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Kinnaree Sorapipatcharoen Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Thipwimol Tim-Aroon Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Pat Mahachoklertwattana Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Wasun Chantratita Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Nareenart Iemwimangsa Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Insee Sensorn Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Bhakbhoom Panthan Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Poramate Jiaranai Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Saisuda Noojarern Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Patcharin Khlairit Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Sarunyu Pongratanakul Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Chittiwat Suprasongsin Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Manassawee Korwutthikulrangsri Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Chutintorn Sriphrapradang Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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Preamrudee Poomthavorn Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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related to TD were found in TSHR gene. Four TSHR variants in 5 patients were detected. Of these 5 patients, 4 had either homozygous or compound heterozygous variants and one patient with subclinical hypothyroidism had heterozygous variant. Four

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0411
Volume/Issue:
Volume 9: Issue 11
Open access
Nannan Bian Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Xiaomeng Sun Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Biao Zhou Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

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Lin Zhang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Qiu Wang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Yu An Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Xiaohui Li Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Yinhui Li Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Jia Liu Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Hua Meng Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

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Guang Wang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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, IL-6 and TNF-α, are elevated in subclinical hypothyroidism patients ( 27 ), which could be reversed by bariatric surgery ( 19 , 20 ). In the study by Shen Qu et al. , the results revealed a correlation between the decrease in TSH and decrease in CRP

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0360
Volume/Issue:
Volume 10: Issue 10
Open access
Ruth Percik Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel

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Sherwin Criseno Department of Endocrinology, University Hospital Birmingham, Birmingham, UK

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Safwaan Adam Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK

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Kate Young Royal Marsden Hospital, London, UK

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Daniel L Morganstein Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK

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such as sub-clinical hypothyroidism. There are also implications for trial protocols, as endocrinopathies already present an exception, where current guidelines support the continuation of ICPIs, having initiated hormone replacement therapy, regardless

Article Type:
Review Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0513
Volume/Issue:
Volume 12: Issue 5
Open access
Selma Flora Nordqvist Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Victor Brun Boesen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Per Karkov Cramon Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

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Torquil Watt Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Herlev Gentofte Hospital, Copenhagen, Denmark

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Mogens Groenvold Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark

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Jakob Bue Bjorner Department of Public Health, University of Copenhagen, Copenhagen, Denmark
National Research Centre for the Working Environment, Copenhagen, Denmark
QualityMetric Incorporated, LLC, Johnston, Rhode Island, USA

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Thyroid hormone therapy for older adults with subclinical hypothyroidism . New England Journal of Medicine 2017 376 2534 – 2544 . ( https://doi.org/10.1056/NEJMoa1603825 ) 23 Watt T Thyroid-specific patient-reported outcome measure (ThyPRO

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0026
Volume/Issue:
Volume 10: Issue 3
Open access
Guillem Cuatrecasas Endocrinology Department, Hospital Quiron-Teknon, CPEN S.L., Barcelona, Spain
Universitat Oberta Catalunya (UOC), Barcelona, Spain

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Hatice Kumru Institut Guttmann, Institut Universitari de Neurorehabilitació Adscrit a la UAB, Barcelona, Spain
Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain

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M Josep Coves Endocrinology Department, Hospital Quiron-Teknon, CPEN S.L., Barcelona, Spain

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Joan Vidal Institut Guttmann, Institut Universitari de Neurorehabilitació Adscrit a la UAB, Barcelona, Spain
Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain

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perception and electrical pain perception threshold To investigate subclinical differences, we performed a sensory responsiveness quantification using electrical perception threshold (EPT) and EPPT at baseline (T0), T1, T3 and T6 (1, 3, 6 months). They were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0296
Volume/Issue:
Volume 7: Issue 10
Open access
Maria Giannakou Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece

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Katerina Saltiki Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece
Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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Emily Mantzou Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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Eleni Loukari Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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Georgios Philippou Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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Konstantinos Terzidis Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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Charalampos Stavrianos Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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Miltiades Kyprianou Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece

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Theodora Psaltopoulou Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National Kapodistrian University, Athens, Greece

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Kalliopi Karatzi Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece

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Maria Alevizaki Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece
Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece

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used varied, all studies reported increased oxidative stress levels ( 20 , 21 , 22 , 23 , 24 , 25 , 26 ). Moreover, high oxidative stress was present irrespective of the thyroid functional status – euthyroidism ( 20 , 21 , 22 ), subclinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0272
Volume/Issue:
Volume 7: Issue 9
Open access
Cornelia Then Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany

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Holger Then Freie Waldorfschule Augsburg, Augsburg, Germany

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Andreas Lechner Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany
German Center for Diabetes Research (DZD), München-Neuherberg, Germany

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Cornelia Huth German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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Christa Meisinger Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
Chair of Epidemiology at UNIKAT Augsburg, Ludwig-Maximilians-Universität München, Munich, Germany

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Margit Heier Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
KORA Study Center, University Hospital Augsburg, Augsburg, Germany

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Annette Peters German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

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Wolfgang Koenig DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
Deutsches Herzzentrum München, Technische Universität München, Munich, Germany

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Wolfgang Rathmann Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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Christian Herder German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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Michael Roden German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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Jürgen Scherberich Klinikum München-Harlaching, Teaching Hospital of the Ludwig-Maximilians-Universität, Munich, Germany

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Jochen Seissler Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany

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the metabolic syndrome and its components, indicating that chronic subclinical inflammation as assessed by hsCRP is not the only factor explaining the interplay of the metabolic syndrome and sUmod. Only the association of sUmod with elevated waist

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0352
Volume/Issue:
Volume 8: Issue 10
Open access
Min Li Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

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Ying Chen Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

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Jingjing Jiang Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

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Yan Lu Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

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Zhiyi Song Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Shengjie Zhang CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, China

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Chao Sun CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, China

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Hao Ying CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, China

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Xiaofang Fan Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China

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Yuping Song Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China

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Jialin Yang Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China

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Lin Zhao Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

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circulating Nrg4 levels were negatively correlated with serum TC levels. Consistently, Jiang et al . reported that lower circulating Nrg4 concentrations are associated with subclinical atherosclerosis in obese adults, as shown by increased carotid intima

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0175
Volume/Issue:
Volume 8: Issue 6
Open access
Stefan Riedl Division of Pediatric Pulmology, Allergology and Endocrinology, Department of Pediatrics, Medical University of Vienna, Vienna, Austria
Department of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, Vienna, Austria

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Friedrich-Wilhelm Röhl Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Germany

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Walter Bonfig Department of Pediatrics, Klinikum Wels-Grieskirchen, Wels, Austria

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Jürgen Brämswig Department of Pediatrics, Pediatric Endocrinology, Westfälische Wilhelmsuniversität Münster, Münster, Germany

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Annette Richter-Unruh Department of Pediatrics, Pediatric Endocrinology, Westfälische Wilhelmsuniversität Münster, Münster, Germany

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Susanne Fricke-Otto Department of Pediatrics, Pediatric Endocrinology, Helios Klinikum Krefeld, Krefeld, Germany

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Markus Bettendorf Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany

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Felix Riepe Pediatric Endocrinology, Kronshagen, Kiel, Germany

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Gernot Kriegshäuser Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria

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Eckhard Schönau Department of Pediatrics, Pediatric Endocrinology, Universität zu Köln, Cologne, Germany

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Gertrud Even Department of Pediatrics, Pediatric Endocrinology, Universität zu Köln, Cologne, Germany

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Berthold Hauffa Department of Pediatric Endocrinology, University of Duisburg-Essen, Essen, Germany

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Helmuth-Günther Dörr Department of Pediatrics, Pediatric Endocrinology, Friedrich Alexander Universität Erlangen, Erlangen, Germany

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Reinhard W Holl Institute of Epidemiology and Medical Biometry (ZIBMT), University of Ulm, Ulm, Germany

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Klaus Mohnike Department of Pediatrics, Pediatric Endocrinology, Otto von Guericke Universität Magdeburg, Magdeburg, Germany

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the AQUAPE CAH Study Group
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production, which may be sufficient for aldosterone homeostasis, leads to simple virilizing (SV) or, less symptomatic, nonclassical CAH phenotypes (NC CAH). However, subclinical or clinical mineralocorticoid deficiency, particularly in small infants, leads to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0281
Volume/Issue:
Volume 8: Issue 2
Open access
Veronica Kieffer
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Kate Davies University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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Christine Gibson University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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Morag Middleton University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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Jean Munday University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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Shashana Shalet University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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Lisa Shepherd University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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Phillip Yeoh University Hospitals of Leicester NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Central Manchester University Hospitals NHS Foundation Trust, NHS Grampian, Portsmouth Hospitals NHS Trust, Salford Royal Hospitals Foundation Trust, Heart of England NHS Foundation Trust, The London Clinic, Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK

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medication • Recognises thyroid function results which show subclinical disease and discusses these patients individually with senior staff • Arranges appropriate investigations and is able to interpret the results before developing a clinical treatment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0134
Volume/Issue:
Volume 4: Issue 1
Open access