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, 33, 34) . Both the increase in mitochondrial content and oxidative capacity (35) , as well as the development of IR (36) , occur at around 3–4 weeks of high-fat feeding. Furthermore, in a recent comparison of mouse strain, our group showed that this
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observations demonstrated that the activation of the Nrf2/GPX4 axis could protect β cells from ferroptosis. Collectively, the occurrence and development of diabetes may be tightly associated with ferroptosis. Overview of ferroptosis Ferroptosis is an
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complicated and ambiguous pathogenesis. Many risk factors have been identified, such as obesity, genetics and early childhood growth patterns ( 4 , 5 ). Data from many studies suggest that genetics is very important in the development of PCOS. A Dutch twin
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information for precision medicine. The classification of ever-increasing patients with obesity is a prerequisite for the precision intervention of this condition ( 20 ). Clinically, the primary unhealthy state related to obesity is the development of IGT
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Section of Biostatistics, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
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reach the fetus. Successful intrauterine development of the human fetus is highly dependent on hormonal regulation, and disturbance of hormones during pregnancy might therefore have dramatic consequences for the development of the unborn child. In
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Endocrine, Cardiovascular & Metabolic Research, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS/UP), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Hospital S. João, Porto, Portugal
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the main reasons associated to adrenal tumor cells resistance to chemotherapy is compromised apoptosis signaling, a fact that deregulates the balance between cell death and survival, thus facilitating tumor development, invasion and resistance to
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, interleukin 6 (IL6), plasminogen activator inhibitor type 1, and resistin are among the adipocytokines secreted from the WAT. In obese humans, these adipocytokines play a role in the development of a cluster of metabolic abnormalities characterized by central
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insulin resistance (7) . In some studies, under-nutrition in utero has been associated with increased catch-up growth in childhood, increased relative percent body fat, and obesity (8, 9, 10, 11) . It is known that the development of type 2 diabetes
Université Côte d'Azur, INSERM, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France
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NK92 lysis To provide further evidence for the role of PGC1A in tumor development, we explore the possible relationship between PGC1A with tumor aggressiveness of BC cells. PGC1A gene expression was assessed in two basal cell lines with a high
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levels and HbA1c ( 11 , 13 ). Hypoandrogenism in men and hyperandrogenism in women (e.g., the polycystic ovary syndrome) have been linked to insulin resistance and the metabolic syndrome ( 13 , 14 ). In one report, SHBG levels predicted the development