheng Xu Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Qingyan Lu Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Baocui Liu Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

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Shengjun Wang Department of Laboratory Immunology, Jiangsu University School of Medicine, Zhenjiang, China

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Yichuan Xiao Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China

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streptavidin peroxidase-conjugated secondary antibody (Maixin Biotechnology Co., Ltd., Fuzhou, China). Tissue sections were then counterstained with 3,3′-diaminobenzidine and haematoxylin and observed under an optical microscope. Immunoblots Total

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