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Britt J van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F Hartmann, Johannes B van Goudoever, Stefan A Wudy, Joost Rotteveel, and Martijn J J Finken

/kg/day). Outcomes were: (1) cortisol excretion rate (µg/kg/day), (2) the sum of all glucocorticoid metabolites or corticosteroid excretion rate (µg/kg/day), and (3) the ratio of 11-hydroxy (11-OH)/11-oxoandrostenedione (11-OXO) metabolites, as an estimate of 11B

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Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen, and Geoffrey L Hammond

Introduction Corticosteroid-binding globulin (CBG) transports steroids in the blood and regulates their access to tissues and cells ( 1 , 2 ). Crystal structure analyses show that CBG contains a single hydrophobic steroid-binding site ( 3

Open access

Gavin P Vinson and Caroline H Brennan

(the therapeutic corticosteroid of choice at the time) was soon applied in the management of meperidine and morphine withdrawal symptoms in men (5) , apparently with beneficial effects, while Lovell associated alcoholism and drug addiction with

Open access

Trevor Lewis, Eva Zeisig, and Jamie E Gaida

and associated metabolic conditions, such as insulin resistance ( 5 ), diabetes ( 6 ), hypercholesterolaemia ( 7 ), statins ( 8 ), abdominal fat ( 9 ), the sympathetic nervous system ( 10 , 11 ), and corticosteroid use ( 12 ). Glucocorticoids are a

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Kamran Iqbal, Kate Halsby, Robert D Murray, Paul V Carroll, and Robert Petermann

information is well recorded and accurate ( 13 , 14 ). Study population The population of interest comprised patients with treated AI defined as an AI-specific Read code and at least one Multilex code for the corticosteroids of interest (i.e. IR HC

Open access

Stephanie E Baldeweg, Mark Vanderpump, Will Drake, Narendra Reddy, Andrew Markey, Gordon T Plant, Michael Powell, Saurabh Sinha, John Wass, and the Society for Endocrinology Clinical Committee

emergencies. Prompt resuscitation and corticosteroid replacement may be lifesaving. MRI scan is the investigation of choice. Urgent discussion with the regional neurosurgical/endocrine team is essential. Surgical intervention should be considered in

Open access

Marcus Quinkler, Bertil Ekman, Claudio Marelli, Sharif Uddin, Pierre Zelissen, Robert D Murray, and on behalf of the EU-AIR Investigators

development of corticosteroid side effects between patients ( 7 ). Interestingly, when the endogenous glucocorticoid, cortisol (hydrocortisone), is compared with prednisolone at the isolated human glucocorticoid receptor (GR), the transactivation activity of

Open access

Greta B Raglan, Louis A Schmidt, and Jay Schulkin

as a possible intervention for mental illness including depression. Although further study is necessary, it appears that corticosteroid synthesis inhibitors (CSIs) may show some efficacy in treating individuals with intractable depression ( 23

Open access

Bliss Anderson and Daniel L Morganstein

practice is to reserve high dose corticosteroids for those presenting with adrenal crisis or with significant pituitary enlargement. Other patients can be commenced directly on replacement doses of corticosteroids (e.g. hydrocortisone 20 mg daily in divided

Open access

L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran, and N F Taylor

cortisol due to rapid conversion by CYP3A4 in the liver, perhaps during a first pass after adsorption from the gut. A second factor may be an increase in corticosteroid binding globulin during mitotane treatment (23) . Induction of CYP3A4 by mitotane needs