Anna C Simcocks
Anna C Simcocks
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
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Kayte A Jenkin
Kayte A Jenkin
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
School of Science and Health, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Science and Health, Western Sydney University, Campbelltown, New South Wales, Australia
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Lannie O’Keefe
Lannie O’Keefe
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
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Chrishan S Samuel
Chrishan S Samuel
Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia
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Michael L Mathai
Michael L Mathai
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Victoria, Australia
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The Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Victoria, Australia
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Andrew J McAinch
Andrew J McAinch
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
Australian Institute for Musculoskeletal Science (AIMSS), College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia
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Australian Institute for Musculoskeletal Science (AIMSS), College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia
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Deanne H Hryciw
Deanne H Hryciw
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
School of Environment and Sciences, Griffith University, Nathan, Queensland, Australia
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School of Environment and Sciences, Griffith University, Nathan, Queensland, Australia
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, liver and adipose tissue fat pads were then removed postmortem, weighed individually and then the tissues were stored at −80°C for further analysis. Physiological measurements Body weight and food consumption of the rats were recorded daily
Peter Wolf
Peter Wolf
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Yvonne Winhofer
Yvonne Winhofer
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Martin Krššák
Martin Krššák
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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Michael Krebs
Michael Krebs
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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the decline in plasma FA after pharmacological inhibition of adipose tissue lipolysis was accompanied by an approximate 50% decrease of MYCL content in young, lean, insulin sensitive subjects ( 14 ). These changes in intracellular lipid stores are
Ying-Lien Cheng
Ying-Lien Cheng
Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
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Ting-I Lee
Ting-I Lee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Yu-Mei Chien
Yu-Mei Chien
Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
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Ting-Wei Lee
Ting-Wei Lee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Yi-Jen Chen
Yi-Jen Chen
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Cardiovascular Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
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Cardiovascular Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
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hyperlipidemia. Potential mechanisms of vitamin D on lipids Several possible mechanisms may explain how vitamin D affects lipid metabolism. Adipose tissue is the main site for vitamin D storage ( 27 ), and obesity was associated with a high prevalence of
Panagiotis Anagnostis
Panagiotis Anagnostis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Irene Lambrinoudaki
Irene Lambrinoudaki
2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
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John C Stevenson
John C Stevenson
National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
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Dimitrios G Goulis
Dimitrios G Goulis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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hypertrophy of adipocyte cells both in subcutaneous and visceral adipose tissue, as well as increased inflammation and fibrosis, compared with premenopausal women ( 9 ). One mechanism for the postmenopausal body fat redistribution may be the upregulation of
Feifei Cheng
Feifei Cheng
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Noel Yat Hey Ng
Noel Yat Hey Ng
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Claudia Ha Ting Tam
Claudia Ha Ting Tam
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Yuying Zhang
Yuying Zhang
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Cadmon King Poo Lim
Cadmon King Poo Lim
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Guozhi Jiang
Guozhi Jiang
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Alex Chi Wai Ng
Alex Chi Wai Ng
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Tiffany Tse Ling Yau
Tiffany Tse Ling Yau
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Lai Ping Cheung
Lai Ping Cheung
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Aimin Xu
Aimin Xu
Department of Medicine, Li Ka Shing (LKS) Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong
State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong
Department of Pharmacy and Pharmacology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong
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State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong
Department of Pharmacy and Pharmacology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong
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Juliana C N Chan
Juliana C N Chan
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong
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Ronald C W Ma
Ronald C W Ma
Department of Medicine and Therapeutics The Chinese University of Hong Kong, Hong Kong, Hong Kong
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong
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beneficial effects on metabolism, insulin sensitivity and lipid homoeostasis in animal models. Increased FGF21 levels under metabolic stresses may result from increased circulating free-fatty acids and insulin ( 24 ). Moreover, adipose tissue inflammation in
Elisabet Einarsdottir
Elisabet Einarsdottir
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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Minna Pekkinen
Minna Pekkinen
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Kaarel Krjutškov
Kaarel Krjutškov
Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland
Competence Centre on Health Technologies, Tartu, Estonia
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Competence Centre on Health Technologies, Tartu, Estonia
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Shintaro Katayama
Shintaro Katayama
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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Juha Kere
Juha Kere
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
School of Basic and Medical Biosciences, King’s College London, Guy’s Hospital, London, United Kingdom
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Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
School of Basic and Medical Biosciences, King’s College London, Guy’s Hospital, London, United Kingdom
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Outi Mäkitie
Outi Mäkitie
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
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Heli Viljakainen
Heli Viljakainen
Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
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Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
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Introduction Obesity and vitamin D deficiency represent frequent nutrition concerns worldwide and recent evidence links these together ( 1 , 2 , 3 ). Moreover, obesity and excess adipose tissue gain are suggested as a cause of vitamin D
Jay Toulany
Jay Toulany
College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
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Sebastian D Parlee
Sebastian D Parlee
Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
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Christopher J Sinal
Christopher J Sinal
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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Kathryn Slayter
Kathryn Slayter
Canadian Centre for Vaccinology, IWK Health Centre, Nova Scotia Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
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Shelly McNeil
Shelly McNeil
Canadian Centre for Vaccinology, IWK Health Centre, Nova Scotia Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
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Kerry B Goralski
Kerry B Goralski
College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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support adipose tissue/adipocytes as a significant and modifiable source of circulating total chemerin (pro and active chemerin) ( 14 , 18 , 19 , 23 , 24 , 25 , 26 , 27 ). The exact role, beneficial or detrimental, that chemerin plays in obesity is
Davoud Jafari-Gharabaghlou
Davoud Jafari-Gharabaghlou
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Mostafa Vaghari-Tabari
Mostafa Vaghari-Tabari
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Hajar Oghbaei
Hajar Oghbaei
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
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Laura Lotz
Laura Lotz
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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Reza Zarezadeh
Reza Zarezadeh
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Yeganeh Rastgar Rezaei
Yeganeh Rastgar Rezaei
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Mahnaz Ranjkesh
Mahnaz Ranjkesh
Medical Radiation Science Research Group (MRSRG), Tabriz University of Medical Sciences, Tabriz, Iran
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Mohammad Nouri
Mohammad Nouri
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Amir Fattahi
Amir Fattahi
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Saba Nikanfar
Saba Nikanfar
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Ralf Dittrich
Ralf Dittrich
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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have a role in cellular adhesion (e.g. integrins, selectins, and cadherins) ( 2 , 3 ). It has been documented that adipose tissue-derived factors can also affect implantation ( 6 , 7 ). Adipose tissue acts as an endocrine tissue and secretes hormone
Laurent Maïmoun
Laurent Maïmoun
Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHU) Montpellier, Montpellier, France
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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Denis Mariano-Goulart
Denis Mariano-Goulart
Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHU) Montpellier, Montpellier, France
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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Helena Huguet
Helena Huguet
Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Eric Renard
Eric Renard
Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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Patrick Lefebvre
Patrick Lefebvre
Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
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Marie-Christine Picot
Marie-Christine Picot
Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Anne-Marie Dupuy
Anne-Marie Dupuy
Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Jean-Paul Cristol
Jean-Paul Cristol
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Philippe Courtet
Philippe Courtet
Institut de Génomique Fonctionnelle, CNRS, INSERM Université Montpellier, Montpellier, France
Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Vincent Boudousq
Vincent Boudousq
Département de Médecine Nucléaire, Hôpital Carémeau, CHU Nîmes, Nîmes, France
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Antoine Avignon
Antoine Avignon
Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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Sébastien Guillaume
Sébastien Guillaume
Institut de Génomique Fonctionnelle, CNRS, INSERM Université Montpellier, Montpellier, France
Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Ariane Sultan
Ariane Sultan
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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, biochemical and metabolic connections between the two tissues have more recently been demonstrated ( 20 ). Thus, skeletal muscle can be classified as an endocrine organ that regulates target organs, including pancreas, liver and adipose tissue ( 21 ), through
Cheryl M Isherwood
Cheryl M Isherwood
Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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M Denise Robertson
M Denise Robertson
Section of Metabolic Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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Debra J Skene
Debra J Skene
Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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Jonathan D Johnston
Jonathan D Johnston
Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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morning clock gene expression has been reported in peripheral leukocytes of T2D patients compared to weight-matched controls ( 24 ). Moreover, a study of abdominal adipose tissue reported a reduction in the number of rhythmic genes in the abdominal adipose
