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  • Author: Jing Zhang x
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Open access

Weiwei He, Bin Wang, Kaida Mu, Jing Zhang, Yanping Yang, Wei Yao, Sheli Li and Jin-An Zhang

Background: Accumulating data have shown that Interleukin-27 (IL-27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single nucleotide polymorphisms (SNPs) of IL-27 gene and autoimmune thyroid diseases (AITDs).

Methods: Three SNPs (rs153109, rs17855750 and rs181206) of IL-27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 GD and 327 HT) and 677 healthy controls in Chinese Han population.

Results: Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P=0.002 and P=0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P=0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.

Conclusion: Our study, for the first time, showed the significant association of the IL-27 gene SNPs with AITD.

Open access

Jing Wang, Leishen Wang, Huikun Liu, Shuang Zhang, Junhong Leng, Weiqin Li, Tao Zhang, Nan Li, Wei Li, Andrea A Baccarelli, Lifang Hou and Gang Hu

Previous studies found conflicting results about the associations between the exposure to hyperglycemia in utero and the later risks of childhood overweight and obesity. The aim of the present study is to compare the children’s BMI growth between offspring exposed to maternal gestational diabetes mellitus (GDM) and those not exposed and assess the associations between maternal GDM and their offspring’s overweight and obesity risk. We performed a large observational study in 1156 women and their offspring (578 GDM and 578 non-GDM mother–child pairs, matched by their offspring’s gender and age). Maternal GDM was diagnosed according to the World Health Organization criteria. Childhood height, weight, waist circumference, body fat and skinfold were measured using standardized methods. After adjustment for maternal and children’s characteristics, children born to mothers with GDM during pregnancy had higher mean values of Z scores for BMI-for-age, Z scores for weight-for-age, waist circumferences, body fat, subscapular skinfold and suprailiac skinfold, in comparison with their counterparts born to mothers with normal glucose during pregnancy (all P values <0.05). Moreover, maternal GDM was associated with a higher risk of childhood overweight and obesity with multivariate-adjusted odds ratios of 1.42 (95% confidence interval (CI): 1.02–1.97) and 1.18 (95% CI: 1.11–1.24), respectively, compared with the children of mothers without GDM during pregnancy. This study demonstrates that maternal GDM is an independent risk factor of childhood overweight and obesity and is associated with higher BMI in the offspring.