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Paraskevi Kazakou Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Stavroula A Paschou Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Theodora Psaltopoulou Unit of Hematology and Oncology, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Maria Gavriatopoulou Unit of Hematology and Oncology, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Eleni Korompoki Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Katerina Stefanaki Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Fotini Kanouta Department of Endocrinology, Alexandra Hospital, Athens, Greece

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Georgia N Kassi Department of Endocrinology, Alexandra Hospital, Athens, Greece

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Meletios-Athanasios Dimopoulos Unit of Hematology and Oncology, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Asimina Mitrakou Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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metabolism Diabetes mellitus (DM) has been in the highest rank of comorbidities in hospitalized patients with COVID-19 ( 1 , 12 ). Available evidence indicates that older adults with DM are at greater risk to develop severe COVID-19 disease, subsequent

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Yaqian Mao Shengli Clinical Medical College of Fujian Medical University, Fujian, China
Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Lizhen Xu Shengli Clinical Medical College of Fujian Medical University, Fujian, China

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Ting Xue Shengli Clinical Medical College of Fujian Medical University, Fujian, China

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Jixing Liang Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Wei Lin Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Junping Wen Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Huibin Huang Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Liantao Li Department of Endocrinology, Fujian Provincial Hospital, Fujian, China

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Gang Chen Shengli Clinical Medical College of Fujian Medical University, Fujian, China
Department of Endocrinology, Fujian Provincial Hospital, Fujian, China
Fujian Provincial Key Laboratory of Medical Analysis, Fujian Academy of Medical, Fujian, China

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mineral density in US older adults . Archives of Osteoporosis 2014 9 175. ( https://doi.org/10.1007/s11657-014-0175-2 ) 43 Hans D Dargent-Molina P Schott AM Sebert JL Cormier C Kotzki PO Delmas PD Pouilles JM Breart G Meunier PJ

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Alessandro Ciresi Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Stefano Radellini Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Valentina Guarnotta Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Maria Grazia Mineo Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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Carla Giordano Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy

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. Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults . Journal of Clinical Endocrinology and Metabolism 2004 89 6291

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Yunting Lin Department of Surgical Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China

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Endi Song Department of Internal Medicine, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China

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Han Jin Department of Medicine, Ningbo University, Ningbo, Zhejiang, China

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Yong Jin Department of Internal Medicine, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China

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cerebral blood flow and preserved cerebrovascular reactivity in older adults . Circulation 2018 138 1951 – 1962 . ( https://doi.org/10.1161/circulationaha.118.032410 ) 5 Ruiz-Hurtado G & Ruilope LM . Microvascular injury and the kidney in

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Shanhong Li Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu Province, China

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Jincheng Tao Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu Province, China
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China

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Jie Tang Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu Province, China

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Yanting Chu Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu Province, China

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Huiqun Wu Department of Medical Informatics, Medical School of Nantong University, Nantong, Jiangsu Province, China

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. Burden of common multiple-morbidity constellations on out-of-pocket medical expenditures among older adults. Gerontologist 2007 47 423 – 437 . ( https://doi.org/10.1093/geront/47.4.423 ) 6 Liu J Liu M Chai Z Li C Wang Y Shen M Zhuang G

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Giuseppe Grande Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Andrea Graziani Department of Medicine, University of Padova, Padova, Italy

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Antonella Di Mambro Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Riccardo Selice Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Alberto Ferlin Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
Department of Medicine, University of Padova, Padova, Italy

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sarcopenia in older-adult men: a narrative review . Journal of Clinical Medicine 2022 11 6202. ( https://doi.org/10.3390/jcm11206202 ) 97 Hassan-Smith ZK Jenkinson C Smith DJ Hernandez I Morgan SA Crabtree NJ Gittoes NJ Keevil BG Stewart

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Ewa Stogowska Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland

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Karol Adam Kamiński Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, Bialystok, Poland

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Bartosz Ziółko Techmo, Kraków, Poland

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Irina Kowalska Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland

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voice data for younger and older adults . Journal of Voice 2013 27 545 – 555 . ( https://doi.org/10.1016/j.jvoice.2013.03.002 ) 49 Xue SAXD Deliyski D . Effects of aging on selected acoustic voice parameters: preliminary normative data and

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Aliyu Tijani Jibril Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

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Ahmad Jayedi Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran

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Sakineh Shab-Bidar Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

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-Osorio E Pedraza-Chaverri J Hernández-Abad VJ . The effect of 600 mg alpha-lipoic acid supplementation on oxidative stress, inflammation, and RAGE in older adults with type 2 diabetes mellitus . Oxidative Medicine and Cellular Longevity 2019 2019

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Małgorzata Kałużna Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Pola Kompf Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Katarzyna Wachowiak-Ochmańska Heliodor Święcicki Clinical Hospital, Poznan, Poland

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Jerzy Moczko Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland

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Aleksandra Królczyk Chair and Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Adam Janicki Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Karol Szapel Department of Physiotherapy, Poznan University of Medical Sciences, Poznan, Poland

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Marian Grzymisławski Chair and Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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Katarzyna Ziemnicka Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland

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specific IBS biomarker render a IBS diagnosis challenging. Although IBS may affect all ages and sexes, younger patients present with abdominal discomfort more frequently than older adults ( 12 ), with a 25% lower IBS prevalence in the latter group ( 10

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Feifei Shao Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China
Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Xinxin Hu Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Jiayu Li Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Bona Bai Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China
Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China

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cohort studies have been performed in adults ( 20 , 21 , 22 , 23 ). Given the large number of obese older adults with T2DM, our study included only a ‘pure’ population of patients with obesity adults aged 65–70 years with NGT, IGT, and T2DM and

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