INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France
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using a meta-analytic approach. Overall, there is no evidence of beneficial effects of intensive glycaemic control on cognitive decline. A beneficial effect was observed in only one trial targeting elderly persons with well-controlled type 2 diabetes
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role of IGF1 in the management of patients with delayed puberty or hypogonadotropic hypogonadism. It is concerning that the evidence in humans is scarce, as the IGF1R knockout is incompatible with life. The human phenotype that is closest to the animal
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paediatric population, the fact remains that the adverse effects of therapy with levothyroxine in this special population are not known ( 28 , 29 ). In this scenario, it becomes essential to provide real-world evidence on SH in paediatric population
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
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Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
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exclude LN metastasis is based on factual evidence. For this purpose, we have tabled the actual data reported by the authors and have analysed whether their use of the terms ‘sensitivity’ and ‘negative predictive value’ (NPV) conforms to textbook
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Imperial College London, Institute of Reproductive and Developmental Biology, London, UK
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Malmö University Hospital, Reproductive Medicine Center, Malmö, Sweden
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spermatozoa. Possibly, and perhaps even likely, prostate cancer cells utilize the same process for growth and progression to an incurable disease, but in healthy men, we do not find evidence for this to be the situation. The response of inhibin B levels to
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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disadvantage after preterm birth ( 13 ). Although sex differences in HPA axis activity have been postulated to emerge during puberty, recent evidence suggests that such differences are already present early in life ( 14 , 15 ). However, little is known about
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is believed that tumor grade may reflect inherent tumor aggressiveness. However, emerging evidence suggests that the 2010 WHO G3 category may not sufficiently distinguish highly proliferative WD-pNETs from PD-pNECs due to the lack of well
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. Evidence-Based Complementary and Alternative Medicine 2015 2015 1 – 10 . ( doi:10.1155/2015/439258 ) 17 Shozu M Zhao Y Simpson ER. Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene
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Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany
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German Center of Diabetes Research (DZD), München-Neuherberg, Germany
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biomarkers essentially add to the growing body of evidence implicating chemerin as a biomarker linking immunity and metabolism in relation to chronic disease risk and point to pathways implicated in adipokine production beyond adiposity per se . Our study
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)D elevation. Therefore, there is contradictory evidence regarding this issue, and the accurate relationship between vitamin D and adiposity indicators remains unclear. According to the results of the studies included in the systematic review, overweight and