Xiaojie Wang
Xiaojie Wang
Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China
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Zhiyuan Chen
Zhiyuan Chen
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Ziyi Li
Ziyi Li
Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China
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Bo Chen
Bo Chen
Department of Endocrinology, Guangdong Second Provincial General Hospital, Guangzhou, China
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Yong Qi
Yong Qi
Department of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, China
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Guowei Li
Guowei Li
Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
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Jonathan D Adachi
Jonathan D Adachi
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada
Department of Medicine, McMaster University, Hamilton, Canada
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Department of Medicine, McMaster University, Hamilton, Canada
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(e.g. fractures, severe soft tissue injuries, hospitalization, and even death) with different severity ( 2 , 3 , 4 ). The risk of fall increases with aging and those middle-aged and the older are at the highest risk of fall ( 5 ). It was estimated
Marlena Mueller
Marlena Mueller
Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
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Fahim Ebrahimi
Fahim Ebrahimi
Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland
University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital, Basel, Switzerland
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University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital, Basel, Switzerland
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Emanuel Christ
Emanuel Christ
Division of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland
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Christian Andreas Nebiker
Christian Andreas Nebiker
Department of Surgery, Kantonsspital Aarau AG, Aarau, Switzerland
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Philipp Schuetz
Philipp Schuetz
Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Faculty of Medicine, University Hospital Basel, Basel, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Faculty of Medicine, University Hospital Basel, Basel, Switzerland
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Beat Mueller
Beat Mueller
Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Faculty of Medicine, University Hospital Basel, Basel, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Faculty of Medicine, University Hospital Basel, Basel, Switzerland
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Alexander Kutz
Alexander Kutz
Division of Endocrinology, Diabetes, and Metabolism, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
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): Age <50 years, serum calcium >0.25 mmol/L above the upper limit of normal, decreased bone mineral density in dual-energy x-ray absorptiometry (T-score <−2.5 at lumbar spine, total hip, femoral neck, or distal 1/3 radius), vertebral fractures on imaging
Sharon A Huish
Sharon A Huish
University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
The University of Warwick, Coventry, UK
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
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The University of Warwick, Coventry, UK
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
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Carl Jenkinson
Carl Jenkinson
The University of Birmingham, Birmingham, UK
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Janet A Dunn
Janet A Dunn
The University of Warwick, Coventry, UK
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David J Meredith
David J Meredith
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
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Rosemary Bland
Rosemary Bland
The University of Warwick, Coventry, UK
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Martin Hewison
Martin Hewison
The University of Birmingham, Birmingham, UK
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CKD and bone disorders ( 35 , 36 , 37 ). Evidence suggests the value of using 25(OH)D:24,25(OH) 2 D in assessment and management of both fracture risk and CKD risk ( 38 , 39 ). Serum 1,25(OH) 2 D 3 is not routinely measured clinically ( 40 , 41
Rui-yi Tang
Rui-yi Tang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
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Rong Chen
Rong Chen
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
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Miao Ma
Miao Ma
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
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Shou-qing Lin
Shou-qing Lin
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
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Yi-wen Zhang
Yi-wen Zhang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
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Ya-ping Wang
Ya-ping Wang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China
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experienced BMD improvement after receiving hormone treatment. The hypoestrogenic state of these patients negatively affects the peak BMD, which leads to osteoporosis and a risk of fracture ( 16 ). An early start and adequate duration of hormonal therapy may
Johanna Öberg
Johanna Öberg
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
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Rolf Jorde
Rolf Jorde
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
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Yngve Figenschau
Yngve Figenschau
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway
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Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway
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Per Medbøe Thorsby
Per Medbøe Thorsby
Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway
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Sandra Rinne Dahl
Sandra Rinne Dahl
Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway
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Anne Winther
Anne Winther
Division of Neurosciences, Orthopedics and Rehabilitation Services, University Hospital of North Norway, Tromso, Norway
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Guri Grimnes
Guri Grimnes
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway
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Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway
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://doi.org/10.1093/ajcn/88.2.500S ) 15 Ginsberg C Katz R de Boer IH Kestenbaum BR Chonchol M Shlipak MG Sarnak MJ Hoofnagle AN Rifkin DE Garimella PS The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: the
M Cherenko
M Cherenko
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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N M Appelman-Dijkstra
N M Appelman-Dijkstra
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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A L Priego Zurita
A L Priego Zurita
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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N R Biermasz
N R Biermasz
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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O M Dekkers
O M Dekkers
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
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F A Klok
F A Klok
Department of Medicine, Division of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, Netherlands
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N Reisch
N Reisch
Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany
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A Aulinas
A Aulinas
Department of Endocrinology, Fundacio de Gestio Sanitaria Hospital de la Santa Creu i Sant Pau, IR-SantPau and CIBERER Unit 747 (ISCIII), Barcelona, Spain
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B Biagetti
B Biagetti
Department of Endocrinology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
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S Cannavo
S Cannavo
Endocrine Unit, University Hospital AOU Policlinico G. Martino, Messina, Italy
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L Canu
L Canu
University Hospital Florence Careggi, Florence, Italy
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M Detomas
M Detomas
Department of Internal Medicine, University Hospital Würzburg, Wuerzburg, Germany
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F Devuyst
F Devuyst
Department of Endocrinology, Hôpital Universitaire de Bruxelles, Hôpital Erasme, Brussels, Belgium
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H Falhammar
H Falhammar
Department of Endocrinology, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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R A Feelders
R A Feelders
Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, Netherlands
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F Ferrau
F Ferrau
Endocrine Unit, University Hospital AOU Policlinico G. Martino, Messina, Italy
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F Gatto
F Gatto
IRCCS Ospedale Policlinico San Martino, Genova, Genoa, Italy
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C Grasselli
C Grasselli
Cardiovascular Medicine Unit, AUSL-IRCCS, Reggio Emilia, Italy
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P van Houten
P van Houten
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, Netherlands
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C Hoybye
C Hoybye
Department of Endocrinology, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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A M Isidori
A M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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A Kyrilli
A Kyrilli
Department of Endocrinology, Hôpital Universitaire de Bruxelles, Hôpital Erasme, Brussels, Belgium
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P Loli
P Loli
Division of Endocrinology, San Raffaele Vita-Salute University, IRCCS San Raffaele Hospital Milan, Italy
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D Maiter
D Maiter
Department of Endocrinology, Cliniques universitaires Saint-Luc – UCLouvain, Brussels, Belgium
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E Nowak
E Nowak
Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany
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R Pivonello
R Pivonello
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia, Andrologia e Nutrizione, Università “Federico II” di Napoli, Naples, Italy
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O Ragnarsson
O Ragnarsson
Sahlgrenska Academy, Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine (O.R.), University of Gothenburg, Sweden
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R V Steenaard
R V Steenaard
Department of Internal Medicine, Máxima MC, Veldhoven, Netherlands
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N Unger
N Unger
University Hospital Essen, Department of Endocrinology, Diabetes and Metabolism, Essen, Germany
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A van de Ven
A van de Ven
Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, Netherlands
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S M Webb
S M Webb
Department of Endocrinology, Fundacio de Gestio Sanitaria Hospital de la Santa Creu i Sant Pau, IR-SantPau and CIBERER Unit 747 (ISCIII), Barcelona, Spain
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D Yeste
D Yeste
Pediatric Endocrinology Service, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. CIBER Enfermedades Raras, Instituto Carlos III, Madrid, Spain
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S F Ahmed
S F Ahmed
Department of Medicine, Division of Endocrinology, Leiden University Medical Centre, Leiden, Netherlands
University of Glasgow, Office for Rare Conditions, Glasgow, UK
University of Glasgow, Developmental Endocrinology Research Group, Royal Hospital for Children, Glasgow, UK
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University of Glasgow, Office for Rare Conditions, Glasgow, UK
University of Glasgow, Developmental Endocrinology Research Group, Royal Hospital for Children, Glasgow, UK
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A M Pereira
A M Pereira
Department of Endocrinology & Metabolism, Amsterdam University Medical Centre, Amsterdam, Noord-Holland, Netherlands
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Sex F F F M M F Age 48 55 33 54 35 39 Risk factors Overweight Hypertension Osteoporosis with fractures Obesity Hypertension Previous VTE Obesity Hypertension Repeated pituitary surgery Obesity Hypertension
Niek F Dirks
Niek F Dirks
Atalmedial Diagnostics Centre, Spaarne Gasthuis, Haarlem, The Netherlands
Department of Clinical Chemistry, Hematology and Immunology, Noordwest Ziekenhuis, Alkmaar, The Netherlands
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Department of Clinical Chemistry, Hematology and Immunology, Noordwest Ziekenhuis, Alkmaar, The Netherlands
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Etienne Cavalier
Etienne Cavalier
Department of Clinical Chemistry, University of Liège, CHU de Liège, Liège, Belgium
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Annemieke C Heijboer
Annemieke C Heijboer
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Boelelaan, Amsterdam, The Netherlands
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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generated if sufficient 25(OH)D is available. Measurement is recommended in individuals at increased risk of vitamin D deficiency and included obese individuals, pregnant and lactating women, older adults with a history of falls or fractures, individuals
Mengting Yin
Mengting Yin
Sichuan University West China Hospital, Chengdu, China
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Qianhui Liu
Qianhui Liu
Sichuan University West China Hospital, Chengdu, China
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Qingzhong Wang
Qingzhong Wang
Jintang First People’s Hospital, West China Hospital Sichuan University Jingtang Hospital, Chengdu, China
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Yong He
Yong He
Sichuan University West China Hospital, Chengdu, China
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Haolan Song
Haolan Song
Sichuan University West China Hospital, Chengdu, China
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Xin Nie
Xin Nie
Sichuan University West China Hospital, Chengdu, China
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Guixing Li
Guixing Li
Sichuan University West China Hospital, Chengdu, China
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hormone required for the maintenance of the homeostasis of calcium and phosphate, can lead to skeletal, renal, and cardiovascular complications, including hypercalcemia, hypophosphatemia, osteoporosis, fragility fractures, bone pain, nephrolithiasis
H A Booij
H A Booij
Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands
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W D C Gaykema
W D C Gaykema
Roessingh Rehabilitation Center, Enschede, the Netherlands
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K A J Kuijpers
K A J Kuijpers
Roessingh Rehabilitation Center, Enschede, the Netherlands
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M J M Pouwels
M J M Pouwels
Department of Endocrinology, Medisch Spectrum Twente, Enschede, the Netherlands
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H M den Hertog
H M den Hertog
Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands
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this finding. In a systematic review of 27 studies, increased age, TBI severity and skull fractures predicted anterior pituitary disorders in post-TBI patients ( 29 ). However, the authors only found a limited number of studies with a low risk of bias
Agnieszka Pazderska
Agnieszka Pazderska
Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
Department of Endocrinology, St James’s Hospital, Dublin, Ireland
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Department of Endocrinology, St James’s Hospital, Dublin, Ireland
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Yaasir Mamoojee
Yaasir Mamoojee
Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
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Satish Artham
Satish Artham
Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
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Margaret Miller
Margaret Miller
Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
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Stephen G Ball
Stephen G Ball
Department of Endocrinology, Central Manchester University Hospitals, Manchester, UK
Department of Endocrinology, University of Manchester, Manchester, UK
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Department of Endocrinology, University of Manchester, Manchester, UK
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Tim Cheetham
Tim Cheetham
Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK
Department of Paediatric Endocrinology & Diabetes, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
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Department of Paediatric Endocrinology & Diabetes, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
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Richard Quinton
Richard Quinton
Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK
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Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK
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course, revisit this strategy in the event of intercurrent spinal fracture for which parenteral antiresorptives may also be beneficial for pain control and bone remodelling, but have not yet faced this scenario in this group of patients. Despite
