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- Abstract: Hypoparathyroidism x
- Abstract: Osteo* x
- Hormones and Cancer x
Anna Gorbacheva
Anna Gorbacheva
Endocrinology Research Center, Moscow, Russian Federation
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Anna Eremkina
Anna Eremkina
Endocrinology Research Center, Moscow, Russian Federation
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Daria Goliusova
Daria Goliusova
Endocrinology Research Center, Moscow, Russian Federation
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Julia Krupinova
Julia Krupinova
Endocrinology Research Center, Moscow, Russian Federation
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Natalia Mokrysheva
Natalia Mokrysheva
Endocrinology Research Center, Moscow, Russian Federation
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Multiple endocrine neoplasia type 1 (MEN1) is the most common cause of hereditary primary hyperparathyroidism (PHPT). Bone disorders are considered one of the key symptoms in PHPT present with the significant reduction in bone mineral density and low-energy fractures. Previously, these bone disorders were believed to be caused solely by the increase in the level of parathyroid hormone and its subsequent effect on bone resorption. The current paradigm, however, states that the mutations in the menin gene, which cause the development of MEN1, can also affect the metabolism of the cells of the osteoid lineage. This review analyzes both the proven and the potential intracellular mechanisms through which menin can affect bone metabolism.
