Teodoro Durá-Travé
Teodoro Durá-Travé
Department of Pediatrics, School of Medicine, University of Navarra, Pamplona, Spain
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by Teodoro Durá-Travé in
Google Scholar
PubMed
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by Teodoro Durá-Travé in
Google Scholar
PubMed
Fidel Gallinas-Victoriano
Fidel Gallinas-Victoriano
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Search for other papers by Fidel Gallinas-Victoriano in
Google Scholar
PubMed
Search for other papers by Fidel Gallinas-Victoriano in
Google Scholar
PubMed
María Malumbres-Chacon
María Malumbres-Chacon
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Search for other papers by María Malumbres-Chacon in
Google Scholar
PubMed
Search for other papers by María Malumbres-Chacon in
Google Scholar
PubMed
Lotfi Ahmed-Mohamed
Lotfi Ahmed-Mohamed
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Search for other papers by Lotfi Ahmed-Mohamed in
Google Scholar
PubMed
Search for other papers by Lotfi Ahmed-Mohamed in
Google Scholar
PubMed
María Jesús Chueca -Guindulain
María Jesús Chueca -Guindulain
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by María Jesús Chueca -Guindulain in
Google Scholar
PubMed
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by María Jesús Chueca -Guindulain in
Google Scholar
PubMed
Sara Berrade-Zubiri
Sara Berrade-Zubiri
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by Sara Berrade-Zubiri in
Google Scholar
PubMed
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by Sara Berrade-Zubiri in
Google Scholar
PubMed
personal data (age at onset of breast budding, weight and height, BMI, and bone age), and GnRHa-stimulation testing results. Weight and height of all the participants had been previously recorded by the pediatrician at the Primary Health Care Center
Rui-yi Tang
Rui-yi Tang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
Search for other papers by Rui-yi Tang in
Google Scholar
PubMed
Search for other papers by Rui-yi Tang in
Google Scholar
PubMed
Rong Chen
Rong Chen
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
Search for other papers by Rong Chen in
Google Scholar
PubMed
Search for other papers by Rong Chen in
Google Scholar
PubMed
Miao Ma
Miao Ma
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
Search for other papers by Miao Ma in
Google Scholar
PubMed
Search for other papers by Miao Ma in
Google Scholar
PubMed
Shou-qing Lin
Shou-qing Lin
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
Search for other papers by Shou-qing Lin in
Google Scholar
PubMed
Search for other papers by Shou-qing Lin in
Google Scholar
PubMed
Yi-wen Zhang
Yi-wen Zhang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
Search for other papers by Yi-wen Zhang in
Google Scholar
PubMed
Search for other papers by Yi-wen Zhang in
Google Scholar
PubMed
Ya-ping Wang
Ya-ping Wang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
Search for other papers by Ya-ping Wang in
Google Scholar
PubMed
Search for other papers by Ya-ping Wang in
Google Scholar
PubMed
). Cases of KS account for approximately 40–60% of all IHH cases ( 3 , 4 ). IHH negatively affects patients’ sexual, bone and metabolic health, as well as their psychological development ( 5 , 6 ). Thus, a precise early diagnosis and timely treatment
Emma Jernberg
Emma Jernberg
Department of Medical biosciences, Umeå University, Umeå, Sweden
Search for other papers by Emma Jernberg in
Google Scholar
PubMed
Search for other papers by Emma Jernberg in
Google Scholar
PubMed
Anders Bergh
Anders Bergh
Department of Medical biosciences, Umeå University, Umeå, Sweden
Search for other papers by Anders Bergh in
Google Scholar
PubMed
Search for other papers by Anders Bergh in
Google Scholar
PubMed
Pernilla Wikström
Pernilla Wikström
Department of Medical biosciences, Umeå University, Umeå, Sweden
Search for other papers by Pernilla Wikström in
Google Scholar
PubMed
Search for other papers by Pernilla Wikström in
Google Scholar
PubMed
reduces tumour growth. Although ADT is initially effective in most patients, the disease progresses within a few years into an incurable and lethal stage of castration resistance. Castration-resistant prostate cancer (CRPC) is usually established as bone
Zeeshan Javed
Zeeshan Javed
Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan
Search for other papers by Zeeshan Javed in
Google Scholar
PubMed
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan
Search for other papers by Zeeshan Javed in
Google Scholar
PubMed
Maria Papageorgiou
Maria Papageorgiou
Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
Search for other papers by Maria Papageorgiou in
Google Scholar
PubMed
Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
Search for other papers by Maria Papageorgiou in
Google Scholar
PubMed
Leigh A Madden
Leigh A Madden
School of Life Sciences, University of Hull, Hull, UK
Search for other papers by Leigh A Madden in
Google Scholar
PubMed
Search for other papers by Leigh A Madden in
Google Scholar
PubMed
Alan S Rigby
Alan S Rigby
Hull York Medical School, University of Hull, Hull, UK
Search for other papers by Alan S Rigby in
Google Scholar
PubMed
Search for other papers by Alan S Rigby in
Google Scholar
PubMed
Eric S Kilpatrick
Eric S Kilpatrick
Department of Pathology, Sidra Medical and Research Center, Doha, Qatar
Search for other papers by Eric S Kilpatrick in
Google Scholar
PubMed
Search for other papers by Eric S Kilpatrick in
Google Scholar
PubMed
Stephen L Atkin
Stephen L Atkin
Royal College of Surgeons in Ireland, Al Sayh, Bahrain
Search for other papers by Stephen L Atkin in
Google Scholar
PubMed
Search for other papers by Stephen L Atkin in
Google Scholar
PubMed
Thozhukat Sathyapalan
Thozhukat Sathyapalan
Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
Search for other papers by Thozhukat Sathyapalan in
Google Scholar
PubMed
Search for other papers by Thozhukat Sathyapalan in
Google Scholar
PubMed
Context
Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managing PCOS affect EMP levels.
Objective
To characterise and compare the effects of empagliflozin vs metformin on the circulating levels of EMPs in overweight/obese women with PCOS.
Methods
This was a randomised, comparative, 12-week single-centre trial conducted at the Academic Diabetes, Endocrinology and Metabolism Research Centre, Hull, UK. This analysis includes data from 39 overweight/obese women with PCOS who completed the study and were randomised to empagliflozin (15 mg/day) (n = 19) or metformin (1500 mg/day) (n = 20). Blood samples were collected at baseline and 12 weeks after treatment and analysed for specific surface proteins (ICAM-1, VCAM-1, PECAM-1, E-selectin and endoglin) expressed by circulating EMPs using flow cytometry.
Results
In the empagliflozin group, ICAM-1 (P = 0.006), E-selectin (P = 0.016) and VCAM-1 (P = 0.001) EMPs increased significantly following 12 weeks of treatment, but no changes were seen in PECAM-1 (P = 0.93) or endoglin (P = 0.13) EMPs. In the metformin group, VCAM-1 EMPs (P < 0.001) increased significantly after 12 weeks of treatment, whereas all other EMPs remained unchanged. When data were expressed as percentage change from baseline in each group, no significant differences were seen between groups for any biomarker (P-values from 0.22 to 0.80).
Conclusions
Short-term administration of empagliflozin and metformin in overweight/obese women with PCOS appear to increase EMPs expressed by endothelial cells during their activation.
Rimesh Pal
Rimesh Pal
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Rimesh Pal in
Google Scholar
PubMed
Search for other papers by Rimesh Pal in
Google Scholar
PubMed
Sanjay Kumar Bhadada
Sanjay Kumar Bhadada
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Sanjay Kumar Bhadada in
Google Scholar
PubMed
Search for other papers by Sanjay Kumar Bhadada in
Google Scholar
PubMed
Awesh Singhare
Awesh Singhare
Department of Endocrinology, P D Hinduja Hospital and Medical Research Centre, Mumbai, India
Search for other papers by Awesh Singhare in
Google Scholar
PubMed
Search for other papers by Awesh Singhare in
Google Scholar
PubMed
Anil Bhansali
Anil Bhansali
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Anil Bhansali in
Google Scholar
PubMed
Search for other papers by Anil Bhansali in
Google Scholar
PubMed
Sadishkumar Kamalanathan
Sadishkumar Kamalanathan
Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry, India
Search for other papers by Sadishkumar Kamalanathan in
Google Scholar
PubMed
Search for other papers by Sadishkumar Kamalanathan in
Google Scholar
PubMed
Manoj Chadha
Manoj Chadha
Department of Endocrinology, P D Hinduja Hospital and Medical Research Centre, Mumbai, India
Search for other papers by Manoj Chadha in
Google Scholar
PubMed
Search for other papers by Manoj Chadha in
Google Scholar
PubMed
Phulrenu Chauhan
Phulrenu Chauhan
Department of Endocrinology, P D Hinduja Hospital and Medical Research Centre, Mumbai, India
Search for other papers by Phulrenu Chauhan in
Google Scholar
PubMed
Search for other papers by Phulrenu Chauhan in
Google Scholar
PubMed
Ashwani Sood
Ashwani Sood
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Ashwani Sood in
Google Scholar
PubMed
Search for other papers by Ashwani Sood in
Google Scholar
PubMed
Vandana Dhiman
Vandana Dhiman
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Vandana Dhiman in
Google Scholar
PubMed
Search for other papers by Vandana Dhiman in
Google Scholar
PubMed
Dinesh Chandra Sharma
Dinesh Chandra Sharma
Division of Endocrinology, Rabindranath Tagore Medical College, Udaipur, India
Search for other papers by Dinesh Chandra Sharma in
Google Scholar
PubMed
Search for other papers by Dinesh Chandra Sharma in
Google Scholar
PubMed
Uma Nahar Saikia
Uma Nahar Saikia
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Uma Nahar Saikia in
Google Scholar
PubMed
Search for other papers by Uma Nahar Saikia in
Google Scholar
PubMed
Debajyoti Chatterjee
Debajyoti Chatterjee
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Search for other papers by Debajyoti Chatterjee in
Google Scholar
PubMed
Search for other papers by Debajyoti Chatterjee in
Google Scholar
PubMed
Vikas Agashe
Vikas Agashe
Department of Orthopaedics, P D Hinduja Hospital and Medical Research Centre, Mumbai, India
Search for other papers by Vikas Agashe in
Google Scholar
PubMed
Search for other papers by Vikas Agashe in
Google Scholar
PubMed
further impairs intestinal absorption of phosphate and deters mineralization of the osteoid matrix. Chronic hypophosphatemia leads to skeletal manifestations of osteomalacia in adults and rickets in children ( 11 ). Adults complain of bone pains, fatigue
Yuan Liu
Yuan Liu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Yuan Liu in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Yuan Liu in
Google Scholar
PubMed
Siyi Guo
Siyi Guo
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Siyi Guo in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Siyi Guo in
Google Scholar
PubMed
Jinsong Wu
Jinsong Wu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Jinsong Wu in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Jinsong Wu in
Google Scholar
PubMed
Rongai Wang
Rongai Wang
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Health Management Center, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Zhejiang, China
Search for other papers by Rongai Wang in
Google Scholar
PubMed
Health Management Center, The Second Affiliated Hospital of Zhejiang Chinese Medicine University, Zhejiang, China
Search for other papers by Rongai Wang in
Google Scholar
PubMed
Jinbo Liu
Jinbo Liu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Jinbo Liu in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Jinbo Liu in
Google Scholar
PubMed
Yan Liu
Yan Liu
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Yan Liu in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Yan Liu in
Google Scholar
PubMed
Bin Lv
Bin Lv
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China
Search for other papers by Bin Lv in
Google Scholar
PubMed
Search for other papers by Bin Lv in
Google Scholar
PubMed
Nan Liu
Nan Liu
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China
Search for other papers by Nan Liu in
Google Scholar
PubMed
Search for other papers by Nan Liu in
Google Scholar
PubMed
Ling Jiang
Ling Jiang
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Ling Jiang in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Ling Jiang in
Google Scholar
PubMed
Xiaoli Zhang
Xiaoli Zhang
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Xiaoli Zhang in
Google Scholar
PubMed
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, China
Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine & Health, Jinan, China
Search for other papers by Xiaoli Zhang in
Google Scholar
PubMed
by hypercalcemia. Typical symptoms are mainly musculoskeletal (bone pain, fracture), urological (urolithiasis, polyuria, and hematuria), gastrointestinal (nausea, vomiting, and loss of appetite), and neuropsychiatric (fatigue, dizziness, and
Barbara J Boucher
Barbara J Boucher
Blizard Institute, Barts & The London school of Medicine & Dentistry, Queen Mary University of London, London, UK
Search for other papers by Barbara J Boucher in
Google Scholar
PubMed
Search for other papers by Barbara J Boucher in
Google Scholar
PubMed
inadequacy with the reappearance of rickets and osteomalacia, the classic bone diseases seen in vitamin D deficiency ( 23 ). Though most countries provide guidance on recommended daily intakes of vitamin D, especially in infants and children, actual intakes
Mirjana Doknic
Mirjana Doknic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Mirjana Doknic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Mirjana Doknic in
Google Scholar
PubMed
Marko Stojanovic
Marko Stojanovic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Marko Stojanovic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Marko Stojanovic in
Google Scholar
PubMed
Ivan Soldatovic
Ivan Soldatovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Medical Statistics and Informatics, Belgrade, Serbia
Search for other papers by Ivan Soldatovic in
Google Scholar
PubMed
Institute of Medical Statistics and Informatics, Belgrade, Serbia
Search for other papers by Ivan Soldatovic in
Google Scholar
PubMed
Tatjana Milenkovic
Tatjana Milenkovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Tatjana Milenkovic in
Google Scholar
PubMed
Search for other papers by Tatjana Milenkovic in
Google Scholar
PubMed
Vera Zdravkovic
Vera Zdravkovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Vera Zdravkovic in
Google Scholar
PubMed
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Vera Zdravkovic in
Google Scholar
PubMed
Maja Jesic
Maja Jesic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Maja Jesic in
Google Scholar
PubMed
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Maja Jesic in
Google Scholar
PubMed
Sladjana Todorovic
Sladjana Todorovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Sladjana Todorovic in
Google Scholar
PubMed
Search for other papers by Sladjana Todorovic in
Google Scholar
PubMed
Katarina Mitrovic
Katarina Mitrovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Katarina Mitrovic in
Google Scholar
PubMed
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Katarina Mitrovic in
Google Scholar
PubMed
Rade Vukovic
Rade Vukovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Rade Vukovic in
Google Scholar
PubMed
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Rade Vukovic in
Google Scholar
PubMed
Dragana Miljic
Dragana Miljic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Dragana Miljic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Dragana Miljic in
Google Scholar
PubMed
Dragan Savic
Dragan Savic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Dragan Savic in
Google Scholar
PubMed
Search for other papers by Dragan Savic in
Google Scholar
PubMed
Mihajlo Milicevic
Mihajlo Milicevic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Mihajlo Milicevic in
Google Scholar
PubMed
Search for other papers by Mihajlo Milicevic in
Google Scholar
PubMed
Aleksandar Stanimirovic
Aleksandar Stanimirovic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Aleksandar Stanimirovic in
Google Scholar
PubMed
Search for other papers by Aleksandar Stanimirovic in
Google Scholar
PubMed
Vojislav Bogosavljevic
Vojislav Bogosavljevic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Vojislav Bogosavljevic in
Google Scholar
PubMed
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Vojislav Bogosavljevic in
Google Scholar
PubMed
Sandra Pekic
Sandra Pekic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Sandra Pekic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Sandra Pekic in
Google Scholar
PubMed
Emilija Manojlovic-Gacic
Emilija Manojlovic-Gacic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Emilija Manojlovic-Gacic in
Google Scholar
PubMed
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Emilija Manojlovic-Gacic in
Google Scholar
PubMed
Aleksandar Djukic
Aleksandar Djukic
Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Search for other papers by Aleksandar Djukic in
Google Scholar
PubMed
Search for other papers by Aleksandar Djukic in
Google Scholar
PubMed
Danica Grujicic
Danica Grujicic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Danica Grujicic in
Google Scholar
PubMed
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Danica Grujicic in
Google Scholar
PubMed
Milan Petakov
Milan Petakov
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Milan Petakov in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Milan Petakov in
Google Scholar
PubMed
, length of the gap in rhGH between pediatric and adult endocrine care or in comorbidities. Reported studies are inconsistent regarding the anthropometric characteristics, metabolic profile alteration, body composition (BC) deterioration or bone mineral
Claire L Wood
Claire L Wood
Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Claire L Wood in
Google Scholar
PubMed
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Claire L Wood in
Google Scholar
PubMed
Kieren G Hollingsworth
Kieren G Hollingsworth
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Kieren G Hollingsworth in
Google Scholar
PubMed
Search for other papers by Kieren G Hollingsworth in
Google Scholar
PubMed
Edrina Bokaie
Edrina Bokaie
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Edrina Bokaie in
Google Scholar
PubMed
Search for other papers by Edrina Bokaie in
Google Scholar
PubMed
Eric Hughes
Eric Hughes
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Eric Hughes in
Google Scholar
PubMed
Search for other papers by Eric Hughes in
Google Scholar
PubMed
Robert Muni-Lofra
Robert Muni-Lofra
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Robert Muni-Lofra in
Google Scholar
PubMed
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Robert Muni-Lofra in
Google Scholar
PubMed
Anna Mayhew
Anna Mayhew
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Anna Mayhew in
Google Scholar
PubMed
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Anna Mayhew in
Google Scholar
PubMed
Rod T Mitchell
Rod T Mitchell
MRC Centre for Reproductive Health, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
Search for other papers by Rod T Mitchell in
Google Scholar
PubMed
Search for other papers by Rod T Mitchell in
Google Scholar
PubMed
Michela Guglieri
Michela Guglieri
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Michela Guglieri in
Google Scholar
PubMed
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Michela Guglieri in
Google Scholar
PubMed
Joseph McElvaney
Joseph McElvaney
Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Search for other papers by Joseph McElvaney in
Google Scholar
PubMed
Search for other papers by Joseph McElvaney in
Google Scholar
PubMed
Timothy D Cheetham
Timothy D Cheetham
Department of Paediatric Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Timothy D Cheetham in
Google Scholar
PubMed
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Timothy D Cheetham in
Google Scholar
PubMed
Volker Straub
Volker Straub
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Volker Straub in
Google Scholar
PubMed
John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Search for other papers by Volker Straub in
Google Scholar
PubMed
is stopped, particularly in the context of ongoing GC therapy. Having shown a beneficial effect of testosterone on muscle, bone, and quality of life, it is important to explore whether these young men benefit from ongoing testosterone supplementation
Glenville Jones
Glenville Jones
Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
Search for other papers by Glenville Jones in
Google Scholar
PubMed
Search for other papers by Glenville Jones in
Google Scholar
PubMed
course, there were no precise medical details that distinguished it from other bone diseases, but treatises describing the symptoms and lithographs from that time showing bone deformities resembling rickets leave little doubt that it was vitamin D
