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Cristina Romei Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Teresa Ramone Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Chiara Mulè Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Alessandro Prete Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Virginia Cappagli Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Loredana Lorusso Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology, University of Pisa, Pisa, Italy

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Fulvio Basolo Department of Surgical, Medical, Molecular Pathology, University of Pisa, Pisa, Italy

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Raffaele Ciampi Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Rossella Elisei Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Introduction Medullary Thyroid Carcinoma (MTC) accounts for about 5–7% of all thyroid cancer and can occur in a hereditary (25%) or a sporadic form (75%) ( 1 ). According to the Next Generation Studies published in the last years ( 2 , 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0589
Volume/Issue:
Volume 10: Issue 2
Open access
Ling Hu Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Ting Li Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Xiao-Ling Yin Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Yi Zou Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Introduction Both solitary and multiple thyroid nodules (TN) are very commonly seen in clinical practice; this is important, because thyroid cancer occurs in approximately 5% of these nodules ( 1 ). Thyroid nodules can also indicate thyroid

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0398
Volume/Issue:
Volume 9: Issue 9
Open access
Xiaoya Zheng Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Shanshan Yu Pathology Department, Chongqing Medical University, Chongqing, China

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Jian Long Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Qiang Wei Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China

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Liping Liu Department of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chun Liu Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Wei Ren Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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to PTL, DSVPTC had a higher incidence of lymph node metastasis (82.5% vs 30.8%, P   < 0.001). There were no significant differences in radiation exposure history or thyroid cancer family history between the two groups ( P   > 0.05). Figure 1

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0364
Volume/Issue:
Volume 11: Issue 1
Open access
Yong Yu Department of Ultrasound, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
Department of Ultrasound, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China

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Lin-Lin Shi Department of Ultrasound, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China

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Hua-Wei Zhang Department of Ultrasound, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China

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Qian Wang Department of Ultrasound, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China

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Introduction Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma, accounting for 84% of all thyroid cancers ( 1 ). The majority of PTCs have a low tumor growth rate and a favorable prognosis, but few of them are highly

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0341
Volume/Issue:
Volume 12: Issue 2
Open access
Giorgio Grani Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Livia Lamartina Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Vito Cantisani UOS Innovazioni Diagnostiche e Ultrasonografiche, Azienda Ospedaliera Universitaria Policlinico Umberto I, ‘Sapienza’ University of Rome, Rome, Italy

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Marianna Maranghi Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Piernatale Lucia Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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Cosimo Durante Department of Internal Medicine and Medical Specialties, ‘Sapienza’ University of Rome, Rome, Italy

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features but benign cytology) or presumably benign (nodules with no suspicious ultrasound features) and managed with active surveillance as long as there was no evidence of malignancy. The images had been acquired in our thyroid cancer unit at the time of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0336
Volume/Issue:
Volume 7: Issue 1
Open access
Katerina Saltiki Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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Elli Anagnostou Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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George Simeakis Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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Sofia Kouki Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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Anastasia Angelopoulou Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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Leda Sarika Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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Alexandra Papathoma Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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Maria Alevizaki Endocrine Unit, Department of Medical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece

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). Interestingly, a higher percentage of RET exon-8 fMTC patients carried a second malignancy either at diagnosis or at follow-up (25.5% vs 6.3%, P  = 0.009, Pearson’s χ 2 ): of the RET exon 8 carriers, 9/51 (17.6%) had papillary thyroid cancer (PTC) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0147
Volume/Issue:
Volume 6: Issue 8
Open access
Yun Hu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China
Department of Immunology, Nanjing Medical University, Jiangsu, China

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Na Li Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Peng Jiang Department of Thyroid and Breast Surgery, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Liang Cheng Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Bo Ding Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Xiao-Mei Liu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Ke He Department of Endocrinology, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu, China

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Yun-Qing Zhu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Bing-li Liu Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Xin Cao Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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Hong Zhou Department of Immunology, Nanjing Medical University, Jiangsu, China

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Xiao-Ming Mao Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China

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relationship between thyroid nodule and thyroid cancer ( 3 , 4 ). Thyroid nodules are usually accompanied by an increase in thyroglobulin (Tg) ( 5 , 6 ) and autoimmune thyroid diseases (AITDs), especially Hashimoto’s thyroiditis (HT) ( 7 , 8 ). Interestingly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0545
Volume/Issue:
Volume 8: Issue 4
Open access
David C Llewellyn Department of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Rajaventhan Srirajaskanthan Neuroendocrine Tumour Unit, Kings Health Partners ENETS Centre of Excellence, Denmark Hill, London, UK
Faculty of Life Sciences and Medicine, Kings College London, London, UK

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Royce P Vincent Faculty of Life Sciences and Medicine, Kings College London, London, UK
Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK

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Catherine Guy Department of Cellular Pathology, Royal Sussex County Hospital, Eastern Road, Brighton, UK

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Eftychia E Drakou Department of Clinical Oncology, Guy’s Cancer Centre – Guy’s and St Thomas’ NHS Foundation Trust, Great Maze Pond, London, UK

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Simon J B Aylwin Department of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
Neuroendocrine Tumour Unit, Kings Health Partners ENETS Centre of Excellence, Denmark Hill, London, UK

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Ashley B Grossman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Barts and the London School of Medicine, Centre for Endocrinology, William Harvey Institute, London, UK
Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK

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John K Ramage Neuroendocrine Tumour Unit, Kings Health Partners ENETS Centre of Excellence, Denmark Hill, London, UK
Faculty of Life Sciences and Medicine, Kings College London, London, UK

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Georgios K Dimitriadis Department of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
Faculty of Life Sciences and Medicine, School of Life Course Sciences, Obesity Immunometabolism and Diabetes Group, King’s College London, London, UK

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left confluence of spongiform thyroid nodules, with hypoechoic halos (U2). No cervical lymphadenopathy. Following discussion in the thyroid cancer multi-disciplinary team meeting, her left thyroid confluence was upgraded to U4 using British

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0071
Volume/Issue:
Volume 10: Issue 4
Open access
Irfan Vardarli 5th Medical Department, Division of Endocrinology and Diabetes, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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Susanne Tan Department of Endocrinology, Diabetes and Metabolism, Clinical Chemistry – Division of Laboratory Research Endocrine Tumor Center at WTZ/Comprehensive Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Rainer Görges Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Bernhard K Krämer 5th Medical Department, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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Ken Herrmann Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Christoph Brochhausen Institue of Pathology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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value, and low specificity, a rule-out test for thyroid cancer, with ‘benign’ or ‘suspicious’ test results ( 8 ); (ii) ThyroSeq v2 (ThyroSeq; University of Pittsburgh Medical Center, Pittsburgh, PA, USA and Sonic Healthcare, Austin, TX, USA), released in

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Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0170
Volume/Issue:
Volume 13: Issue 7
Open access
Carina Hasenoehrl Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Gert Schwach Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Nassim Ghaffari-Tabrizi-Wizsy Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
SFL Chicken CAM Lab, Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria

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Robert Fuchs Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Nadine Kretschmer Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria

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Rudolf Bauer Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria

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Roswitha Pfragner Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Introduction Medullary thyroid carcinomas (MTC) arise from the parafollicular C-cells of the thyroid and account for 5–10% of all thyroid cancers ( 1 , 2 ). MTCs are calcitonin-producing tumors that occur sporadically in 70–80% of the cases

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0105
Volume/Issue:
Volume 6: Issue 2
Open access