Monika Karczewska-Kupczewska
Monika Karczewska-Kupczewska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Agnieszka Nikołajuk
Agnieszka Nikołajuk
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
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Magdalena Stefanowicz
Magdalena Stefanowicz
Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Natalia Matulewicz
Natalia Matulewicz
Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Irina Kowalska
Irina Kowalska
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland
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Marek Strączkowski
Marek Strączkowski
Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
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had no clinical and laboratory signs of inflammation and had not taken anti-inflammatory drugs within the last 3 months. A standard oral glucose tolerance test (OGTT) was performed and all subjects had normal glucose tolerance according to World Health
Yali Cheng
Yali Cheng
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Qiaoying Lv
Qiaoying Lv
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Bingying Xie
Bingying Xie
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Bingyi Yang
Bingyi Yang
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Weiwei Shan
Weiwei Shan
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Chengcheng Ning
Chengcheng Ning
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Bing Li
Bing Li
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Liying Xie
Liying Xie
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Chao Gu
Chao Gu
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Xuezhen Luo
Xuezhen Luo
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Xiaojun Chen
Xiaojun Chen
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Qin Zhu
Qin Zhu
Department of Pathology, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, China
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) biosynthesis and estrogen receptor to increase the estrogen sensitivity in local endometrium. Mechanistically, chronic inflammation induced by insulin resistance might be the key modulator for estrogen activity ( 8 ). Studies demonstrated that increased IL6
Thorben Hoffmann
Thorben Hoffmann
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
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Yousef Ashraf Tawfik Morcos
Yousef Ashraf Tawfik Morcos
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Ruth Janoschek
Ruth Janoschek
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
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Eva-Maria Turnwald
Eva-Maria Turnwald
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
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Antje Gerken
Antje Gerken
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Annette Müller
Annette Müller
Center for Pediatric Pathology at the University Hospital Cologne, Cologne, Germany
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Gerhard Sengle
Gerhard Sengle
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany
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Jörg Dötsch
Jörg Dötsch
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
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Sarah Appel
Sarah Appel
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
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Eva Hucklenbruch-Rother
Eva Hucklenbruch-Rother
Department of Pediatrics, and Adolescent Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany
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( 27 ). Furthermore, we detected asprosin in decidual cells in the maternal side of the placenta, which are also known to play a role in immune regulation ( 28 ). Since asprosin seems to play a role in inflammation in other tissues ( 29 , 30 ), it may
Legh Wilkinson
Legh Wilkinson
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa
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Nicolette J D Verhoog
Nicolette J D Verhoog
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa
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Ann Louw
Ann Louw
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa
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Introduction Due to the interrelatedness of the stress and inflammatory responses, chronic persistent inflammation may be considered both a cause and a consequence of a prolonged disruption of the central HPA axis, a systemic signalling
Xue-Jiao Yang
Xue-Jiao Yang
School of Public Health, Medical College of Soochow University, Suzhou, China
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Le-Yang Zhang
Le-Yang Zhang
Medical College of Soochow University, Suzhou, China
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Qing-Hua Ma
Qing-Hua Ma
The 3rd People’s Hospital of Xiangcheng District, Suzhou, China
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Hong-Peng Sun
Hong-Peng Sun
School of Public Health, Medical College of Soochow University, Suzhou, China
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Yong Xu
Yong Xu
School of Public Health, Medical College of Soochow University, Suzhou, China
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Xing Chen
Xing Chen
Department of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China
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Chen-Wei Pan
Chen-Wei Pan
School of Public Health, Medical College of Soochow University, Suzhou, China
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. Platelet parameters may be promising biomarkers for predicting early signs of metabolic abnormalities. The pathophysiology of MetS includes inflammation, insulin resistance, oxidative stress and endothelial dysfunction and triggers platelet hyperactivity
Selina Mäkinen
Selina Mäkinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Yen H Nguyen
Yen H Nguyen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Paulina Skrobuk
Paulina Skrobuk
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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Heikki A Koistinen
Heikki A Koistinen
Minerva Foundation Institute for Medical Research, Helsinki, Finland
University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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University of Helsinki, Department of Medicine, and Abdominal Center, Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
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beneficial effects of oleate on palmitate-induced ER stress, inflammation and insulin resistance ( 31 ). These data suggest that the protective effects of oleate may be mediated via AMPK activation. In agreement, we observed increased AMPK phosphorylation in
Qi Che
Qi Che
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Xirong Xiao
Xirong Xiao
Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
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Jun Xu
Jun Xu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Miao Liu
Miao Liu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Yongning Lu
Yongning Lu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Suying Liu
Suying Liu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Xi Dong
Xi Dong
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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are important contributors to worse clinical outcomes of malignant tumors ( 8 ). The pro-tumorigenic behaviors of IL-6 cytokine family members are initiated by cancer cell activities or indirect effects, such as regulation of inflammation
Ann-Kristin Picke
Ann-Kristin Picke
Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany
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Graeme Campbell
Graeme Campbell
Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany
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Nicola Napoli
Nicola Napoli
Diabetes and Bone Network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy
Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA
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Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA
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Lorenz C Hofbauer
Lorenz C Hofbauer
Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Martina Rauner
Martina Rauner
Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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T2DM leading to bone marrow adiposity and increased expression of cytokines and chemokines as well as to an elevated amount of free unsaturated fatty acids. (3) This results in increased inflammation leading to accumulation of pro-inflammatory M1
E R Polina
E R Polina
Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
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F M Oliveira
F M Oliveira
Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
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R C Sbruzzi
R C Sbruzzi
Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
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D Crispim
D Crispim
Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
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L H Canani
L H Canani
Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
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Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
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K G Santos
K G Santos
Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
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Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
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biochemical pathways that induce inflammation and oxidative stress, thus leading to blood-retinal barrier breakdown, pericyte loss, neuronal death and angiogenesis ( 3 ). miRNAs are small ncRNA molecules that regulate gene expression mainly through the
S Westra
S Westra
Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands
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Y H M Krul-Poel
Y H M Krul-Poel
Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands
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H J van Wijland
H J van Wijland
Department of General Practice, DIAZON, Alkmaar, the Netherlands
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M M ter Wee
M M ter Wee
Department of Epidemiology and Biostatistics, VU Medical Centre, Amsterdam, the Netherlands
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F Stam
F Stam
Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands
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P Lips
P Lips
Department of Internal Medicine, Endocrine Section, VU Medical Centre, Amsterdam, the Netherlands
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F Pouwer
F Pouwer
Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands
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S Simsek
S Simsek
Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands
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oxidative stress, vitamin D may influence low-grade systemic inflammation, which is linked to both depressive symptoms and insulin resistance ( 20 , 21 ). Another possible link between vitamin D status and depressive symptoms is an elevated parathyroid
