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M Guftar Shaikh
M Guftar Shaikh
Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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Timothy G Barrett
Timothy G Barrett
Department of Endocrinology, Birmingham Womens and Children’s Hospital, Birmingham, UK
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK
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Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK
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Nicola Bridges
Nicola Bridges
Department of Paediatric Endocrinology, Chelsea and Westminster Hospital, London, UK
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Robin Chung
Robin Chung
Research Working Group, Prader-Willi Syndrome Association, Northampton, UK
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Evelien F Gevers
Evelien F Gevers
Department of Paediatric Endocrinology, Barts Health NHS Trust, Royal London Hospital, London, UK
Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
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Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
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Anthony P Goldstone
Anthony P Goldstone
PsychoNeuroEndocrinologyResearch Group, Division of Psychiatry, Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
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Anthony Holland
Anthony Holland
Department of Psychiatry, University of Cambridge, Cambridge, UK
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Shankar Kanumakala
Shankar Kanumakala
Royal Alexandra Children’s Hospital, Brighton, UK
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Ruth Krone
Ruth Krone
Department of Endocrinology, Birmingham Womens and Children’s Hospital, Birmingham, UK
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Andreas Kyriakou
Andreas Kyriakou
Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK
Department of Paediatric Endocrinology, Makarios Children's Hospital, Nicosia, Cyprus
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Department of Paediatric Endocrinology, Makarios Children's Hospital, Nicosia, Cyprus
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E Anne Livesey
E Anne Livesey
Royal Alexandra Children’s Hospital, Brighton, UK
Sussex Community NHS Trust, Brighton, UK
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Sussex Community NHS Trust, Brighton, UK
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Angela K Lucas-Herald
Angela K Lucas-Herald
Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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Christina Meade
Christina Meade
CHI at Tallaght University Hospital, Dublin, Republic of Ireland
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Susan Passmore
Susan Passmore
Prader-Willi Syndrome Association, Northampton, UK
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Edna Roche
Edna Roche
CHI at Tallaght University Hospital, Dublin, Republic of Ireland
The University of Dublin, Trinity College Dublin, Dublin, Republic of Ireland
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The University of Dublin, Trinity College Dublin, Dublin, Republic of Ireland
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Chris Smith
Chris Smith
Royal Alexandra Children’s Hospital, Brighton, UK
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Sarita Soni
Sarita Soni
Learning Disability Psychiatry, NHS Greater Glasgow and Clyde, Glasgow, UK
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adulthood ( 5 , 6 , 7 , 8 ). CA affected by PWS can develop endocrinopathies due to hypothalamic dysfunction, such as growth hormone deficiency (GHD), and hypogonadotropic and hypergonadotropic hypogonadism. Central hypothyroidism and central adrenal
Filippo Ceccato
Filippo Ceccato
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Elisa Selmin
Elisa Selmin
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Chiara Sabbadin
Chiara Sabbadin
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Miriam Dalla Costa
Miriam Dalla Costa
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Giorgia Antonelli
Giorgia Antonelli
Laboratory Medicine, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Mario Plebani
Mario Plebani
Laboratory Medicine, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Mattia Barbot
Mattia Barbot
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Corrado Betterle
Corrado Betterle
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Marco Boscaro
Marco Boscaro
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Carla Scaroni
Carla Scaroni
Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy
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Mantero F. Concomitant therapies (glucocorticoids and sex hormones) in adult patients with growth hormone deficiency . Journal of Endocrinological Investigation 2008 31 (Supplement 9) 61 . 19020389 6 Husebye ES Allolio B Arlt W Badenhoop K
Agnieszka Bogusz
Agnieszka Bogusz
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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Svenja Boekhoff
Svenja Boekhoff
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
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Monika Warmuth-Metz
Monika Warmuth-Metz
Department of Neuroradiology, University Hospital, Würzburg, Germany
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Gabriele Calaminus
Gabriele Calaminus
Department of Pediatric Oncology and Hematology, University Hospital, Bonn, Germany
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Maria Eveslage
Maria Eveslage
Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
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XRT No XRT XRT No XRT XRT Diabetes insipidus centralis, n 43 35 3 8 11 13 29 14 0.068 0.030 Growth hormone deficiency, n 33 27 5 9 8 8 20 10 1.0 1.0 Hypothyroidism, n 41 39
K L Gatford
K L Gatford
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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G K Heinemann
G K Heinemann
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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S D Thompson
S D Thompson
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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J V Zhang
J V Zhang
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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S Buckberry
S Buckberry
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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J A Owens
J A Owens
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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G A Dekker
G A Dekker
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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C T Roberts
C T Roberts
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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on behalf of the SCOPE Consortium
on behalf of the SCOPE Consortium
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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Trygstad O Öfverholm U . Somatomedin levels in pregnancy: longitudinal study in healthy subjects and patients with growth hormone deficiency . Journal of Clinical Endocrinology and Metabolism 1984 59 587 – 594 . ( doi:10.1210/jcem-59-4-587 ). 66
Min Yang
Min Yang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Xiangling Deng
Xiangling Deng
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Shunan Wang
Shunan Wang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Bo Zhou
Bo Zhou
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Wenquan Niu
Wenquan Niu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China
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Zhixin Zhang
Zhixin Zhang
International Medical Services, China-Japan Friendship Hospital, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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.1017/s0021932003002633 ) 27 Lindsay R Feldkamp M Harris D Robertson J Rallison M Utah Growth Study: growth standards and the prevalence of growth hormone deficiency . Journal of Pediatrics 1994 125 29 – 35 . ( https://doi.org/10.1016/s
Jessica S Jarmasz
Jessica S Jarmasz
Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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Yan Jin
Yan Jin
Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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Hana Vakili
Hana Vakili
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Peter A Cattini
Peter A Cattini
Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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Wildschiødtz G Juul A Hilsted J Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss . Obesity 2008 16 1516 – 15 21 . ( https://doi.org/10.1038/oby.2008.249 ) 7 Salvatori R Growth hormone deficiency
J Van Schaik
J Van Schaik
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Burghard
M Burghard
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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M H Lequin
M H Lequin
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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E A van Maren
E A van Maren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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A M van Dijk
A M van Dijk
Department of Dietetics, University Medical Center Utrecht, Utrecht, The Netherlands
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T Takken
T Takken
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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L B Rehorst-Kleinlugtenbelt
L B Rehorst-Kleinlugtenbelt
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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B Bakker
B Bakker
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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L Meijer
L Meijer
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E W Hoving
E W Hoving
Division of Neurosurgery, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Fiocco
M Fiocco
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Institute of Mathematics, Leiden University, Leiden, The Netherlands
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Institute of Mathematics, Leiden University, Leiden, The Netherlands
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A Y N Schouten-van Meeteren
A Y N Schouten-van Meeteren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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W J E Tissing
W J E Tissing
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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H M van Santen
H M van Santen
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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, restoring the IGF-1 concentrations in children with growth hormone deficiency and aiming for low-normal hydrocortisone maintenance doses may aid to improve metabolic state ( 21 , 22 , 62 ). Our selection of patients included in this cohort may be
Christine Poitou
Christine Poitou
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris, France
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Anthony Holland
Anthony Holland
Department of Psychiatry, University of Cambridge, UK
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Charlotte Höybye
Charlotte Höybye
Department of Endocrinology and Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
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Laura C G de Graaff
Laura C G de Graaff
Center for Adults with Rare Genetic Syndromes, Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Sandrine Bottius
Sandrine Bottius
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris, France
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Berit Otterlei
Berit Otterlei
Landsforeningen for Prader-Willis Syndrom Hiltonåsen, Slependen, Norway
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Maithé Tauber
Maithé Tauber
Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service d’Endocrinologie, Obésités, Maladies Osseuses, Génétique et Gynécologie Médicale, Hôpital des Enfants, Toulouse, France
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prevented Growth hormone deficiency almost 100% in children and 50% in adults, SGA in 20% Hypogonadism mixed > 60% (adult > 90%) Cryptorchidism more than 90% Premature or agressive adrenarche 30% Hypothyroïdism 20
Rachel K Rowe
Rachel K Rowe
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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Benjamin M Rumney
Benjamin M Rumney
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Hazel G May
Hazel G May
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Paska Permana
Paska Permana
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
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P David Adelson
P David Adelson
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA
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S Mitchell Harman
S Mitchell Harman
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
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Jonathan Lifshitz
Jonathan Lifshitz
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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Theresa C Thomas
Theresa C Thomas
Phoenix Veterans Affairs Health Care System, Phoenix, Arizona, USA
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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decreased TSH levels and contributed to this weight gain. Growth hormone deficiency has also been associated with weight gain; however, weight redistribution due to altered body composition (increased fat and decreased lean body mass) more accurately
Alice Costantini
Alice Costantini
Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
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Mari H Muurinen
Mari H Muurinen
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland
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Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland
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Outi Mäkitie
Outi Mäkitie
Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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patients with cataracts, growth hormone deficiency with short stature, partial sensorineural deafness, and peripheral neuropathy or with Leigh syndrome . Human Mutation 2014 35 1285 – 1289 . ( https://doi.org/10.1002/humu.22629 ) 105 Huckert M
