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found no sign of Cushing’s syndrome. Evaluation of adrenal hormone revealed loss of cortisol rhythm (8:00–16:00–24:00 25.81–25.77–23.82 μg/dL) and elevated urinary free cortisol (UFC) (1287 μg/24 h, normal 21–111 μg/24 h). Overnight dexamethasone
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KORA Study Centre, University Hospital of Augsburg, Augsburg, Augsburg, Germany
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German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany
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German Heart Centre Munich, Technical University of Munich, Munich, Germany
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
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German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
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transitions. According to the manufacturer, all calibrators and QCs are traceable to certified reference materials, or, if not available for certain steroid, to primary standards. For cortisol, progesterone and testosterone NIST 971 reference material is used
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Introduction Cushing’s syndrome (CS) is a morbid endocrine condition due to prolonged exposure to high circulating cortisol levels ( 1 , 2 , 3 ). Hypercortisolism may cause irreversible physical and psychological changes in several tissues
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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, cortisol (F), and insulin were measured using a chemiluminescence assay with a sensitivity of 1.0 nmol/L, 0.08 µmol/L, 0.19 nmol/L, and 2 µIU/mL, respectively (Siemens Medical Solution Diagnostics, CA, USA). The intra- and inter-assay coefficients of
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factors include advanced tumor stage, cortisol excess, and older age ( 18 ). In addition, poor prognosis is associated with pathologic factors, including tumor grade, mitotic count, Ki-67 proliferation index ( 21 ), resection status ( 22 ), and results of
Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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RV. ACTH, adrenocorticotropic hormone; anti-TPO, anti-thyroid peroxidase antibodies; GHRH–arginine, growth hormone-releasing hormone and arginine; ITT, insulin tolerance test; MRI, magnetic resonance imaging; S-cortisol, serum cortisol; S-IGF1, serum
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have a negative feedback on the release of CRH and AVP at the hypothalamus and ACTH at the pituitary, thus providing tight regulation of cortisol production. ACTH receptor/melanocortin-2-receptor The ACTH receptor (also known as the melanocortin
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Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany
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hypercortisolism ( 36 ). Furthermore, TL has been evaluated in other conditions with increased endogenous cortisol such as chronic stress exposure and post-traumatic stress disorder ( 37 ). Shorter TL has been reported for both neuropsychiatric conditions
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of GCs in PAI and CAH still tends to be more than the total daily endogenous cortisol secretion seen in healthy subjects (5–10 mg of cortisol/m 2 of body surface area/day) ( 1 ) possibly triggering long-term morbidities such as osteoporosis. GC
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cortisol at 08:00 h (29 µg/dL; n.v. 5–25), and high urinary free cortisol (UFC) (280 µg/24 h; n.v. 36–137), while ACTH levels at 08:00 h were in the normal range (26 pg/mL; n.v. 10–50). The patient’s diabetes was poorly controlled (HbA1c 8%). The