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Jian Ding Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China
Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

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Yan Kang Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China
Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

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Yuqin Fan Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China
Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

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Qi Chen Department of Obstetrics and Gynecology, Zoucheng People’s Hospital, Zoucheng, Shandong Province, China

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placenta, adipose tissue and skeletal muscle . PLoS ONE 2017 12 e0173373 . ( doi:10.1371/journal.pone.0173373 ) 28278187 10.1371/journal.pone.0173373 24 Dragan I Wright D Fiolna M Leipold G Nicolaides KH. Development of pre-eclampsia within 4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0130
Volume/Issue:
Volume 6: Issue 8
Open access
Julie Refardt Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Clara Odilia Sailer Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Bettina Winzeler Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Matthias Johannes Betz Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Irina Chifu Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Ingeborg Schnyder Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Martin Fassnacht Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Central Laboratory, University Hospital Würzburg, Würzburg, Germany

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Wiebke Fenske Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany
Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany

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Mirjam Christ-Crain Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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for the CODDI-Investigators
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for the CODDI-Investigators

several organs (e.g. liver, brown adipose tissue, muscle, pancreas). It is involved in the regulation of energy homeostasis and triggered by metabolic stress ( 5 , 6 ). Thus, the main focus on FGF-21 to date is due to its involvement in the metabolic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0469
Volume/Issue:
Volume 7: Issue 12
Open access
John E M Midgley
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Rolf Larisch North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK

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Johannes W Dietrich North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK
North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK

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Rudolf Hoermann North Lakes Clinical, Department of Nuclear Medicine, Medical Department I, Ruhr Center for Rare Diseases (CeSER), 20 Wheatley Avenue, Ilkley LS29 8PT, UK

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that rT 3 , when infused into rats, inhibited deiodinase type 2 activity in the pituitary, cerebral cortex and brown adipose tissue, but interestingly, this did not have much impact on circulating T 4 , T 3 and TSH concentrations in the animals

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0056
Volume/Issue:
Volume 4: Issue 4
Open access
Jeyanthini Risikesan Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Birgitte Nellemann Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

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Britt Christensen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Jens Otto Lunde Jørgensen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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Søren Nielsen Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

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glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice . PLoS ONE 2017 12 e0173661. ( https://doi.org/10.1371/journal.pone.0173661 ) 11 Christensen B Nellemann B

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0305
Volume/Issue:
Volume 9: Issue 12
Open access
Vittorio Unfer Health Department, UniPoliSi – Institut des Etudes Universitaires, Disentis, Switzerland

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Fabio Facchinetti Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy

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Beatrice Orrù Medical Affairs Department, Lo.Li. Pharma, Rome, Italy

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Barbara Giordani Medical Affairs Department, Lo.Li. Pharma, Rome, Italy

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John Nestler Departments of Medicine and Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, USA

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downregulating the release of free fatty acids (FFA) from adipose tissues, hindering the enzyme adenylate cyclase. Indeed, FFA are known to reduce glucose disposal, causing IR and increased triglyceride synthesis. DCI upregulates pyruvate dehydrogenase leading to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0243
Volume/Issue:
Volume 6: Issue 8
Open access
Kaisu Luiro Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

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Kristiina Aittomäki Department of Medical Genetics, Helsinki University Hospital, Helsinki, Finland

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Pekka Jousilahti Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland

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Juha S Tapanainen Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland

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FSH has recently been shown to induce thermogenic adipose tissue and reduce body fat in wild-type mice ( 32 ). Our clinical findings in women with defective FSHR function do not support the proposed therapeutic potential of FSH-blocking agents in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0244
Volume/Issue:
Volume 8: Issue 10
Open access
Aneta Gawlik Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland

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Michael Shmoish Bioinformatics Knowledge Unit, Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion – Israel Institute of Technology, Haifa, Israel

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Michaela F Hartmann Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany

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Stefan A Wudy Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany

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Zbigniew Olczak Department of Diagnostic Imaging, Upper Silesia Children’s Care Health Centre, Katowice, Poland

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Katarzyna Gruszczynska Department of Diagnostic Imaging, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland

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Ze’ev Hochberg Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel

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DHEA might have a protective effect against hepatotoxicity. It has been shown that DHEA inhibits 11β-hydroxysteroid dehydrogenase-1 expression in liver and adipose tissues ( 23 ) – another component of the steroidal signature. The liver is also the site

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0536
Volume/Issue:
Volume 8: Issue 6
Open access
Katica Bajuk Studen Nuclear Medicine Department, University Medical Centre Ljubljana, Ljubljana, Slovenia

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Marija Pfeifer Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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tissue level, insulin resistance is present in the liver, adipose tissue and muscles of these patients. The PCOS-associated insulin resistance is selective, affecting metabolic, but not mitogenic, signaling pathways, which might explain the paradox of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0129
Volume/Issue:
Volume 7: Issue 7
Open access
Qiu-ming Yao Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Bin Wang Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Xiao-fei An Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Jin-an Zhang Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China

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Liumei Ding Department of Clinical Laboratory, Jinshan Hospital of Fudan University, Shanghai, China

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cause T2DM. In one study, testicular feminized mice with testosterone deficiency have a reduced GLUT4 level in muscle and a decreased glycolytic enzyme activity in muscle, liver and abdominal adipose tissues ( 57 ). Thirdly, obesity caused by

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0253
Volume/Issue:
Volume 7: Issue 1
Open access
Sirazum Choudhury Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Tricia Tan Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Katharine Lazarus Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Karim Meeran Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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hepatic adiposity on CT imaging, as well as a higher fasting triglycerides and lower HDL ( 13 ). These surrogate endpoints suggest that higher doses of glucocorticoid replacement induce a metabolic syndrome which likely drives an excess risk of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0473
Volume/Issue:
Volume 10: Issue 2
Open access