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Marcus Quinkler Endocrinology in Charlottenburg, Berlin, Germany

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Bertil Ekman Departments of Endocrinology and Medical and Health Sciences, Linköping University, Linköping, Sweden

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Claudio Marelli Shire International GmbH, Zug, Switzerland

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Sharif Uddin Shire, Lexington, Massachusetts, USA

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Pierre Zelissen Department of Internal Medicine and Endocrinology, University Medical Center Utrecht, Utrecht, the Netherlands

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Robert D Murray Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James’s University Hospital, Leeds, UK

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on behalf of the EU-AIR Investigators
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prednisolone and cardio­vascular risk are derived only from studies with patients with rheumatoid arthritis, who generally receive higher doses of prednisolone than those used in this study (>7.5 mg/day). A recent systematic literature review on cardiovascular

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Sandeep Kumar Parvathareddy Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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Abdul K Siraj Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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Zeeshan Qadri Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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Saeeda O Ahmed Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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Felisa DeVera Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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Saif Al-Sobhi Department of Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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Fouad Al-Dayel Department of Pathology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Khawla S Al-Kuraya Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

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.6  No 941 79.4 Recurrence  Yes 275 19.5  No 1132 80.5 ATA risk category  Low 231 16.4  Intermediate 460 32.7  High 716 50.9 Lymph node ratio cut-off LNR was

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Kaiyu Pan Department of Paediatrics, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China

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Chengyue Zhang Xiangya School of Medicine, Central South University, Changsha, Hunan, China

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Xiaocong Yao Department of Osteoporosis, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China

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Zhongxin Zhu Institute of Orthopaedics and Traumatology of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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risk markers in children with high calcium-phosphorus product . Scientific Reports 2018 8 17864 . ( https://doi.org/10.1038/s41598-018-35973-5 ) 22 Chrysant SG Chrysant GS . Controversy regarding the association of high calcium intake and

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Johanna Christina Penell Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden
Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden

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Mark M Kushnir Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA

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Lars Lind Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden

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Jonatan Bergquist Department of Chemistry – BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden

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Jonas Bergquist Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
Department of Chemistry – BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden

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P Monica Lind Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden

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Tord Naessen Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

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the median in all women, whereas median concentration of testosterone was 5–6.5% higher in healthy women and men, as compared to the entire study population ( Table 3 ). Figure 2 Distributions of endogenous steroids in 70-year-old men and women

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Dorte Glintborg Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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Katrine Hass Rubin OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark

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Mads Nybo Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

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Bo Abrahamsen OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
Department of Medicine, Holbæk Hospital, Holbæk, Denmark

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Marianne Andersen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

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women referred with infertility, irregular menses and/or suspicion of PCOS ( 3 ). Insulin resistance is part of the pathogenesis of PCOS ( 4 ). Insulin resistance increases the risk of metabolic syndrome ( 5 , 6 ) and low-grade inflammation ( 4 ). Low

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Josephina G Kuiper PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands

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Aline C Fenneman Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Anne H van der Spek Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Elena Rampanelli Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Max Nieuwdorp Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Myrthe P P van Herk-Sukel Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands

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Valery E P P Lemmens Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands

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Ernst J Kuipers Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands

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Ron M C Herings PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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, and differentiation ( 3 ). Alterations in TH bioavailability have been implicated in the development of several forms of cancer, including basal cell carcinomas ( 4 ), lung cancer ( 5 , 6 ), and colorectal cancer (CRC) ( 7 ). CRC is one of the world

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Xiaomin Nie Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yiting Xu Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Xiaojing Ma Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yun Shen Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yufei Wang Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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of FT3 within the reference range was related to the risk of NAFLD and multiple adverse metabolic and cardiovascular risk factors ( 5 , 7 , 8 ), which suggests that a high level of FT3 within the reference range may be a potential adverse metabolic

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Rasmus Reinke Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Stefano Christian Londero Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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Martin Almquist Department of Surgery, Lund University Hospital, Lund, Sweden

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Lars Rejnmark Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Lars Rolighed Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark

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) or their vascular supply ( 3 ). HypoPT may reduce quality of life ( 4 ) and increases both mortality ( 5 ) and morbidity ( 6 ). Morbidity for patients with hypoPT includes an increased risk of developing chronic kidney disease (CKD) and kidney

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Thozhukat Sathyapalan Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

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Anne-Marie Coady Department of Obstetric Ultrasound, Hull and East Yorkshire Women’s and Children’s Hospital, Hull, UK

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Eric S Kilpatrick Department of Clinical Biochemistry, Sidra Medical and Research Center, Doha, Qatar

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Stephen L Atkin Department of Medicine, Weill Cornell Medical College, Doha, Qatar

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(WOSCOPS), pravastatin treatment decreased the risk of type 2 diabetes (T2DM) by 30% ( 3 ). Emerging evidence, however, suggests that treatment with other statins slightly increase the risk of T2DM ( 4 , 5 ). In pooled data sets, statin therapy was

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Lijuan Fu Department of Laboratory, Changyi People’s Hospital of Shandong Province, Changyi, Shandong, China

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Jinhuan Ma Department of Laboratory, Changyi Maternal and Child Health Hospital of Shandong Province, Changyi, Shandong, China

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Sumei Yan Department of Obstetrics, Changyi Maternal and Child Health Hospital of Shandong Province, Changyi, Shandong, China

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Qijun Si Department of Laboratory, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, Zhejiang, China

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analyses All statistical analyses in this meta-analysis were performed with the Cochrane Review Manager software version 5.3 (The Cochrane Collaboration, Software Update, Oxford, United Kingdom). Associations between VDR gene polymorphisms and the risk

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