Background: Accumulating data have shown that Interleukin-27 (IL-27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single nucleotide polymorphisms (SNPs) of IL-27 gene and autoimmune thyroid diseases (AITDs).
Methods: Three SNPs (rs153109, rs17855750 and rs181206) of IL-27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 GD and 327 HT) and 677 healthy controls in Chinese Han population.
Results: Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P=0.002 and P=0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P=0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.
Conclusion: Our study, for the first time, showed the significant association of the IL-27 gene SNPs with AITD.