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factors, including leptin, adiponectin, ghrelin, and insulin, which are known to have an impact on puberty initiation ( 7 ). It is known that obese boys and girls tend to undergo an earlier timing of puberty ( 8 ). A certain threshold of body fat stores (i
National Hospital for Neurology and Neurosurgery, London, UK
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potentially lifesaving in these patients In adults, hydrocortisone 100 mg i.m. bolus followed by 50–100 mg six hourly by intramuscular injection or 100–200 mg as an intravenous bolus followed by 2–4 mg per hour by continuous i.v. infusion can be used
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anabolic processes are prioritized, allowing for the storage of more fat and energy. In late pregnancy, the i.v. glucose tolerance test shows that insulin in the first and second secretory phases increases three-fold after stimulation possibly to compensate
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_2021_modifica_nota_39.pdf ) 25 Tirosh A Toledano Y Masri-Iraqi H Eizenberg Y Tzvetov G Hirsch D Benbassat C Robenshtok E & Shimon I . IGF-I levels reflect hypopituitarism severity in adults with pituitary dysfunction . Pituitary 2016 19
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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i.v. ghrelin infusion; to study direct effects of GH, healthy subjects were treated with GH in a period of 8 days. Insulin sensitivity assessed by the euglycemic clamp technique and measurements of serum RBP4 levels were recorded. Materials and
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-treatment and on-treatment safety and efficacy measures were evaluated using paired t -tests, Wilcoxon matched-pairs and Wilcoxon signed-rank tests. The data were analysed using the R software (R i386 3.4.3.lnk, Bell Laboratory, NJ, USA), and figures were
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Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, California, USA
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normal colon tissue ( 38 ). The IGF family has been shown to have mitogenic and anti-apoptotic effects on proliferation in various epithelial cells, including the colon ( 39 ). In addition, high blood levels of IGF-I and IGF-II have been shown to be
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), a cAMP analog, insulin and IGF-I in the presence of serum ( 8 ). During expression of the CYP19A1 gene in human fibroblasts, of the multiple exons I in the human CYP19A1 gene ( Fig. 1A ), exon I.4 (exon 1b) was mainly selected as the 5′-UTR of
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Internal Medicine, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy
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Istituto Auxologico Italiano, IRCCS, Obesity Unit - Laboratory of Nutrition and Obesity Research, Department of Endocrine and Metabolic Diseases, Milan, Italy
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.1210/jcem.85.12.7017 ) 37 Gahete MD Córdoba-Chacón J Lin Q Brüning JC Kahn CR Castaño JP Christian H Luque RM Kineman RD . Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms . Endocrinology
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Murillo M Salinas I Granada ML Martinez M Puig-Domingo M Andreu A Bel J . Variability in adherence to rhGH treatment: socioeconomic causes and effect on children’s growth . Growth Hormone and IGF Research 2016 26 32 – 35 . ( https