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Alice S Ryan VA Maryland Health Care System, Division of Endocrinology, Research Service, Division of Gerontology and Geriatric Medicine, Department of Medicine, Baltimore Veterans Affairs Medical Center, 10 North Greene Street GRECC (BT/18/GR), Baltimore, Maryland 21201, USA

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John C McLenithan VA Maryland Health Care System, Division of Endocrinology, Research Service, Division of Gerontology and Geriatric Medicine, Department of Medicine, Baltimore Veterans Affairs Medical Center, 10 North Greene Street GRECC (BT/18/GR), Baltimore, Maryland 21201, USA

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Gretchen M Zietowski VA Maryland Health Care System, Division of Endocrinology, Research Service, Division of Gerontology and Geriatric Medicine, Department of Medicine, Baltimore Veterans Affairs Medical Center, 10 North Greene Street GRECC (BT/18/GR), Baltimore, Maryland 21201, USA

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Introduction Women with a history of gestational diabetes mellitus (GDM) are at an increased risk for the development of type 2 diabetes mellitus (T2DM) within 5 years following pregnancy (1, 2) with the reported incidence of T2DM ranging from

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Yun Cai Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Jieni Yan Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Yong Gu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Heng Chen Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Yang Chen Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Xinyu Xu Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Mei Zhang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Liping Yu Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Xuqin Zheng Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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’ hyperthyroidism, while TGAb and TPOAb are more characteristic for HT, which is correlated with thyroidal damage and lymphocytic inflammation ( 1 , 2 ). Individuals with AITD may be associated with other autoimmune diseases, of which type 1 diabetes mellitus (T1

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Giovanni Fanni Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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Petros Katsogiannos Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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Bipasha Nandi Jui Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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Magnus Sundbom Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Susanne Hetty Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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Maria J Pereira Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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Jan W Eriksson Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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Introduction Besides inducing significant and durable weight loss, Roux-en-Y gastric bypass (RYGB) improves glycemic control in insulin-resistant patients and can prevent or reverse type 2 diabetes mellitus (T2DM) ( 1 , 2 , 3 ). This

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Shaomin Shi Division of Nephrology, The First Affiliated Hospital of Yangtze University, Jingzhou, China

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Xinghua Chen Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China

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Wen Yu Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China

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Xiaolan Ke Division of Nephrology, The First Affiliated Hospital of Yangtze University, Jingzhou, China

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Tean Ma Division of Nephrology, The First Affiliated Hospital of Yangtze University, Jingzhou, China

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Lang Y Yang W Yang F Yang J Wu Y Xiao X Qin C Zou Y Zhao Y , Efficacy and safety of drugs for people with type 2 diabetes mellitus and chronic kidney disease on kidney and cardiovascular outcomes: a systematic review and network meta

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Bledar Daka Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden

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Thord Rosen Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden

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Per Anders Jansson Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden

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Lennart Råstam Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden

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Charlotte A Larsson Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden
Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden

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Ulf Lindblad Department of Internal Medicine, Department of Clinical Sciences Malmö, Social Medicine and Global Health, University of Gothenburg, PO Box 454, SE-405 30 Gothenburg, Sweden

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−82 °C. In participants without known diabetes mellitus, an oral glucose tolerance test (OGTT) was performed to characterize the participants with impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus according to WHO criteria

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Beibei Zhu School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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Yan Han School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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Fen Deng School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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Kun Huang School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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Shuangqin Yan Ma’anshan Maternal and Child Health Care Center, Ma’anshan, Anhui, China

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Jiahu Hao School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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Peng Zhu School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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Fangbiao Tao School of Public Health, Anhui Medical University, Hefei, Anhui, China
Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, Anhui, China
NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, China
Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Hefei, Anhui, China

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diagnosed as gestational diabetes mellitus (GDM) is a highly prevalent complication during pregnancy and affects around 15–20% of pregnancies ( 4 ) and the world has been witnessing a rapid increase in GDM incidence ( 5 ). Its negative health consequences

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Yu Ah Hong Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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Kyung-Do Han Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea

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Jae-Seung Yun Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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Eun Sil Sil Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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Seung-Hyun Ko Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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Sungjin Chung Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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Introduction Diabetic nephropathy is a major microvascular complication of type 2 diabetes mellitus (DM), and in many countries of the world, it is the major cause of end-stage renal disease (ESRD) ( 1 , 2 , 3 ). Identification of high

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Yu Lin State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Yingying Zhang State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Lei Xu Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China

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Wei Long State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Chunjian Shan State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Hongjuan Ding State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Lianghui You State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Chun Zhao State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Zhonghua Shi State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Y et al . Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus . Gut 2018 67 1614 – 1625 . ( https://doi.org/10.1136/gutjnl-2018-315988 ) 36 Huo L Lyons J Magliano DJ Infectious and environmental

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Clarissa Souza Barthem Laboratório de Adaptações Metabólicas, Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Camila Lüdke Rossetti Laboratório de Adaptações Metabólicas, Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Denise P Carvalho Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Wagner Seixas da-Silva Laboratório de Adaptações Metabólicas, Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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has become one of the most prescribed antidiabetic drugs worldwide. Although the mechanism of action of metformin is not fully understood ( 10 ), metformin is widely used for the treatment of metabolic disorders found in type 2 diabetes mellitus

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Sarantis Livadas Endocrine Unit, Athens Medical Centre, Athens, Greece

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Christina Bothou Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital of Zurich, Zurich, Switzerland

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Justyna Kuliczkowska-Płaksej Department of Endocrinology, Diabetology and Isotope Therapy, University of Medicine, Wrocław, Poland

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Ralitsa Robeva Ushate ‘acad. IV. Penchev’, Department of Endocrinology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria

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Andromahi Vryonidou Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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Jelica Bjekic Macut Department of Endocrinology, UMC Bežanijska Kosa, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Ioannis Androulakis Endocrine Unit, Athens Medical Centre, Athens, Greece

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Milica Opalic Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Zadalla Mouslech 1st Medical Propedeutic, Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Andrej Milewicz Department of Endocrinology, Diabetology and Isotope Therapy, University of Medicine, Wrocław, Poland

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Alessandra Gambineri Department of Medical and Surgical Science-DIMEC Endocrinology Unit, University of Bologna – S. Orsola-Mapighi Hospital, Italy

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Dimitrios Panidis Gynaecological Endocrinology Infirmary of the Second Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Djuro Macut Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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, accompanied by oligomenorrhea, dominate the clinical picture followed by metabolic disorders including dysglycemia and dyslipidemia later in life ( 1 ). Moreover, progression of normoglycemia to either intermediate hyperglycemia or diabetes mellitus (T2DM) has

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