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Suvanjaa Sivalingam Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

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Marianne Thvilum Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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Thomas Heiberg Brix Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
Department of Clinical Research, University of Southern Denmark, Odense M, Denmark

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Frans Brandt Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark
Department of Regional Health Research, University of Southern Denmark, Odense M, Denmark

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, which causes hyperthyroidism due to the presence of autoantibodies, which stimulate thyroid follicular cells by binding to the TSH receptor ( 1 ). In TNG, hyperthyroidism is the result of autonomous thyroid nodules, which produce thyroid hormones

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Aaron Lerner B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
AESKU.KIPP Institute, Wendelsheim, Germany

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Patricia Jeremias AESKU.KIPP Institute, Wendelsheim, Germany

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Torsten Matthias AESKU.KIPP Institute, Wendelsheim, Germany

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ultrasound-guided fine-needle aspirates of thyroid nodules. Similar to majority of the other autoimmune diseases, HT is age dependent and is more common in women (F:M ratio >10:1) ( 1 ). It is identified by anti-thyroglobulin (TG) and/or anti

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Alessandro Brancatella Endocrine Unit 1, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Claudio Marcocci Endocrine Unit 2, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Metabolism 2010 95 4576 – 4583 . ( https://doi.org/10.1210/jc.2010-0161 ) 10.1210/jc.2010-0161 16 American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer , Cooper DS Doherty GM Haugen BR

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David T Broome Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Gauri B Gadre Department of Internal Medicine, Scripps Clinic, La Jolla, California, USA

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Ehsan Fayazzadeh Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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James F Bena Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Christian Nasr Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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GW Sawka AM Schlumberger M , 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and

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Catarina Tavares Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Maria João Coelho Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal

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Catarina Eloy Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Miguel Melo Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, University and Hospital Center of Coimbra, Coimbra, Portugal
Medical Faculty, University of Coimbra, Coimbra, Portugal

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Adriana Gaspar da Rocha Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Public Health Unit, ACeS Baixo Mondego, Coimbra, Portugal

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Ana Pestana Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Rui Batista Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Luciana Bueno Ferreira Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Elisabete Rios Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal

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Samia Selmi-Ruby Inserm UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Bruno Cavadas Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal

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Luísa Pereira Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Manuel Sobrinho Simões Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal

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Paula Soares Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal

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Sawka AM Schlumberger M 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and

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Giorgio Radetti Pediatrics, Regional Hospital, Bolzano, Italy

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Mariacarolina Salerno Pediatrics, University Federico II, Naples, Italy

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Chiara Guzzetti Pediatric Endocrinology, Ospedale Pedatrico Microcitemico ‘A. Cao’ – AOB Cagliari, Cagliari, Italy

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Marco Cappa Pediatric Endocrinology, Bambino Gesù Children Hospital, Roma, Italy

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Andrea Corrias Divisione di Endocrinologia Pediatrica, Ospedale Infantile Regina Margherita, Torino, Italy

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Alessandra Cassio Department of Pediatrics, University of Bologna, Bologna, Italy

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Graziano Cesaretti Department of Pediatrics, University of Pisa, Pisa, Italy

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Roberto Gastaldi Paediatric Department, Gaslini Hospital, Genova, Italy

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Mario Rotondi Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors, University of Pavia, Pavia, Italy

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Fiorenzo Lupi Pediatrics, Regional Hospital, Bolzano, Italy

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Antonio Fanolla Department of Biostatistics, Regional Hospital, Bolzano, Italy

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Giovanna Weber Department of Pediatrics, Vita-Salute San Raffaele University, Milan, Italy

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Sandro Loche Pediatric Endocrinology, Ospedale Pedatrico Microcitemico ‘A. Cao’ – AOB Cagliari, Cagliari, Italy

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Gastaldi R Einaudi S Baronio F Vigone MC Thyroid nodules and cancer in children and adolescents affected by autoimmune thyroiditis . Archives of Pediatrics and Adolescent Medicine 2008 162 526 – 531 . ( doi:10.1001/archpedi.162

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Mahmoud Al-Masri Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Tawfiq Al-Shobaki Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Hani Al-Najjar Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Rafal Iskanderian Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Enas Younis Department of Internal Medicine, Endocrine, King Hussein Cancer Center, Amman, Jordan

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Niveen Abdallah Department of Cell Therapy & Applied Genomics, King Hussein Cancer Center, Amman, Jordan

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Abdelghani Tbakhi Department of Cell Therapy & Applied Genomics, King Hussein Cancer Center, Amman, Jordan

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Hussam Haddad Department of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan

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Mohammad Al-Masri School of Medicine, University of Jordan, Amman, Jordan

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Zeinab Obeid Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Awad Jarrar Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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every 6–12 months after primary surgery. Suspicious thyroid nodules or lymph nodes warranted ultrasound-guided fine-needle aspiration cytology (US-FNAC). Tumour-node-metastasis (TNM) staging was defined based on the eighth edition of the American Joint

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Verônica Carneiro Borges Mioto Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas HCFMUSP-Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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Ana Carolina de Castro Nassif Gomes Monteiro Ultrasound Unit, Department of Radiology, Hospital das Clinicas HCFMUSP-Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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Rosalinda Yossie Asato de Camargo Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas HCFMUSP-Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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Andréia Rodrigues Borel Clinic of the Paraisópolis Community Einstein Project, Jewish School of Health Sciences Albert Einstein, Sao Paulo, Sao Paulo, Brazil

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Regina Maria Catarino Hematology and Biochemistry, Center of Pathology, Adolfo Lutz Institute, Sao Paulo, Sao Paulo, Brazil

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Sergio Kobayashi Ultrasound Unit, Department of Radiology, Hospital das Clinicas HCFMUSP-Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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Maria Cristina Chammas Ultrasound Unit, Department of Radiology, Hospital das Clinicas HCFMUSP-Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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Suemi Marui Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas HCFMUSP-Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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TSH. We found no correlation between TV and UIC. A thyroid nodule was detected in 19% of all pregnant patients. Figure 1 Relationship between body BMI and TV in pregnant women from an adequate iodine area. TV, thyroid volume. When

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Flávia O Valentim Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Bárbara P Coelho Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Hélio A Miot Department of Dermatology, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Caroline Y Hayashi Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Danilo T A Jaune Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Cristiano C Oliveira Pathology Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Mariângela E A Marques Pathology Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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José Vicente Tagliarini Otolaryngology and Head and Neck Surgery Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Emanuel C Castilho Otolaryngology and Head and Neck Surgery Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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Paula Soares i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
Cancer Signaling and Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal

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Gláucia M F S Mazeto Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil

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determine an efficient and accurate diagnostic method for follicular-patterned thyroid nodules ( 2 ). One of the techniques that has been used for this purpose is computerized image analysis of cell nuclei ( 4 , 5 , 7 , 8 , 12 , 18 , 19 , 20 , 21

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Sara Lomelino Pinheiro Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Ana Saramago Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Branca Maria Cavaco Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Carmo Martins Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Valeriano Leite Serviço de Endocrinologia e Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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Tiago Nunes da Silva Serviço de Endocrinologia e Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal

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. Medicina (Kaunas) 2011 47 635 – 639 . ( https://doi.org/10.3390/medicina47110092 ) 16 Lee KM Kim EJ Choi WS Park WS & Kim SW . Intrathyroidal parathyroid carcinoma mimicking a thyroid nodule in a MEN type 1 patient . Journal of Clinical

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