Search Results
Department of Endocrinology, Zunyi Medical University, Zunyi, China
Search for other papers by Mengxue Yang in
Google Scholar
PubMed
Search for other papers by Bowen Sun in
Google Scholar
PubMed
Search for other papers by Jianhui Li in
Google Scholar
PubMed
Search for other papers by Bo Yang in
Google Scholar
PubMed
Search for other papers by Jie Xu in
Google Scholar
PubMed
Search for other papers by Xue Zhou in
Google Scholar
PubMed
Search for other papers by Jie Yu in
Google Scholar
PubMed
Search for other papers by Xuan Zhang in
Google Scholar
PubMed
Search for other papers by Qun Zhang in
Google Scholar
PubMed
Search for other papers by Shan Zhou in
Google Scholar
PubMed
Search for other papers by Xiaohua Sun in
Google Scholar
PubMed
Objectives
The pathogenesis of Graves’ disease (GD) remains unclear. In terms of environmental factors, GD development may be associated with chronic inflammation caused by alteration of the intestinal flora. This study explored the association of intestinal flora alteration with the development of GD among the Han population in southwest China.
Design and methods
Fifteen GD patients at the Affiliated Hospital of Zunyi Medical College between March 2016 and March 2017 were randomly enrolled. Additionally, 15 sex- and age-matched healthy volunteers were selected as the control group during the same period. Fresh stool samples were collected, and bacterial 16S RNA was extracted and amplified for gene sequencing with the Illumina MiSeq platform. The sequencing results were subjected to operational taxonomic unit-based classification, classification verification, alpha diversity analysis, taxonomic composition analysis and partial least squares-discriminant analysis (PLS-DA).
Results
The diversity indices for the GD group were lower than those for the control group. The GD group showed significantly higher abundances of Firmicutes, Proteobacteria and Actinobacillus and a higher Firmicutes/Bacteroidetes ratio than the control group. PLS-DA suggested the satisfactory classification of the flora between the GD group and the control group. The abundances of the genera Oribacterium, Mogibacterium, Lactobacillus, Aggregatibacter and Mogibacterium were significantly higher in the GD group than in the control group (P < 0.05).
Conclusions
The intestinal flora of GD patients was significantly different from that of the healthy population. Thus, alteration of intestinal flora may be associated with the development of GD.
Search for other papers by Xingyao Tang in
Google Scholar
PubMed
Search for other papers by Zhi-Hui Song in
Google Scholar
PubMed
Search for other papers by Dawei Wang in
Google Scholar
PubMed
Search for other papers by Jinkui Yang in
Google Scholar
PubMed
Search for other papers by Marly Augusto Cardoso in
Google Scholar
PubMed
Search for other papers by Jian-Bo Zhou in
Google Scholar
PubMed
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Search for other papers by Rafael Simó in
Google Scholar
PubMed
Thyroid hormone, as a modifiable risk factor for dementia, promotes neurocognitive function and regulates metabolic processes. Various studies have defined different thyroid-stimulating hormone cutoffs, but the safest thyroid-stimulating hormone concentration was absent. A dose–response meta-analysis describing the overall functional relation and identifying exposure intervals associated with a higher or lower disease risk is thus desirable. Therefore, our current analysis was conducted to understand the influence of thyroid dysfunction on dementia risk. We searched PubMed, Embase, and Web of Science before May 1, 2020 for human studies published in English. Studies were considered for inclusion if they used a cohort study design to measure the risk of dementia in different thyroid function status groups, diagnosed thyroid functional status and all-cause dementia, included participants aged >18 years, and provided quantitative measures of data. The analysis contained 17 articles with 344,248 individuals with a 7.8-year mean follow-up. Ten studies with 329,287 participants indicated that only subclinical hyperthyroidism was associated with an increased risk of dementia. In contrast, subclinical hypothyroidism, clinical hyperthyroidism, and clinical hypothyroidism did not affect dementia. In the dose–response meta-analysis with 46,417 samples from 11 studies, the association of thyroid-stimulating hormone with the risk of dementia exhibited a U-shaped curve. Our study indicated that subclinical hyperthyroidism was associated with the risk of dementia and the thyroid-stimulating hormone concentration at around 1.55–1.60 mU/L as the optimum range for the risk of dementia.
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Min Yang in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Xiangling Deng in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Shunan Wang in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Bo Zhou in
Google Scholar
PubMed
Search for other papers by Wenquan Niu in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Zhixin Zhang in
Google Scholar
PubMed
Objectives
We aimed to identify and characterize potential factors, both individually and jointly as a nomogram, associated with short stature and pre-shortness in Chinese preschool-aged children.
Methods
Total of 9501 children aged 3–6 years were recruited from 30 kindergartens in Beijing and Tangshan from September to December 2020 using a stratified random sampling method. Effect-size estimates are expressed as odds ratio (OR) and 95% CI.
Results
The prevalence of short stature and pre-shortness in preschool-aged children was 3.9% (n = 375) and 13.1% (n = 1616), respectively. Factors simultaneously associated with the significant risk for short stature, pre-shortness and both included BMI, paternal height, maternal height, birth weight, birth height, latter birth order (≥2) and less parental patience to children. Besides, breastfeeding duration (≥12 months) was exclusively associated with pre-shortness (OR, 95% CI, P: 1.16, 1.01 to 1.33, 0.037), and childhood obesity with both short stature (3.45, 2.62 to 4.54, <0.001) and short stature/pre-shortness (1.37, 1.15 to 1.64, <0.001). Modeling of significant factors in nomograms had descent prediction accuracies, with the C-index being 77.0, 70.1 and 71.2% for short stature, pre-shortness and both, respectively (all P < 0.001).
Conclusions
Our findings indicate the joint contribution of inherited characteristics, nutrition status from the uterus to childhood, and family psychological environment to short stature and pre-shortness in Chinese preschool-aged children. Further validation in other independent groups is warranted.
