Background Acute inflammation is typically associated with an activation of the hypothalamo-pituitary-adrenal (HPA) axis, which results in an increase in the level of glucocorticoids within the circulation ( 1 ). In situations where this
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Role of 11β-HSD type 1 in abnormal HPA axis activity during immune-mediated arthritis
Janko Sattler, Jinwen Tu, Shihani Stoner, Jingbao Li, Frank Buttgereit, Markus J Seibel, Hong Zhou, and Mark S Cooper
Low-dose short synacthen test with salivary cortisol in patients with suspected central adrenal insufficiency
Filippo Ceccato, Elisa Selmin, Giorgia Antonelli, Mattia Barbot, Andrea Daniele, Marco Boscaro, Mario Plebani, and Carla Scaroni
only confirm central AI in patients with very low morning basal serum F levels (≤83 nmol/L, 3 µg/dL), whereas only high serum F levels (≥415 nmol/L) can confirm a normal hypothalamic–pituitary–adrenal (HPA) axis ( 2 ). A confirmatory dynamic test is
Gender difference in adrenal sensitivity to ACTH is abolished in type 2 diabetes
Lisa Arnetz, Neda Rajamand Ekberg, Kerstin Brismar, and Michael Alvarsson
–pituitary–adrenal (HPA) axis, studies have shown discrepant results, reporting both increased and decreased activation (2) . Cortisol has effects opposite to those of insulin on glucose metabolism, decreasing glucose uptake and increasing gluconeogenesis (1, 2, 3
Sex-specific differences in HPA axis activity in VLBW preterm newborns
Britt J van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F Hartmann, Johannes B van Goudoever, Stefan A Wudy, Joost Rotteveel, and Martijn J J Finken
) handicaps and had lower scores on tests of neurodevelopment than their female counterparts ( 5 , 6 ). Integrity of the hypothalamic–pituitary–adrenal (HPA) axis is crucial during critical illnesses. Among preterm infants, the HPA axis seems to be
Comparison of different predominant lesions in intracranial bifocal germ cell tumors to predict neuroendocrine outcomes
Dan Liang, Han Chen, and Li-Yong Zhong
–pituitary–adrenal axis (HPA): basal cortisol level <3 μg/dL indicated impaired HPA function while the basal cortisol level >15 μg/dL excluded it. If basal cortisol levels ranged from 3 to 15 μg/dL, the circadian rhythm of adrenocorticotropic hormone and cortisol (08
Systemic effects of intratympanic dexamethasone therapy
Eva Novoa, Marcel Gärtner, and Christoph Henzen
route of administration, the varied systemic side effects of oral or intravenous glucocorticoids should be minimized, in particular the suppression of the hypothalamic–pituitary–adrenal (HPA) axis or the inhibition of osteoblast function. Even after
Predictive factors for delayed hyponatremia after transsphenoidal surgery in patients with pituitary adenomas
Kunzhe Lin, Lingling Lu, Zhijie Pei, Shuwen Mu, Shaokuan Huang, and Shousen Wang
postoperatively. Preoperative routine examination of the hypothalamus–pituitary–adrenal (HPA) axis and hypothalamus–pituitary–thyroid (HPT) axis functions was performed to determine the low function and the need for oral glucocorticoid and thyroxine replacement
Approach to patients with pseudo-Cushing’s states
Carla Scaroni, Nora M Albiger, Serena Palmieri, Davide Iacuaniello, Chiara Graziadio, Luca Damiani, Marialuisa Zilio, Antonio Stigliano, Annamaria Colao, Rosario Pivonello, and the Altogether to Beat Cushing’s Syndrome (ABC) study group
Introduction Physiological activation of the hypothalamic-pituitary-adrenal (HPA) axis can be found in several situations, such as major surgery, severe illness, intensive physical exercise, and prolonged fasting leading to improve the ability
Intraoperative low field MRI in transsphenoidal pituitary surgery
Morten Winkler Møller, Marianne Skovsager Andersen, Christian Bonde Pedersen, Bjarne Winther Kristensen, and Frantz Rom Poulsen
–pituitary–adrenal (HPA) axis (s-ACTH, s-cortisol and Synacthen test). Deficiency in either axis was defined as biochemical data outside reference values for the specific hormone or if patients were already on substitution therapy. Intact function was defined as hormone
Addiction and the adrenal cortex
Gavin P Vinson and Caroline H Brennan
also in protection against it. The hypophyseal–pituitary–adrenal axis in the brain and addiction In relation to addiction, far more attention has been paid to hypophyseal–pituitary–adrenal (HPA) components in the brain than to the systemic (i.e. blood
