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Maryam Iravani Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Solna, Sweden

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Marie K Lagerquist Center of Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Elham Karimian Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Solna, Sweden

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Andrei S Chagin Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden
Institute for Regenerative Medicine, Sechenov University, Moscow, Russian Federation

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Claes Ohlsson Center of Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Lars Sävendahl Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Solna, Sweden

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, activation of GPER1, a transmembrane ER, leads to rapid changes in the concentrations of messenger molecules and regulation of kinase pathways. Several studies have found that GPER1 is widely expressed in human tissues, such as, lungs, heart, and the immune

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0274
Volume/Issue:
Volume 8: Issue 9
Open access
Nassim Ghaffari-Tabrizi-Wizsy Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Christina Angelika Passegger Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Laura Nebel Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Fabian Krismer Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Gudrun Herzer-Schneidhofer Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Gert Schwach Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Roswitha Pfragner Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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-based assays, this technique allows detecting invasion and angiogenesis. Other advantages are the lack of immune system and the possibility to easily study therapeutic effects on tumour growth and expression of signalling molecules. A further advantage is that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0431
Volume/Issue:
Volume 8: Issue 5
Open access
Cornelia Then Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany

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Holger Then Freie Waldorfschule Augsburg, Augsburg, Germany

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Andreas Lechner Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany
German Center for Diabetes Research (DZD), München-Neuherberg, Germany

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Cornelia Huth German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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Christa Meisinger Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
Chair of Epidemiology at UNIKAT Augsburg, Ludwig-Maximilians-Universität München, Munich, Germany

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Margit Heier Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
KORA Study Center, University Hospital Augsburg, Augsburg, Germany

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Annette Peters German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

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Wolfgang Koenig DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
Deutsches Herzzentrum München, Technische Universität München, Munich, Germany

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Wolfgang Rathmann Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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Christian Herder German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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Michael Roden German Center for Diabetes Research (DZD), München-Neuherberg, Germany
Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

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Jürgen Scherberich Klinikum München-Harlaching, Teaching Hospital of the Ludwig-Maximilians-Universität, Munich, Germany

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Jochen Seissler Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munich, Germany
Clinical Cooperation Group Diabetes, LMU München and Helmholtz Zentrum München, Munich, Germany

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immunomodulatory functions ( 9 , 10 ). Whether immunomodulatory uromodulin properties also play a role in the circulation is not yet known. Nevertheless, uromodulin is capable of binding immunoglobulins and complement and to activate immune cells in experimental

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0352
Volume/Issue:
Volume 8: Issue 10
Open access
Gregory Knowles Walsall Manor Hospital, Walsall, UK

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Emily Warmington College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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Lisa M Shepherd Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Jonathan M Hazlehurst Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Applied Health Research, University of Birmingham, Birmingham, UK

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Anne de Bray Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Helena Gleeson Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Wiebke Arlt Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Medical Research Council London Institute of Medical Sciences, London, UK

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Alessandro Prete Department of Endocrinology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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from asymptomatic infection to acute respiratory distress syndrome, multiorgan failure and death. One key negative prognostic factor for severe COVID-19 is compromised immunity and increased infection risk ( 13 ); as such, patients with PAI are assumed

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-23-0122
Volume/Issue:
Volume 12: Issue 8
Open access
Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Tao Tong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Zheng Li Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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in patients with GHPA can contribute to the improvement of hyperthyroidism in GD. Several studies have confirmed the important role of GH in the pathogenesis of GD, which is involved in the immune regulation of cells by binding to receptors on the

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0439
Volume/Issue:
Volume 13: Issue 4
Open access
M L M Barreto-Chaves Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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N Senger Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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M R Fevereiro Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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A C Parletta Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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A P C Takano Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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, approximately 5% of non-myocytes are hematopoietic-derived cells ( 65 ). Additionally, resident and recruited immune cells respond earlier to cardiac injury, and coordinate cardiomyocyte and non-cardiomyocyte responses during hypertrophy and remodeling ( 66

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0543
Volume/Issue:
Volume 9: Issue 3
Open access
Shu-Meng Hu Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Yang-Juan Bai Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Ya-Mei Li Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Ye Tao Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Xian-Ding Wang Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Tao Lin Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Lan-Lan Wang Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Yun-Ying Shi Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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( 36 ) and further lead to decreased expression of the FGF23 gene. Previous in vitro studies have proven that VDR and CYP27B1 are expressed in several innate and adaptive immune cells, which enables immune cells to synthesize active vitamin D

Article Type:
Research Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-22-0123
Volume/Issue:
Volume 11: Issue 8
Open access
Kaili Yang Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Jiarui Li Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China

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Yuejuan Cheng Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Chunmei Bai Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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64 (37.6) Treatment regimen d  Drug 153 (90.0)   SSA 20 (11.8)   Targeted therapy 74 (43.5)   Immunotherapy 20 (11.8)    Immune checkpoint inhibitor 16 (9.4)    Other immune modulators 4 (2

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0441
Volume/Issue:
Volume 12: Issue 4
Open access
Monia Cito Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Silvia Pellegrini Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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Lorenzo Piemonti Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
Vita-Salute San Raffaele University, Milan, Italy

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Valeria Sordi Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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-01) were encapsulated into an immune-protecting medical device (named Encaptra drug delivery system) and transplanted in a small cohort of T1D patients. This trial aims to evaluate safety, long-term tolerability and efficacy of this system and the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0012
Volume/Issue:
Volume 7: Issue 3
Open access
T P McVeigh Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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R J Mulligan Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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U M McVeigh Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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P W Owens Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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N Miller Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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M Bell Department of Endocrinology, School of Medicine, NUI Galway, Galway, Ireland

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F Sebag Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France

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C Guerin Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France

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D S Quill Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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J B Weidhaas David Geffen School of Medicine, University of California, Los Angeles, USA

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M J Kerin Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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A J Lowery Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland

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includes two closely related but genetically distinct microRNAs, miR-146a and miR-146b, differing only at two nucleotides in the 3′ region of the mature sequences ( 17 ). These miRNAs are critical in a number of immune and inflammatory response pathways

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0196
Volume/Issue:
Volume 6: Issue 8
Open access