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Monia Cito Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Silvia Pellegrini Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Lorenzo Piemonti Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy

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Valeria Sordi Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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-01) were encapsulated into an immune-protecting medical device (named Encaptra drug delivery system) and transplanted in a small cohort of T1D patients. This trial aims to evaluate safety, long-term tolerability and efficacy of this system and the

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T P McVeigh Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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R J Mulligan Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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U M McVeigh Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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P W Owens Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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N Miller Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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M Bell Department of Endocrinology, School of Medicine, NUI Galway, Galway, Ireland

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F Sebag Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France

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C Guerin Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France

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D S Quill Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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J B Weidhaas David Geffen School of Medicine, University of California, Los Angeles, USA

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M J Kerin Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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A J Lowery Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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includes two closely related but genetically distinct microRNAs, miR-146a and miR-146b, differing only at two nucleotides in the 3′ region of the mature sequences ( 17 ). These miRNAs are critical in a number of immune and inflammatory response pathways

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Barbara J Boucher Blizard Institute, Barts & The London school of Medicine & Dentistry, Queen Mary University of London, London, UK

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associated with obesity, immunity, the rates of many infections, cancers (e.g. breast and colorectal), and cancer mortality, with chronic disorders such as insulin resistance, metabolic syndrome (Syndrome X), type 2 diabetes (T2DM), acute cardiovascular

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Masatada Watanabe Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan

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Shuji Ohno Division of Research for Pharmacy Students Education, Hoshi University, Shinagawa, Tokyo, Japan

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Hiroshi Wachi Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan

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contraction of peripheral blood vessels, whereas an increase in the circulating glucocorticoid concentration suppresses the immune system. Consequently, long-term stress could make the body vulnerable to atopic dermatitis, in other words, could result in an

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June Young Choi Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea

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Jin Wook Yi Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Jun Hyup Lee Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Ra-Yeong Song Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Hyeongwon Yu Department of Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea

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Hyungju Kwon Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Young Jun Chai Department of Surgery, Seoul National University Boramae Hospital, Seoul, Korea

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Su-jin Kim Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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Kyu Eun Lee Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea

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article) shows the pathways that are significantly enriched by 545 upregulated DEGs in high VDR group, using DAVID. Cellular interaction, autoimmune thyroid disease, immune receptor-related signal pathways, cancer-related chemokine signaling and the JAK

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Kusum Lata Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Pinaki Dutta Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Subbiah Sridhar Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Minakshi Rohilla Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Anand Srinivasan Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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G R V Prashad Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Viral N Shah Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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Anil Bhansali Departments of Obstetrics and Gynecology, Endocrinology, Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

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effect on granulosa cells, luteal cells and oocyte maturation (8) . Euthyroid women with thyroid autoimmunity are twice as likely to experience spontaneous miscarriages (9) . This probably represents a generalised activation of the immune system, or an

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Xi Zhang Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China

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Xiurong Shen Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Graduate School, Wannan Medical College, Wuhu, Anhui, People’s Republic of China

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Wan Zhou Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Mengyun Xu Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Yan Xing Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Jianping Weng Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Shandong Ye Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Suowen Xu Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Zhi Zhang Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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Wei Wang Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China
Institute of Endocrine and Metabolic Diseases, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China

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chromatography with an HbA1c radiometer (Bio-Rad Laboratory Inc.). Urinary albumin was assayed using immune turbidimetry kits purchased from Northern Biotechnology Research Institute (Beijing, China). Urine albumin creatinine ratio (UACR) was calculated as the

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Qi Che Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Xirong Xiao Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

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Jun Xu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Miao Liu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Yongning Lu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Suying Liu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Xi Dong Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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tumor tissues ( 6 ). IL-6 belongs to the main member of the IL-6 cytokine family and regulates multitudinous functions related to biological metabolism and immunity ( 7 ). Abnormal IL-6 cytokine expression and its aberrant downstream signaling activation

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Clara Lundetoft Clausen Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark

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Trine Holm Johannsen Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

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Niels Erik Skakkebæk Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

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Hanne Frederiksen Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Thomas Benfield Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Vlachogiannis NI Paraskevis D Kaltsas GA Chrousos GP , et al. Alterations in cortisol and interleukin-6 secretion in patients with COVID-19 suggestive of neuroendocrine-immune adaptations. Endocrine 2022 75 317 – 327 . ( https://doi.org/10.1007/s12020

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Charlotte Höybye Patient Area Endocrinology and Nephrology, Infection and Inflammation Theme, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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Laia Faseh Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

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Christos Himonakos Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
Department of Medicine, Karlstad Hospital, Karlstad, Sweden

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Tomasz Pielak NUTOPI Sp. z o. o., Poznan, Poland

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Jesper Eugen-Olsen Clinical Research Centre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

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plasminogen activator receptor (uPAR) is a membrane bound receptor mainly expressed on immune cells ( 15 , 16 ). uPAR is involved in several physiological and pathological pathways including cell signalling, cell migration, immune response, angiogenesis and

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