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Amir Bashkin Department of Endocrinology, Galilee Medical Center, Nahariya, Israel
Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

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Eliran Yaakobi Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

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Marina Nodelman Department of Endocrinology, Galilee Medical Center, Nahariya, Israel
Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

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Ohad Ronen Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel
Department of Otolaryngology Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel

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hospitalization is usually the result of stress due to the acute illness that led to hospitalization or the effect of drug therapy. In rare cases, thyroid dysfunction may result from thyroid disease and without treatment may adversely affect hospitalization

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V Kenan Çelik Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey

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Sercan Kapancık Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey

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Turgut Kaçan Department of Medical Oncology, High Specialized Education and Research Hospital, Bursa, Turkey

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Selen Baloglu Kaçan Department of Internal Medicine, Afyonkarahisar State Hospital, Afyon, Turkey

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Serkan Kapancık Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey

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Hasan Kılıçgün Department of Nutrition and Dietetics, Health Science Faculty, University of Erzincan, Erzincan, Turkey

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depressive disorder (MDD) and stress ( 9 ). Intracellular and extracellular concentrations of polyamines are important in all these biological orientations. The amounts of polyamines are tightly regulated by the ornithine decarboxylase (ODC), a rate

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Stephen Ball Department of Endocrinology, Central Manchester University Hospitals Foundation Trust, Manchester Royal Infirmary, Manchester, UK

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Julian Barth Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Blood Sciences, Leeds, UK

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Miles Levy Department of Endocrinology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK

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the Society for Endocrinology Clinical Committee The Society for Endocrinology, 22 Apex Court, Woodlands, Bradley Stoke, Bristol, UK

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of development of hyponatraemia The intrinsic ability of the central nervous system to adapt to changing osmolar stress The range and degree of co-morbidities Severe symptoms are unlikely with serum sodium >130 mmol/L and alternative causes of

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Ermina Bach Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Niels Møller Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Jens Otto L Jørgensen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Mads Buhl The Neonatal Intensive Care Unit, Aarhus University Hospital, Aarhus, Denmark

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Holger Jon Møller Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

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are indirect, since LPS acts through a number of cytokines and also activates the hypothalamo-pituitary axis (HPA) and stimulates the release of stress hormones (e.g. cortisol) into the blood ( 21 , 22 , 23 ). Since CD163 is strongly expressed in

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Stig Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark

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Rats s.c. infusion (T4) Postnatal months 1–3 Altered morphology of hippocampal neurons and impaired ability to cope with stress Zhang et al. (22) 2010 Rats s.c. infusion (T4) Postnatal months 1–3 Aberrant organization of

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Chenmin Wei Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Department of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Zichen Zhang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Qi Fu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Yunqiang He Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Min Sun Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Introduction Various factors may be responsible for β cell dysfunction, including reduced β cell mass (due to de- or transdifferentiation into other cell type) and β cell exhaustion (related to endoplasmic reticulum (ER) and oxidative stress

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Shih-Rong Lin Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan

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Shih-Fen Chen Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

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Yu-Cih Yang Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

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Chung-Y Hsu Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

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Yu-Chih Shen Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
Department of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
School of Medicine, Tzu Chi University, Hualien, Taiwan

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therapy, a significant risk association has been observed. There are possible explanations that may account for the mechanisms underlying this observation. First, hyperthyroidism has been linked to increased oxidative stress and a deregulated

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Zeeshan Javed Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan

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Maria Papageorgiou Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Leigh A Madden School of Life Sciences, University of Hull, Hull, UK

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Alan S Rigby Hull York Medical School, University of Hull, Hull, UK

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Eric S Kilpatrick Department of Pathology, Sidra Medical and Research Center, Doha, Qatar

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Stephen L Atkin Royal College of Surgeons in Ireland, Al Sayh, Bahrain

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Thozhukat Sathyapalan Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

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, reactive oxygen species (ROS), lipopolysaccharides, thrombin and low shear stress. In turn, by facilitating the interactions of endothelial cells with immune cells, EMPs are involved in endothelial cell modifications, inflammation, coagulation and

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Thiago U Pantaleão Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Andrea C F Ferreira Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
NUMPEX, Pólo de Xerém, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Maria C S Santos Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Álvaro S P Figueiredo Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Ruy A N Louzada Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Doris Rosenthal Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Denise P Carvalho Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Vânia M Corrêa da Costa Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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activity. Increased oxidative stress was previously associated with the inhibition of D1 ( 26 ), but herein we did not detect any association between increased H 2 O 2 generation and D1 activity. In fact, we have shown that at the highest dose (250 µg/100

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Xiuhua Liao Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China

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Suqin Zhu Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

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Shumin Qiu Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

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Hua Cao Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

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Wenwen Jiang Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

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Huiling Xu Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

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Yan Sun Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

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Beihong Zheng Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
Fujian Maternal-Fetal Clinical Medicine Research Center, Fuzhou, China
Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou, China

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mitochondrial morphology, interorganelle Ca 2+ transport ( 12 , 13 ), lipid transportation, and participates in ER stress ( 14 ) and mitophagy. It is a key mediator of mitochondrial fusion, and its expression is decreased in PCOS patients ( 15 ). Mfn2 has been

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