Search Results

You are looking at 1 - 1 of 1 items for

  • Author: Antonella Iannaccone x
Clear All Modify Search
Angela Köninger Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany

Search for other papers by Angela Köninger in
Google Scholar
PubMed
Close
,
Antonella Iannaccone Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany

Search for other papers by Antonella Iannaccone in
Google Scholar
PubMed
Close
,
Ensar Hajder Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany

Search for other papers by Ensar Hajder in
Google Scholar
PubMed
Close
,
Mirjam Frank Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University of Duisburg-Essen, Essen, Germany

Search for other papers by Mirjam Frank in
Google Scholar
PubMed
Close
,
Boerge Schmidt Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University of Duisburg-Essen, Essen, Germany

Search for other papers by Boerge Schmidt in
Google Scholar
PubMed
Close
,
Ekkehard Schleussner Department of Obstetrics, Jena University Hospital, Jena, Germany

Search for other papers by Ekkehard Schleussner in
Google Scholar
PubMed
Close
,
Rainer Kimmig Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany

Search for other papers by Rainer Kimmig in
Google Scholar
PubMed
Close
,
Alexandra Gellhaus Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany

Search for other papers by Alexandra Gellhaus in
Google Scholar
PubMed
Close
, and
Hans Dieplinger Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria

Search for other papers by Hans Dieplinger in
Google Scholar
PubMed
Close

Background

Patients suffering from polycystic ovary syndrome (PCOS) are often insulin resistant and at elevated risk for developing gestational diabetes mellitus (GDM). The aim of this study was to explore afamin, which can be determined preconceptionally to indicate patients who will subsequently develop GDM. Serum concentrations of afamin are altered in conditions of oxidative stress like insulin resistance (IR) and correlate with the gold standard of IR determination, the HOMA index.

Methods

Afamin serum concentrations and the HOMA index were analyzed post hoc in 63 PCOS patients with live births. Patients were treated at Essen University Hospital, Germany, between 2009 and 2018. Mann–Whitney U test, T test, Spearman’s correlation, linear regression models and receiver-operating characteristic (ROC) analyses were performed for statistical analysis.

Results

Patients who developed GDM showed significantly higher HOMA and serum afamin values before their pregnancy (P < 0.001, respectively). ROCs for afamin concentrations showed an area under the curve of 0.78 (95% confidence interval (CI) 0.65–0.90) and of 0.77 (95% CI 0.64–0.89) for the HOMA index. An afamin threshold of 88.6 mg/L distinguished between women who will develop GDM and those who will not with a sensitivity of 79.3% and a specificity of 79.4%. A HOMA index of 2.5 showed a sensitivity of 65.5% and a specificity of 88.2%.

Conclusion

The HOMA index and its surrogate parameter afamin are able to identify pre-pregnant PCOS patients who are at risk to develop GDM. Serum afamin concentrations are independent of fasting status and therefore an easily determinable biomarker.

Open access