Anne H van der Spek
Anne H van der Spek
Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
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Olga V Surovtseva
Olga V Surovtseva
Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
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Saskia Aan
Saskia Aan
Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
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Anton T J Tool
Anton T J Tool
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands
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Annemarie van de Geer
Annemarie van de Geer
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands
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Korcan Demir
Korcan Demir
Division of Pediatric Endocrinology, Dokuz Eylül University, Izmir, Turkey
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Anja L M van Gucht
Anja L M van Gucht
Department of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
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A S Paul van Trotsenburg
A S Paul van Trotsenburg
Department of Pediatric Endocrinology, Academic Medical Center, Amsterdam, The Netherlands
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Timo K van den Berg
Timo K van den Berg
Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
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potentially result in increased levels of IL-8. As elevated IL-8 was observed in patients both on and off levothyroxine, it appears to be an effect of the underlying condition, not its treatment. Intracellular TH metabolism is thought to play an important
Florian W Kiefer
Florian W Kiefer
Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
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found that TSH-suppressing treatment with levothyroxine (T4) induced BAT activity and browning of subcutaneous adipose tissue ( 56 ). The relevance of thyroid hormones for adipose browning in humans is also supported by findings that circulating free T4
Marek Niedziela
Marek Niedziela
Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland
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of patients; and the genetic cause of hyperthyroidism due to THRB mutation is rare and manifests in the foetal/neonatal period only in a very severe state. Iatrogenic hyperthyroidism is caused by an overdose of levothyroxine (LT4); goitre does
Reem Al Argan
Reem Al Argan
Endocrine Section, Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Khobar, Eastern Province, Saudi Arabia
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Abdulaziz Ramadhan
Abdulaziz Ramadhan
Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
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Ramanakumar V Agnihotram
Ramanakumar V Agnihotram
Statistician, Research Institute-McGill University Health Center, Montreal, Quebec, Canada
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Jeffrey Chankowsky
Jeffrey Chankowsky
Department of Diagnostic Radiology, McGill University Health Center, Montreal, Quebec, Canada
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Juan Rivera
Juan Rivera
Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
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assessment for secondary hypothyroidism should be reassessed. Clinical evaluation, along with measurement of free T4 and TSH, will dictate the need for levothyroxine replacement. Additionally, male patients, older patients, and patients whose tumors enhance
Kinnaree Sorapipatcharoen
Kinnaree Sorapipatcharoen
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Thipwimol Tim-Aroon
Thipwimol Tim-Aroon
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Pat Mahachoklertwattana
Pat Mahachoklertwattana
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Wasun Chantratita
Wasun Chantratita
Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Nareenart Iemwimangsa
Nareenart Iemwimangsa
Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Insee Sensorn
Insee Sensorn
Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Bhakbhoom Panthan
Bhakbhoom Panthan
Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Poramate Jiaranai
Poramate Jiaranai
Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Saisuda Noojarern
Saisuda Noojarern
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Patcharin Khlairit
Patcharin Khlairit
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Sarunyu Pongratanakul
Sarunyu Pongratanakul
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Chittiwat Suprasongsin
Chittiwat Suprasongsin
Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Manassawee Korwutthikulrangsri
Manassawee Korwutthikulrangsri
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Chutintorn Sriphrapradang
Chutintorn Sriphrapradang
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Preamrudee Poomthavorn
Preamrudee Poomthavorn
Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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as having undetermined cause. Patients with persistently high TSH after levothyroxine (LT 4 ) discontinuation after 3 years of age were diagnosed as having permanent CH. ‘Transient’ CH was diagnosed based on having normal thyroid function test results
Marra Jai Aghajani
Marra Jai Aghajani
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Tara Laurine Roberts
Tara Laurine Roberts
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Tao Yang
Tao Yang
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia
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Charles Eugenio McCafferty
Charles Eugenio McCafferty
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
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Nicole J Caixeiro
Nicole J Caixeiro
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia
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Paul DeSouza
Paul DeSouza
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia
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Navin Niles
Navin Niles
Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
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patients typically involves surgical resection and suppression of thyroid-stimulating hormone (TSH) via levothyroxine, with additional consideration for adjuvant radioactive iodine (RAI) treatment to ablate residual thyroid tissue and eradicate any
Nannan Bian
Nannan Bian
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Xiaomeng Sun
Xiaomeng Sun
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Biao Zhou
Biao Zhou
Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
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Lin Zhang
Lin Zhang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Qiu Wang
Qiu Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yu An
Yu An
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Xiaohui Li
Xiaohui Li
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yinhui Li
Yinhui Li
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Hua Meng
Hua Meng
Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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disease, infectious disease, systemic inflammatory disease, mental illnesses, cancer or severe hereditary diseases were excluded. No subject took hypoglycemic drugs, antithyroid and levothyroxine drugs. We first divided the 287 participants into 3 groups
Lára Ósk Eggertsdóttir Claessen
Lára Ósk Eggertsdóttir Claessen
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Hafrún Kristjánsdóttir
Hafrún Kristjánsdóttir
Physical Activity, Physical Education, Sport, and Health (PAPESH) Research Centre, Sports Science Department, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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María Kristín Jónsdóttir
María Kristín Jónsdóttir
Mental Health Services, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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Sigrún Helga Lund
Sigrún Helga Lund
deCODE Genetics, Inc/Amgen Inc., Reykjavik, Iceland
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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Ingunn Unnsteinsdóttir Kristensen
Ingunn Unnsteinsdóttir Kristensen
Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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Helga Ágústa Sigurjónsdóttir
Helga Ágústa Sigurjónsdóttir
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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the 16 women with PD, thus 81% of women with PD needed medical treatment. All six women diagnosed with HP were started on treatment with HST (levothyroxine for central hypothyroidism n = 4, somatropin for GHD n = 2). Seven of the 10 women with HPRL
Jakub Supronik
Jakub Supronik
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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Małgorzata Szelachowska
Małgorzata Szelachowska
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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Adam Kretowski
Adam Kretowski
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Katarzyna Siewko
Katarzyna Siewko
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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mean duration of GO was 26 months (range 14–48), one patient was an active smoker , nine were ex-smokers and five never smoked. Five patients received AT combined with levothyroxine (LT), one patient received AT alone, and nine received LT alone. CAS
