Search Results

You are looking at 1 - 3 of 3 items for

  • Author: Ling Hu x
Clear All Modify Search
Ling Hu Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Search for other papers by Ling Hu in
Google Scholar
PubMed
Close
,
Ting Li Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Search for other papers by Ting Li in
Google Scholar
PubMed
Close
,
Xiao-Ling Yin Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Search for other papers by Xiao-Ling Yin in
Google Scholar
PubMed
Close
, and
Yi Zou Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Search for other papers by Yi Zou in
Google Scholar
PubMed
Close

Objective:

The purpose of this study was to explore the prevalence of thyroid nodules (TN) and metabolic syndrome (MS) and to analyze the correlation between TN and the components of MS.

Methods:

A total of 1526 subjects were divided into two groups: a TN group and a non-thyroid nodules (NTN) group. The height, weight, blood pressure, fasting blood glucose level, fasting plasma insulin level, serum lipid profile, uric acid level, serum thyroid-stimulating hormone (TSH) level, free triiodothyronine (FT3) level, and free thyroxine (FT4) level of each patient were measured. Insulin resistance (IR) was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). Fatty liver and TN were detected by color Doppler ultrasonography.

Results:

(i) The overall prevalence of TN was 39.5%; it was significantly higher in women than in men (P < 0.01) and progressively increased with age in both sexes. (ii) The overall prevalence of MS was 25.6%; it was significantly higher in men than in women (P < 0.01) and progressively increased with age in both sexes. (iii) FT3 was significantly lower in the TN group than in the NTN group (P < 0.01). (iv) BMI, triglycerides, and HOMA-IR were higher in the TN group than in the NTN group (P < 0.05). (v) The existence of TN was significantly associated with overweight/obesity (OR = 1.03, 95% CI = 1.024–1.089), and with insulin resistance (IR) (OR = 1.98, 95% CI = 1.645–2.368), after adjusting for age and sex.

Conclusions:

The prevalence of thyroid nodules and metabolic syndrome in the Nanchang area increases with age, and overweight/obesity and IR in patients are associated with thyroid nodules.

Open access
Xingrong Tan Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

Search for other papers by Xingrong Tan in
Google Scholar
PubMed
Close
,
Wenjing Hu Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing, China

Search for other papers by Wenjing Hu in
Google Scholar
PubMed
Close
,
Shan Yang Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

Search for other papers by Shan Yang in
Google Scholar
PubMed
Close
,
Han Dai Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

Search for other papers by Han Dai in
Google Scholar
PubMed
Close
,
Shangcheng Xu Chongqing Prevention and Treatment Hospital for Occupational Diseases, Chongqing, China

Search for other papers by Shangcheng Xu in
Google Scholar
PubMed
Close
,
Gangyi Yang Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

Search for other papers by Gangyi Yang in
Google Scholar
PubMed
Close
,
Ling Li Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

Search for other papers by Ling Li in
Google Scholar
PubMed
Close
,
Shiguo Tang Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

Search for other papers by Shiguo Tang in
Google Scholar
PubMed
Close
, and
Yi Wang Department of Endocrinology, 9th People’s Hospital of Chongqing, Beibei City, Chongqong, China

Search for other papers by Yi Wang in
Google Scholar
PubMed
Close

Background

The purpose of this study was to investigate the relationship between circulating zinc α 2-glycoprotein (ZAG), irisin, betatrophin and adiponectin concentrations and metabolic syndrome (MetS) components and to analyze the effects of blood glucose and insulin on these cytokine concentrations in vivo.

Methods

A total of 196 young women, including 78 healthy women and 118 women with MetS components, were recruited for this cross-sectional study. An oral glucose tolerance test and euglycemic-hyperinsulinemic clamp (EHC) were performed in healthy subjects and women with MetS components. An ELISA kit was used to measure serum ZAG, irisin, betatrophin, and adiponectin levels, and their relationship with the MetS components was analyzed.

Results

In women with MetS components, circulating irisin and betatrophin levels were significantly higher than those in the healthy women ((207 (150–248) vs 178 (147–228); P < 0.05) for irisin; (0.51 (0.38–0.63) vs 0.38 (0.23–0.52); P < 0.001) for betatrophin), but circulating ZAG and adiponectin levels were significantly lower (39.8 (26.4–50.4) vs (46.7 (40.6–63.0); P < 0.001) for ZAG; (36.5 (22.0–47.6) vs 41.2 (35.7–54.7); P < 0.01) for adiponectin). FBG, WC, and triglyceride were significantly correlated with the circulating levels of these four cytokines (P < 0.001 or <0.05). All four cytokines were associated with MetS and its components. In response to increasing insulin levels, circulating ZAG concentrations were markedly increased in both healthy subjects and women with MetS components during the EHC. However, serum irisin, betatrophin, and adiponectin levels in both healthy subjects and women with MetS components were significantly reduced compared with baseline.

Conclusion

Serum ZAG, irisin, betatrophin and adiponectin were associated with MetS and might be biomarkers for screening MetS components.

Open access
Zeming Liu Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Zeming Liu in
Google Scholar
PubMed
Close
,
Di Hu Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Di Hu in
Google Scholar
PubMed
Close
,
Yihui Huang Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Yihui Huang in
Google Scholar
PubMed
Close
,
Sichao Chen Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Sichao Chen in
Google Scholar
PubMed
Close
,
Wen Zeng Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Wen Zeng in
Google Scholar
PubMed
Close
,
Ling Zhou Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Ling Zhou in
Google Scholar
PubMed
Close
,
Wei Zhou Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Wei Zhou in
Google Scholar
PubMed
Close
,
Min Wang Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Min Wang in
Google Scholar
PubMed
Close
,
Haifeng Feng Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Haifeng Feng in
Google Scholar
PubMed
Close
,
Wei Wei Department of Pediatrics, St John Hospital and Medical Center, Detroit, Michigan, USA

Search for other papers by Wei Wei in
Google Scholar
PubMed
Close
,
Chao Zhang Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Search for other papers by Chao Zhang in
Google Scholar
PubMed
Close
,
Danyang Chen Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Danyang Chen in
Google Scholar
PubMed
Close
, and
Liang Guo Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China

Search for other papers by Liang Guo in
Google Scholar
PubMed
Close

Objectives

Controversies regarding factors associated with distant metastasis in pediatric thyroid cancer remain among the scientific community. The aim of this study was to investigate factors influencing distant metastasis in pediatric thyroid cancer.

Methods

We reviewed 1376 patients (aged 2 to 18 years) with thyroid cancer treated between 2003 and 2014. Data collected and analyzed included sex, race, age at diagnosis, year of diagnosis, pathological type, number of tumor foci, tumor extension, T-stage, N-stage, surgical procedure and radiation. Univariate and multivariate analyses were conducted to evaluate factors influencing distant metastasis of pediatric thyroid cancer.

Results

In the univariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P < 0.001), N-stage (P < 0.001), number of tumor foci (P = 0.003), tumor extension (P < 0.001) and T-stage (T1 vs T2 (P = 0.803), T3 (P < 0.001) and T4 (P < 0.001)). In multivariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P = 0.001), N-stage (P < 0.001) and T-stage (T1 vs T3 (P = 0.036) and T4 (P < 0.001)). Sex, race, year of diagnosis, pathological type, number of tumor foci, tumor extension, surgical procedure and radiation had no significant influence on distant metastasis (all P > 0.05). Furthermore, according to chi-squared test, younger pediatric thyroid cancer patients with higher T- and N-stages are more likely to have distant metastasis.

Conclusion

Age at diagnosis, T-stage and N-stage influence distant metastasis of thyroid cancer patients aged 2 to 18 years; accordingly, more radical treatments may need to be used for patients with those risk elements.

Open access