Search Results
Search for other papers by Natércia Neves Marques de Queiroz in
Google Scholar
PubMed
Search for other papers by Franciane Trindade Cunha de Melo in
Google Scholar
PubMed
Search for other papers by Fabrício de Souza Resende in
Google Scholar
PubMed
Search for other papers by Luísa Corrêa Janaú in
Google Scholar
PubMed
Search for other papers by Norberto Jorge Kzan de Souza Neto in
Google Scholar
PubMed
Search for other papers by Manuela Nascimento de Lemos in
Google Scholar
PubMed
Search for other papers by Ana Carolina Lobato Virgolino in
Google Scholar
PubMed
Search for other papers by Maria Clara Neres Iunes de Oliveira in
Google Scholar
PubMed
Search for other papers by Angélica Leite de Alcântara in
Google Scholar
PubMed
Search for other papers by Lorena Vilhena de Moraes in
Google Scholar
PubMed
Search for other papers by Tiago Franco David in
Google Scholar
PubMed
Search for other papers by Wanderson Maia da Silva in
Google Scholar
PubMed
Search for other papers by Scarlatt Souza Reis in
Google Scholar
PubMed
Search for other papers by Márcia Costa dos Santos in
Google Scholar
PubMed
Search for other papers by Ana Carolina Contente Braga de Souza in
Google Scholar
PubMed
Search for other papers by Pedro Paulo Freire Piani in
Google Scholar
PubMed
Search for other papers by Neyla Arroyo Lara Mourão in
Google Scholar
PubMed
Search for other papers by Karem Mileo Felício in
Google Scholar
PubMed
Search for other papers by João Felício Abrahão Neto in
Google Scholar
PubMed
Search for other papers by João Soares Felício in
Google Scholar
PubMed
Objective:
Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study.
Methods:
Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria.
Results:
25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL.
Conclusion:
Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.
