Johan Verhelst
Johan Verhelst
Department of Endocrinology, ZNA Middelheim Hospital, Antwerp, Belgium
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Anders F Mattsson
Anders F Mattsson
Pfizer Endocrine Care, Pfizer Health AB, Sollentuna, Sweden
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Cecilia Camacho-Hübner
Cecilia Camacho-Hübner
Pfizer Endocrine Care, Pfizer, Inc., New York, New York, USA
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Anton Luger
Anton Luger
Division of Endocrinology and Metabolism, Medical University and General Hospital, Vienna, Austria
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Roger Abs
Roger Abs
Antwerp Centre for Endocrinology, Antwerp, Belgium
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Introduction It is now well-recognized that patients with adult-onset growth hormone deficiency (AO-GHD), apart from experiencing a poor quality of life (QoL), present with an increased risk of developing a metabolic syndrome (MetS) ( 1 , 2
Hamidreza Mani
Hamidreza Mani
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
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Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
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Yogini Chudasama
Yogini Chudasama
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Michelle Hadjiconstantinou
Michelle Hadjiconstantinou
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Danielle H Bodicoat
Danielle H Bodicoat
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Charlotte Edwardson
Charlotte Edwardson
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Biomedical Research Centre, Leicester and Loughborough, UK
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The Leicester Biomedical Research Centre, Leicester and Loughborough, UK
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Miles J Levy
Miles J Levy
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
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Laura J Gray
Laura J Gray
Department of Health Sciences, University of Leicester, Leicester, UK
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Janette Barnett
Janette Barnett
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
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Heather Daly
Heather Daly
Leicester Medical Group, Thurmaston Health Centre, Leicester, UK
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Trevor A Howlett
Trevor A Howlett
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
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Kamlesh Khunti
Kamlesh Khunti
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Melanie J Davies
Melanie J Davies
Diabetes Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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impairment, emotional impairment, emotions, vitality, pain and global health) ( 14 ). The composite score in SF12V2 was calculated using the approved software by the company (Quality.Metrics). Step-counts and other activity data were objectively measured by
João Castro-Teles
João Castro-Teles
Department of Biomedicine, Faculty of Medicine of the University of Porto, Porto, Portugal
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Bernardo Sousa-Pinto
Bernardo Sousa-Pinto
MEDCIDS, Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
CINTESIS, Center for Health Technology and Services Research, University of Porto, Porto, Portugal
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CINTESIS, Center for Health Technology and Services Research, University of Porto, Porto, Portugal
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Sandra Rebelo
Sandra Rebelo
Department of Biomedicine, Faculty of Medicine of the University of Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Department of Clinical Pathology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Department of Clinical Pathology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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Duarte Pignatelli
Duarte Pignatelli
Department of Biomedicine, Faculty of Medicine of the University of Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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, mirroring their differences in study design, methodological quality, and sample size. Thus, this systematic review aims to determine the frequency of pheochromocytoma and/or PPGL in patients with vHL (and in patients with each vHL subtype), as well as to
Samira M Sadowski
Samira M Sadowski
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Emanuel Christ
Emanuel Christ
Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, Basel, Switzerland
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Benoit Bédat
Benoit Bédat
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Attila Kollár
Attila Kollár
Department of Medical Oncology, Inselspital, University of Bern, Bern, Switzerland
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Wolfram Karenovics
Wolfram Karenovics
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Aurel Perren
Aurel Perren
Institute of Pathology, University of Bern, Bern, Switzerland
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Frédéric Triponez
Frédéric Triponez
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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on behalf of the SwissNET registry
on behalf of the SwissNET registry
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therapy are not standard of care. SwissNET is a prospective ongoing nationwide registry of patients with NET of all organs. Its goal is to collect data from NET cases in order to provide quality assessments, to advance knowledge and to establish standard
Ann R Webb
Ann R Webb
Department of Earth and Environmental Sciences, University of Manchester, Manchester, UK
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Rehab Alghamdi
Rehab Alghamdi
Department of Earth and Environmental Sciences, University of Manchester, Manchester, UK
Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
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Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
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Richard Kift
Richard Kift
Department of Earth and Environmental Sciences, University of Manchester, Manchester, UK
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Lesley E Rhodes
Lesley E Rhodes
Centre for Dermatology Research, School of Biological Sciences, The University of Manchester and Salford Royal NHS Foundation Trust, Manchester, UK
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regime was in addition to prescribed supplements. Quality assessment of studies The methodological quality of the 22 studies using artificial sources of UV was assessed by two researchers (RA and ARW), and scoring was further checked (LER
Elena Valassi
Elena Valassi
Endocrinology Department, Germans Trias i Pujol Hospital and Research Institute, Badalona, Barcelona, Spain
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Iacopo Chiodini
Iacopo Chiodini
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Richard A Feelders
Richard A Feelders
Division of Endocrinology, Erasmus Medical Centre, Rotterdam, Netherlands
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Cornelie D Andela
Cornelie D Andela
Division of Endocrinology and Centre for Endocrine Tumours, Leiden University Medical Centre, Leiden, Netherlands
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Margueritta Abou-Hanna
Margueritta Abou-Hanna
HRA Pharma Rare Diseases, Châtillon, France
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Sarah Idres
Sarah Idres
HRA Pharma Rare Diseases, Châtillon, France
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Antoine Tabarin
Antoine Tabarin
Department of Endocrinology and INSERM U862 University and CHU of Bordeaux, Pessac, France
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patients who have been biochemically ‘cured’ for over 10 years have a residual overall higher risk of mortality, mostly from circulatory disease and diabetes ( 5 ). Moreover, people with a history of CS suffer from impaired quality of life (QoL) ( 6
Christian Trummer
Christian Trummer
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Stefan Pilz
Stefan Pilz
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Verena Schwetz
Verena Schwetz
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Barbara Obermayer-Pietsch
Barbara Obermayer-Pietsch
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Elisabeth Lerchbaum
Elisabeth Lerchbaum
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
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Andersson AM Petersen JH Nordkap L Bang AK Ekbom P Joensen UN Prætorius L Lundstrøm P , et al . Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men . Human Reproduction 2016 31 1875
Michaela Keuper
Michaela Keuper
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
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cross-species comparisons, MΦ may not always be the most abundant immune cell type in adipose tissue. Nevertheless, MΦ are present in scWAT and viscWAT with increasing numbers during obesity. Furthermore, the obese condition alters their quality
Mírian Romitti
Mírian Romitti
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Vitor C Fabris
Vitor C Fabris
Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Patricia K Ziegelmann
Patricia K Ziegelmann
Postgraduate Program in Epidemiology and Department of Statistics, Institute of Mathematics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Ana Luiza Maia
Ana Luiza Maia
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Poli Mara Spritzer
Poli Mara Spritzer
Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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and exclusion criteria, the full text was retrieved for evaluation. Data extraction and quality control Two investigators (M R and V C F) independently reviewed the titles and abstracts of all articles identified in the initial search to assess
Gudmundur Johannsson
Gudmundur Johannsson
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Martin Bidlingmaier
Martin Bidlingmaier
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Beverly M K Biller
Beverly M K Biller
Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
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Margaret Boguszewski
Margaret Boguszewski
Federal University of Parana, Curitiba, Brazil
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Felipe F Casanueva
Felipe F Casanueva
Department of Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
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Philippe Chanson
Philippe Chanson
Assistance Publique-Hôpitaux de Paris, and Inserm, Paris, France
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Peter E Clayton
Peter E Clayton
Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK
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Catherine S Choong
Catherine S Choong
Department of Endocrinology, Princess Margaret Hospital & School of Medicine, University of Western Australia, Western Australia, Australia
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David Clemmons
David Clemmons
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
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Mehul Dattani
Mehul Dattani
Great Ormond Street Institute of Child Health, London, UK
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Jan Frystyk
Jan Frystyk
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Ken Ho
Ken Ho
Princess Alexandra Hospital and University of Queensland, Brisbane, Australia
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Andrew R Hoffman
Andrew R Hoffman
Department of Medicine, Stanford University and VA Palo Health Care System, Palo Alto, California, USA
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Reiko Horikawa
Reiko Horikawa
National Center for Child Health and Development, Tokyo, Japan
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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John J Kopchick
John J Kopchick
Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Xiaoping Luo
Xiaoping Luo
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Sebastian Neggers
Sebastian Neggers
Section of Endocrinology, Department of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands
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Irene Netchine
Irene Netchine
Service d’Explorations Fonctionnelles Endocriniennes, AP-HP, Hôpital Trousseau, Sorbonne Université, INSERM UMRs 938, Paris, France
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Daniel S Olsson
Daniel S Olsson
Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden
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Sally Radovick
Sally Radovick
Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
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Ron Rosenfeld
Ron Rosenfeld
Department of Pediatrics, Oregon Health Science University, Portland, Oregon, USA
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Richard J Ross
Richard J Ross
University of Sheffield, Sheffield, UK
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Katharina Schilbach
Katharina Schilbach
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Paulo Solberg
Paulo Solberg
Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
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Christian Strasburger
Christian Strasburger
Charité-Universitätsmedizin, Berlin, Germany
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Peter Trainer
Peter Trainer
The Christie NHS Foundation Trust, University of Manchester, Manchester, UK
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Kevin C J Yuen
Kevin C J Yuen
Barrow Pituitary Center, Barrow Neurological Institute, Department of Neuroendocrinology, University of Arizona College of Medicine, Phoenix, Arizona, USA
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Kerstin Wickstrom
Kerstin Wickstrom
Medical Products Agency, Uppsala, Sweden
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Jens O L Jorgensen
Jens O L Jorgensen
Aarhus University Hospital, Aarhus, Denmark
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on behalf of the Growth Hormone Research Society
on behalf of the Growth Hormone Research Society
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replacement in adults with GHD include body composition and quality of life (QoL). Measurement of body composition may include waist circumference, dual-energy X-ray absorptiometry (DXA) scan for bone mineral density and content (BMD/BMC), and where available
