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Johan Verhelst Department of Endocrinology, ZNA Middelheim Hospital, Antwerp, Belgium

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Anders F Mattsson Pfizer Endocrine Care, Pfizer Health AB, Sollentuna, Sweden

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Cecilia Camacho-Hübner Pfizer Endocrine Care, Pfizer, Inc., New York, New York, USA

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Anton Luger Division of Endocrinology and Metabolism, Medical University and General Hospital, Vienna, Austria

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Roger Abs Antwerp Centre for Endocrinology, Antwerp, Belgium

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>100 mg/dL (5.6 mmol/L) or type 2 diabetes (defined by a random or 2 h OGTT glucose ≥200 mg/dL (11.1 mmol/L); a HbA1c ≥6.4% or the use of anti-diabetic drugs ( 20 ). The MetS score, ranging between 0 and 5, corresponds to the sum of the abnormal MetS

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Anru Wang Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Xueqin Yan Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China

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Cai Zhang Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caiqi Du Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Wenjun Long Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Di Zhan Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiaoping Luo Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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fasting glucose and insulin levels were increased in FGF1−/− mice fed with an HFD ( 22 ). Wang et al . reported that serum FGF1 significantly correlated with fasting glucose, 2-h post-OGTT glucose and HOMA-β ( 8 ). In addition, HbA1c were the independent

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Rongpeng Gong Medical College of Qinghai University, Xining, People’s Republic of China

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Yuanyuan Liu Medical College of Qinghai University, Xining, People’s Republic of China

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Gang Luo Medical College of Qinghai University, Xining, People’s Republic of China

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Jiahui Yin College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China

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Zuomiao Xiao Department of Clinical Laboratory, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, China

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Tianyang Hu Precision Medicine Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

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blood glucose, or 2 h-OGTT test ≥ 11.0 mmol/L, was taking diabetes-related drugs. BMI was calculated based on height and weight, and its formula is BMI = weight/height-squared (kg/m 2 ). Laboratory data The collection of laboratory data was

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Sirazum Choudhury Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Tricia Tan Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Katharine Lazarus Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Karim Meeran Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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patients. In addition to this, the participants with prediabetes also showed reductions in fasting insulin, insulin secretion over 2 h in response to an oral glucose tolerance test (OGTT) and an increase in both insulin sensitivity and HDL. No improvements

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Yaqian Mao Shengli Clinical Medical College of Fujian Medical University, Fujian, China
Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Lizhen Xu Shengli Clinical Medical College of Fujian Medical University, Fujian, China

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Ting Xue Shengli Clinical Medical College of Fujian Medical University, Fujian, China

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Jixing Liang Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Wei Lin Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Junping Wen Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Huibin Huang Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Liantao Li Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Gang Chen Shengli Clinical Medical College of Fujian Medical University, Fujian, China
Department of Endocrinology, Fujian Provincial Hospital, Fujian, China
Fujian Provincial Key Laboratory of Medical Analysis, Fujian Academy of Medical, Fujian, China

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), triglycerides (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and uric acid (UA). All subjects underwent oral glucose tolerance testing (OGTT), and fasting plasma glucose (FPG

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Gaëtan Prévost Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Marie Picot Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Marie-Anne Le Solliec Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Arnaud Arabo Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hind Berrahmoune Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Mouna El Mehdi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Saloua Cherifi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Alexandre Benani Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Emmanuelle Nédélec Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Françoise Gobet Department of Anatomopathophysiology, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Valéry Brunel Department of Biochemistry, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Jérôme Leprince Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hervé Lefebvre Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Youssef Anouar Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Nicolas Chartrel Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Committee instructions, and the study was approved by the Ethical Committee of Haute-Normandie (CCPPRB-HN; ( 26 )). The obese patients and the healthy volunteers underwent a 75-g oral glucose tolerance test (OGTT) after a 12-h fasting period. Plasma 26RFa

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Hui-qing Yuan Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Jia-xi Miao Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Jia-ping Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Su-xiang Zhu Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Feng Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Xiao-hua Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Chun-hua Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Chao Yu Department of Clinical Laboratory, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Dong-mei Zhang Medical Research Center, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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. ( https://doi.org/10.1210/clinem/dgab019 ) 4 Lund A Bagger JI Christensen M Grondahl M van Hall G Holst JJ Vilsboll T Knop FK . Higher endogenous glucose production during OGTT vs Isoglycemic intravenous glucose infusion . Journal of

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Cheryl M Isherwood Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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M Denise Robertson Section of Metabolic Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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Debra J Skene Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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Jonathan D Johnston Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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2014 111 10761 – 10766 . ( https://doi.org/10.1073/pnas.1402663111 ) 34 Manell H Staaf J Manukyan L Kristinsson H Cen J Stenlid R Ciba I Forslund A & Bergsten P . Altered plasma levels of glucagon, GLP-1 and glicentin during OGTT

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Sebastião Freitas de Medeiros Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil
Tropical Institute of Reproductive Medicine, Cuiabá, Mato Grosso, Brazil

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Márcia Marly Winck Yamamoto Tropical Institute of Reproductive Medicine, Cuiabá, Mato Grosso, Brazil

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Matheus Antônio Souto de Medeiros Tropical Institute of Reproductive Medicine, Cuiabá, Mato Grosso, Brazil

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Bruna Barcelo Barbosa Tropical Institute of Reproductive Medicine, Cuiabá, Mato Grosso, Brazil

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José Maria Soares Junior Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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Edmund Chada Baracat Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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P4 level was lower than 6.3 nmol/L ( 30 ). A glucose oxidase technique (Beckman Glucose Analyses, Fullerton, CA, USA) was used to measure fasting glucose. For the oral glucose tolerance test (OGTT), blood samples were collected at 0, 30, 60, 90, 120

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