Dorte Glintborg
Dorte Glintborg
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Katrine Hass Rubin
Katrine Hass Rubin
OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
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Mads Nybo
Mads Nybo
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
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Bo Abrahamsen
Bo Abrahamsen
OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Marianne Andersen
Marianne Andersen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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prospective development of type 2 diabetes, incident fractures, and cardiovascular disease ( 15 , 16 , 17 ) in the study cohort. The authors followed all of the STROBE guidelines in manuscript preparation. Assays in PCOS OUH Blood samples were
Pinaki Dutta
Pinaki Dutta
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Bhuvanesh Mahendran
Bhuvanesh Mahendran
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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K Shrinivas Reddy
K Shrinivas Reddy
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Jasmina Ahluwalia
Jasmina Ahluwalia
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Kim Vaiphei
Kim Vaiphei
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Rakesh K Kochhar
Rakesh K Kochhar
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Prakamya Gupta
Prakamya Gupta
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Anand Srinivasan
Anand Srinivasan
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Mahesh Prakash
Mahesh Prakash
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Kanchan Kumar Mukherjee
Kanchan Kumar Mukherjee
Department of Endocrinology, Internal Medicine, Cardiology, Hematology, Histopathology, Gastroenterology, Neurosurgery, Pharmacology, Radiodiagnosis, 4th Floor, F Block, Post Graduate Institute of Medical Education and Research, Nehru Hospital, Chandigarh 160012, India
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Viral N Shah
Viral N Shah
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Girish Parthan
Girish Parthan
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Anil Bhansali
Anil Bhansali
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acromegaly patients with GHD previously. Despite higher GH and IGF1 levels in patients with acromegaly, they are at increased risk for low BMD. Paradoxically, fracture risk is increased in acromegaly patients even with increased BMD or BMC. So the improvement
Paraskevi Kazakou
Paraskevi Kazakou
Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Stavroula A Paschou
Stavroula A Paschou
Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Theodora Psaltopoulou
Theodora Psaltopoulou
Unit of Hematology and Oncology, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Maria Gavriatopoulou
Maria Gavriatopoulou
Unit of Hematology and Oncology, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Eleni Korompoki
Eleni Korompoki
Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Katerina Stefanaki
Katerina Stefanaki
Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Fotini Kanouta
Fotini Kanouta
Department of Endocrinology, Alexandra Hospital, Athens, Greece
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Georgia N Kassi
Georgia N Kassi
Department of Endocrinology, Alexandra Hospital, Athens, Greece
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Meletios-Athanasios Dimopoulos
Meletios-Athanasios Dimopoulos
Unit of Hematology and Oncology, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Asimina Mitrakou
Asimina Mitrakou
Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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recovery in patients with vitamin D deficiency and hypocalcemia (124, 125, 126, 127, 128) Vertebral fractures (126) Vitamin D deficiency (123) Increased PTH (123) Home isolation and low sun exposure during lockdowns (123) ACE, angiotensin
Barbara J Boucher
Barbara J Boucher
Blizard Institute, Barts & The London school of Medicine & Dentistry, Queen Mary University of London, London, UK
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i6583. ( https://doi.org/10.1136/bmj.i6583 ) 62 Sanders KM , Stuart AL , Williamson EJ , Simpson JA , Kotowicz MA , Young D & Nicholson GC . Annual high-dose oral vitamin D and falls and fractures in older women: a randomized
Florian Schederecker
Florian Schederecker
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
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Alexander Cecil
Alexander Cecil
Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
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Cornelia Prehn
Cornelia Prehn
Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
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Jana Nano
Jana Nano
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
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Wolfgang Koenig
Wolfgang Koenig
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
Deutsches Herzzentrum München, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
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Deutsches Herzzentrum München, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
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Jerzy Adamski
Jerzy Adamski
Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Tanja Zeller
Tanja Zeller
Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany
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German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany
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Annette Peters
Annette Peters
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Munich, Munich, Germany
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German Centre for Cardiovascular Research (DZHK), Partner Site Munich, Munich, Germany
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Barbara Thorand
Barbara Thorand
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
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( 49 , 50 ). Unfortunately, BMI (which used in our analysis) is a relatively crude measure of body composition. Additionally, higher levels of SHBG are associated with increased frailty and fracture ( 11 , 51 ). Direct effect of SHBG – as
Thabiso R P Mofokeng
Thabiso R P Mofokeng
Department of Medicine, University of the Free State, Bloemfontein, South Africa
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Salem A Beshyah
Salem A Beshyah
Department of Medicine, Dubai Medical College, Duabi, United Arab Emirates
Department of Endocrinology, Mediclinic Airport Road Hospital, Abu Dhabi, United Arab Emirates
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Department of Endocrinology, Mediclinic Airport Road Hospital, Abu Dhabi, United Arab Emirates
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Fazleh Mahomed
Fazleh Mahomed
Department of Medicine, University of the Free State, Bloemfontein, South Africa
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Kwazi C Z Ndlovu
Kwazi C Z Ndlovu
Department of Medicine, University of the Free State, Bloemfontein, South Africa
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Ian L Ross
Ian L Ross
Division of Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa
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prednisolone and dexamethasone has been associated with undesirable side-effects such as wakefulness, nocturia, ( 38 ), bone mass reduction ( 39 , 40 , 41 ), hip fractures ( 42 ), adverse metabolic health ( 43 , 44 ), and increased mortality ( 45
Amarjit Saini
Amarjit Saini
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Linda Björkhem-Bergman
Linda Björkhem-Bergman
Division of Clinical Geriatrics, Departments of Neurobiology, Care Sciences and Neurobiology, Karolinska Institutet, Stockholm, Sweden
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Johan Boström
Johan Boström
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Mats Lilja
Mats Lilja
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Michael Melin
Michael Melin
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
Unit of Cardiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
Unit of Cardiology, Karolinska University Hospital, Stockholm, Sweden
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Karl Olsson
Karl Olsson
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Lena Ekström
Lena Ekström
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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Peter Bergman
Peter Bergman
Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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Mikael Altun
Mikael Altun
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Eric Rullman
Eric Rullman
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
Unit of Cardiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
Unit of Cardiology, Karolinska University Hospital, Stockholm, Sweden
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Thomas Gustafsson
Thomas Gustafsson
Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden
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/L) may also lead to muscle weakness, falls and fragility fractures in older people ( 1 ). These are highly significant public health issues in terms of morbidity, quality of life and costs to health services. vitamin D status has been proposed as an
Panagiotis Anagnostis
Panagiotis Anagnostis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Irene Lambrinoudaki
Irene Lambrinoudaki
2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
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John C Stevenson
John C Stevenson
National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
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Dimitrios G Goulis
Dimitrios G Goulis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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.58–2.82) and, respectively. However, MHT was associated with a reduced risk of colorectal cancer (HR 0.63, 95% CI 0.43–0.92) hip (HR 0.66, 95% CI 0.45–0.98) and total fractures (HR 0.76, 95% CI 0.69–0.85) ( 42 ). Notably, when the final results of WHI-1 were
Fabienne A U Fox
Fabienne A U Fox
Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
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Lennart Koch
Lennart Koch
Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
University for Health Sciences, Medical Informatics and Technology (UMIT TIROL), Tirol, Austria
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University for Health Sciences, Medical Informatics and Technology (UMIT TIROL), Tirol, Austria
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Monique M B Breteler
Monique M B Breteler
Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany
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Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany
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N Ahmad Aziz
N Ahmad Aziz
Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany
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Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany
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= 2), technical/acquisition failure ( n = 141) or ineligibility ( n = 223). Participants were deemed ineligible if they had an amputation or a fracture of the tested arm within the last month. They were also excluded from participation if they were
Barbara J Boucher
Barbara J Boucher
The Blizard Institute, Queen Mary University of London, London, UK
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supplementation for incident fractures in those over 60 years. An accompanying comment states that the VITAL study showed ‘no important health benefits from supplementation in the general population of older adults’, even ‘when initially deficient’ ( 91 , 92
